小剂量吗啡对大鼠活动性的影响

腹腔注射不同剂量吗啡,观察各组大鼠在给药后不同时间的活动性（ｌｏｃｏｍｏｔｏｒａｃｔｉｖｉｔｙ,ＬＡ）,连续给药８天,每天给药后９５ｍｉｎ内,每间隔１５ｍｉｎ,记录大鼠５ｍｉｎ内在限定空间中所走格数。结果表明：随吗啡给药剂量或次数增加,ＬＡ呈升高趋势;使大鼠ＬＡ明显兴夯的适宜低剂量为４ｍｇ／ｋｇ／ｄａｙ,该剂量下每天药后１５－２０ｍｉｎＬＡ为峰值,而且此时段ＬＡ逐日升高,至第８日出现下降趋势,此毕     

相信"过年吃药不吉利"险些丧命

有一些人出于不良的目的,宣称:患病不吃药,烧香念佛好。当然,若是邪教的目的就更险恶了!曾发生过这么一件事情:辽宁省盘锦地区,在民间传出“过年吃药不吉利”的谣言,并称,吃一次药,就一年到头药离不了口,折腾一年,一年在苦海中煎熬。这种显而易见的谣言竟还有人相信,在短短的两天时间内,一家医院就先后抢救了11位心     

Foot Motion Character During Forward and Backward Walking With Shoes and Barefoot

Abstract

Backward walking (BW) has been extensively used in athletic training and orthopedic rehabilitation as it may have value for enhancing balance. This study identified the differences in foot intersegment kinematics (forward walking (FW) vs. time-reversed BW) and plantar pressure parameters of 16 healthy habitually shod individuals walking FW and BW using flexible shoes (SH) and under barefoot conditions (BF). BW was found to have shorter stride length (SL) and higher stride frequency (SF) under BF conditions compared with SH, which indicates a better BW gait stability under BF conditions. Decreased HX/FF dorsiflexion at HO in BW induces less plantar aponeurosis tension which may inhibit the windlass mechanism compared to FW walking. Increased forefoot relative to hindfoot (FF/HF) pronation and sequentially hindfoot relative to tibia (HF/TB) eversion combined with medially distributed plantar pressure and a higher plantar contact area in the medial side in BW–BF maybe beneficial in maintaining balance. These results indicate that BW training may be more reliable under BF conditions compared to the SH conditions based on greater sensory information feedback from the plantar area resulting in better biomechanical behavior.     

How mindfulness affects benign and malicious envy from the perspective of the mindfulness reperceiving model

At present, mindfulness is a hotspot in psychological research. Mindfulness is an effective tool that enables people to effectively inhibit negative emotions. Previous studies have shown that envy is a typical negative emotion; however, envy can be divided into two completely different types: benign envy and malicious envy. The question then arises, how does mindfulness affect both types of envy? Using a mindfulness reperceiving model, we explored the effect of mindfulness on these two different types of envy and on the mediating mechanism of psychological resilience. To accomplish this, we recruited 676 Chinese undergraduates to complete the Mindful Attention Awareness Scale (MAAS), the Benign and Malicious Envy Scale (BEMAS) and the Connor-Davidson Resilience Scale (CD-RISC). The results we obtained showed that mindfulness and psychological resilience significantly and negatively predicted malicious envy and that psychological resilience played a partially mediating role in the relationship. In addition, the results showed that there was no significant effect between mindfulness and benign envy; however, psychological resilience can significantly and positively predict benign envy and played a completely mediating role between mindfulness and benign envy. These results effectively extend theories based on the mindfulness reperceiving model while also being important for promoting benign envy and inhibiting malicious envy in terms of improving mindfulness and psychological resilience.     

科学发明情境中问题提出的脑机制再探

以高生态学效度的科学发明问题情境作为实验材料, 采用静息态功能磁共振成像技术, 基于低频振幅(ALFF)和静息态功能连接(RSFC)的分析方法, 探讨创造性科学问题提出的脑机制。结果发现, 在控制了被试性别、年龄后, 提出新颖有效性问题的比率越高, 左内侧前额叶(Left media prefrontal cortex, L-mPFC)和右小脑前叶(Right cerebellum)的ALFF值越高。进一步功能连接分析发现, 提出新颖有效性问题的比率与mPFC和楔叶(Cuneus)之间的功能连接强度呈显著正相关。结果强调mPFC对于科学发明情境中问题提出的重要作用, 且更高比率的新颖有效性问题的提出是通过mPFC与其它脑区的协同联结来实现的。     

