结直肠癌诊断模式的若干思考

结直肠癌是常见的消化道恶性肿瘤,然而在临床上得到诊断时大多已经到了中晚期,错过了最佳的治疗时机。近年来,随着基因相关技术及生物信息技术的迅猛发展,结直肠癌诊断方法得到不断改进,但早期诊断仍不尽如人意。因此现有的诊断模式值得我们去深思,从哲学意义上探索更为完善的诊断模式。     

自编《中小学生非智力因素教师评价量表》的信、效度研究

通过自行编制的《中小学生非智力因素教师评价量表》,以天津市4所中、小学校的4个年级365名学生为被试考察了该量表的质量。研究结果表明：(1)《中小学生非智力因素教师评价量表》具有较高的信度;(2)《中小学生非智力因素教师评价量表》所构想的非智力因素结构模型是完全可以接受的,即有较好的结构效度。     

工作不安全感对员工心理与行为的影响

采用工作不安全感问卷,对不同企业的223名员工进行调查,探讨了工作不安全感中各维度对员工心理与行为的具体影响。结果表明:(1)在工作执行和人际关系不安全感上,男女性别差异显著;在工作丧失、人际关系不安全感、群体组织公民行为以及留职意愿这四个维度上,不同企业类型差异显著。(2)工作丧失、工作执行,人际关系不安全感均对留职意愿有正向预测作用;过度竞争不安全感对群体组织公民行为及个体组织公民行为均有显著的负向预测作用。     

Differential Effect of TEA on Long-Term Synaptic Modification in Hippocampal CA1 and Dentate Gyrus in vitro

The effectiveness of tetraethylammonium (TEA) and high-frequency stimulation (HFS) in inducing long-term synaptic modification is compared in CA1 and dentate gyrus (DG) in vitro. High-frequency stimulation induces long-term potentiation (LTP) at synapses of both perforant path-DG granule cell and Schaffer collateral-CA1 pyramidal cell pathways. By contrast, TEA (25 mM) induces long-term depression in DG while inducing LTP in CA1. The mechanisms underlying the differential effect of TEA in CA1 and DG were investigated. It was observed that T-type voltage-dependent calcium channel (VDCC) blocker, Ni²⁺ (50 μM), partially blocked TEA-induced LTP in CA1. A complete blockade of the TEA-induced LTP occurred when Ni²⁺ was applied together with the NMDA receptor antagonist, D-APV. The L-type VDCC blocker, nifidipine (20 μM), had no effect on CA1 TEA-induced LTP. In DG of the same slice, TEA actually induced long-term depression (LTD) instead of LTP, an effect that was blocked by D-APV. Neither T-type nor L-type VDCC blockade could prevent this LTD. When the calcium concentration in the perfusion medium was increased, TEA induced a weak LTP in DG that was blocked by Ni²⁺. During exposure to TEA, the magnitude of field EPSPs was increased in both CA1 and DG, but the increase was substantially greater in CA1. Tetraethylammonium application also was associated with a large, late EPSP component in CA1 that persisted even after severing the connections between CA3 and CA1. All of the TEA effects in CA1, however, were dramatically reduced by Ni²⁺. The results of this study indicate that TEA indirectly acts via both T-type VDCCs and NMDA receptors in CA1 and, as a consequence, induces LTP. By contrast, TEA indirectly acts via only NMDA receptors in DG and results in LTD. The results raise the possibility of a major synaptic difference in the density and/or distribution of T-type VDCCs and NMDA receptors in CA1 and DG of the rat hippocampus.     

Neuropsychological findings of extrapontine myelinolysis without central pontine myelinolysis

Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are well recognized syndromes related to the rapid correction of hyponatremia, which are reported to show brain stem signs and various movement disorders. Cognitive dysfunction and neuropsychological findings, however, have seldom been reported. Cognitive manifestations in osmotic myelinolysis may have been underestimated due to the prominent brain stem symptoms and movement disorders. We report a case of EPM without CPM and describe the neuropsychological findings of EPM. The absence of CPM in this case made it possible to test neuropsychological function in the acute stage. Neuropsychological testing showed severe impairment of attention, verbal and visual memory, visuospatial function, and frontal/executive function. Language and language-related functions were normal except naming.     

经济法试题DIF的参数法检测研究

该研究基于项目反应理论的Samejima等级反应模型(GRM),在MULTILOG软件支持下,应用参数检测方法,对某年度全国性资格考试的某科目试卷中经济法部分的21个项目做了DIF检测分析。结果如下:存在性别DIF的项目一个,存在民族DIF的项目四个,存在工作性质DIF的项目一个。其中项目68在民族层面上表现为一致性DIF,项目64既存在民族DIF又存在工作性质DIF。通过对项目统计量、反应曲线的分析和专家的讨论,文章最后还分析了产生这些DIF的几个可能的原因。     

在国际道德经论坛闭幕式上的致辞

女士们,先生们: 今天,我有幸参加国际道德经论坛闭幕典礼这样一个盛事,感到非常高兴.我对论坛的圆满成功表示热烈祝贺! 崇尚和谐、爱好和平,是中华民族高尚的精神品格.在春秋战国时期,中华民族的先哲们就确立起"和为贵"、"和而不同"、"重生贵和"的价值理念.     

哪种基督教?哪类基督徒?——试析现代基督教内部的阵营分组与分野

基督教内部的阵营分组,以往主要是以传统宗派来作为自我身份界定与归属的界限,在20世纪则转换为主要以神学立场为依据的跨宗派性的阵营分组模式,并进而演化成自由派与保守派这两大阵营。也就是说当今的基督教世界并非是铁板一块的现实,而是分化成许多新的团体、运动和趋势,它们又进一步分组和集结成两大相互对峙和对立的阵营。本文对基督教内部阵营分化与分组的起因、派系、脉络、分野与冲突做出了梳理、剖析和评判。     

Validation of a Chinese Version of the Obsessive Beliefs Questionnaire

Cognitive models of obsessive-compulsive disorder (OCD) assign a central role to maladaptive beliefs. Evaluation of these OCD beliefs in Western countries is commonly accomplished using the Obsessive Beliefs Questionnaire (OBQ) and is important for conceptualizing and treating OCD. It remains unclear if Western models of OCD beliefs are appropriate for sufferers in some non-Western regions, such as China, which represents nearly 20 % of the world population. Thus, the aim of present study is to examine the psychometric properties of a Chinese translation of the OBQ in three samples: 1,322 undergraduates, 139 patients with OCD, and 79 patients with other anxiety disorders. Confirmatory factor analysis revealed poor fit for multiple English-based models of the OBQ. However, an exploratory factor analysis supported an OBQ model that differs slightly from the English version: (1) Perfectionism/Certainty (P/C), (2) Over-Estimation of Threat (T), (3) Importance of Thoughts/Responsibility for Harm (I/R). This Chinese version of the OBQ (C-OBQ) contains 30 items and shows adequate internal consistency, test-retest reliability, construct validity, and criterion-related validity. In China, the C-OBQ may be a useful instrument for delineating cognitive patterns associated with OCD to inform research and treatment.