三种常用DIF检测方法的比较研究

本研究在对DIF作出新的更为严格的界定、对三种常用的DIF检澍方法进行详细介绍的基础上．以1999年高考英语试卷75道选择题为研究材料,对三种常用的DIF检测方法进行了实证研究。结果表明：MH方法与SIBTEST方法检测的敏感性较STND方法高;MH方法与SIBTEST方法检出的一致性很高;SIBTEST方法具有较好的性能,在实际应用中可以作为首选的方法;在进行DIF检测时,样本容量在1000左右为宜。     

嗓音源判断过程中的范畴效应和通道效应

该项研究通过设计4种实验条件,旨在探讨不同嗓音词的再认和嗓音判断过程各自的特点及其相互联系。4种实验条件是由2种诵读方式和2种测试方式组合而成,2种诵读方式为同范畴同嗓音和同范畴异嗓音,2种测试方式为视觉呈现和听觉呈现。52名大学生被试随机分成4个独立的组,分别接受一种实验处理。实验结果显示：(1)同范畴同嗓音条件与同范畴异嗓音条件相比,前者项目词的嗓音源判断效果好。提示增加相同记忆源项目间语义联系将有利于记忆源的检测判断。(2)项目再认与项目嗓音判断结果不完全一致,只有在诵读方式为同范畴同嗓音测试方式为听觉呈现情境下,两者有较高的正相关。(3)在同范畴同嗓音诵读条件下,再认反映出学习和测试通道源一致性优势效应,嗓音判断没有反映出通道源一致性优势效应。     

Differential Effect of TEA on Long-Term Synaptic Modification in Hippocampal CA1 and Dentate Gyrus in vitro

The effectiveness of tetraethylammonium (TEA) and high-frequency stimulation (HFS) in inducing long-term synaptic modification is compared in CA1 and dentate gyrus (DG) in vitro. High-frequency stimulation induces long-term potentiation (LTP) at synapses of both perforant path-DG granule cell and Schaffer collateral-CA1 pyramidal cell pathways. By contrast, TEA (25 mM) induces long-term depression in DG while inducing LTP in CA1. The mechanisms underlying the differential effect of TEA in CA1 and DG were investigated. It was observed that T-type voltage-dependent calcium channel (VDCC) blocker, Ni²⁺ (50 μM), partially blocked TEA-induced LTP in CA1. A complete blockade of the TEA-induced LTP occurred when Ni²⁺ was applied together with the NMDA receptor antagonist, D-APV. The L-type VDCC blocker, nifidipine (20 μM), had no effect on CA1 TEA-induced LTP. In DG of the same slice, TEA actually induced long-term depression (LTD) instead of LTP, an effect that was blocked by D-APV. Neither T-type nor L-type VDCC blockade could prevent this LTD. When the calcium concentration in the perfusion medium was increased, TEA induced a weak LTP in DG that was blocked by Ni²⁺. During exposure to TEA, the magnitude of field EPSPs was increased in both CA1 and DG, but the increase was substantially greater in CA1. Tetraethylammonium application also was associated with a large, late EPSP component in CA1 that persisted even after severing the connections between CA3 and CA1. All of the TEA effects in CA1, however, were dramatically reduced by Ni²⁺. The results of this study indicate that TEA indirectly acts via both T-type VDCCs and NMDA receptors in CA1 and, as a consequence, induces LTP. By contrast, TEA indirectly acts via only NMDA receptors in DG and results in LTD. The results raise the possibility of a major synaptic difference in the density and/or distribution of T-type VDCCs and NMDA receptors in CA1 and DG of the rat hippocampus.     

Neuropsychological findings of extrapontine myelinolysis without central pontine myelinolysis

Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are well recognized syndromes related to the rapid correction of hyponatremia, which are reported to show brain stem signs and various movement disorders. Cognitive dysfunction and neuropsychological findings, however, have seldom been reported. Cognitive manifestations in osmotic myelinolysis may have been underestimated due to the prominent brain stem symptoms and movement disorders. We report a case of EPM without CPM and describe the neuropsychological findings of EPM. The absence of CPM in this case made it possible to test neuropsychological function in the acute stage. Neuropsychological testing showed severe impairment of attention, verbal and visual memory, visuospatial function, and frontal/executive function. Language and language-related functions were normal except naming.     

结直肠癌诊断模式的若干思考

结直肠癌是常见的消化道恶性肿瘤,然而在临床上得到诊断时大多已经到了中晚期,错过了最佳的治疗时机。近年来,随着基因相关技术及生物信息技术的迅猛发展,结直肠癌诊断方法得到不断改进,但早期诊断仍不尽如人意。因此现有的诊断模式值得我们去深思,从哲学意义上探索更为完善的诊断模式。