Genetic Testing and Parkinson Disease: Assessment of Patient Knowledge,Attitudes, and Interest

The most common genetic contributor to late-onset Parkinson disease (PD) is the LRRK2 gene. In order to effectively integrate LRRK2 genetic testing into clinical practice, a strategy tailored to the PD population must be developed. We assessed 168 individuals with PD for baseline knowledge of genetics, perceived risk, and interest and opinions regarding genetic counseling and testing. Most participants felt that they were familiar with general genetics terms but overall knowledge levels were low, with an average score of 55%. The majority of participants thought it was likely they inherited a PD gene (72%), believed genetic testing for PD would be useful (86%), and were interested in genetic testing (59%) and genetic counseling (56%). However, only a few participants had heard of any genetic tests for PD (29%) or LRRK2 (10%). There appears to be a significant level of interest in genetics and genetic testing within the PD population, but a considerable deficit in genetics knowledge and an over-estimation of risk. Genetic education and counseling tools to address these needs were developed to provide patients with the ability to make informed and knowledgeable genetic testing decisions.     

The auditory motion aftereffect: its tuning and specificity in the spatial and frequency domains

In this paper, the auditory motion aftereffect (aMAE) was studied, using real moving sound as both the adapting and the test stimulus. The sound was generated by a loudspeaker mounted on a robot arm that was able to move quietly in three-dimensional space. A total of 7 subjects with normal hearing were tested in three experiments. The results from Experiment 1 showed a robust and reliable negative aMAE in all the subjects. After listening to a sound source moving repeatedly to the right, a stationary sound source was perceived to move to the left. The magnitude of the aMAE tended to increase with adapting velocity up to the highest velocity tested (20 degrees/sec). The aftereffect was largest when the adapting and the test stimuli had similar spatial location and frequency content. Offsetting the locations of the adapting and the test stimuli by 20 degrees reduced the size of the effect by about 50%. A similar decline occurred when the frequency of the adapting and the test stimuli differed by one octave. Our results suggest that the human auditory system possesses specialized mechanisms for detecting auditory motion in the spatial domain.     

A cGMP-dependent protein kinase gene, foraging, modifies habituation-like response decrement of the giant fiber escape circuit in Drosophila

The Drosophila giant fiber jump-and-flight escape response is a model for genetic analysis of both the physiology and the plasticity of a sensorimotor behavioral pathway. We previously established the electrically induced giant fiber response in intact tethered flies as a model for habituation, a form of nonassociative learning. Here, we show that the rate of stimulus-dependent response decrement of this neural pathway in a habituation protocol is correlated with PKG (cGMP-Dependent Protein Kinase) activity and foraging behavior. We assayed response decrement for natural and mutant rover and sitter alleles of the foraging (for) gene that encodes a Drosophila PKG. Rover larvae and adults, which have higher PKG activities, travel significantly farther while foraging than sitters with lower PKG activities. Response decrement was most rapid in genotypes previously shown to have low PKG activities and sitter-like foraging behavior. We also found differences in spontaneous recovery (the reversal of response decrement during a rest from stimulation) and a dishabituation-like phenomenon (the reversal of response decrement evoked by a novel stimulus). This electrophysiological study in an intact animal preparation provides one of the first direct demonstrations that PKG can affect plasticity in a simple learning paradigm. It increases our understanding of the complex interplay of factors that can modulate the sensitivity of the giant fiber escape response, and it defines a new adult-stage phenotype of the foraging locus. Finally, these results show that behaviorally relevant neural plasticity in an identified circuit can be influenced by a single-locus genetic polymorphism existing in a natural population of Drosophila.     

欧阳渐"佛法非宗教非哲学"思想衍论

“佛法非宗教非哲学”的思想是近代佛学大师欧阳渐先生提出来的。该文考察了欧阳渐对“佛法”的理解,并在对“如何正确理解”、“如何客观评判”、“如何合理发扬”欧阳渐“佛法”思想等问题展开讨论的同时,简要分析了该思想的成因、价值及其学术意义。该文认为：要客观评判欧阳渐的“佛法”思想,应该正确区分“佛法”与“佛教”、“佛学”的关系,全面理解其“佛法”思想,并根据“佛法”的实际来加以评价;佛法非宗教非哲学而始终为人类所必需,乃是欧阳渐“佛法”思想留给我们的有益启示,值得在深入思考和研究的基础上加以发扬。     

Cross-cultural equivalence and validity of the Vietnamese MMPI-2: assessing psychological adjustment of Vietnamese refugees

The cross-cultural equivalence and validity of the Vietnamese translation of the Minnesota Multiphasic Personality Inventory--2 (MMPI-2) were examined in a sample of 1st-generation Vietnamese refugees in the United States (N = 143). Respondents completed the Vietnamese MMPI-2, the Harvard Trauma Questionnaire, a measure of acculturation, and a demographic questionnaire. An inspection of MMPI-2 mean profiles and items showing extreme endorsement rates suggested that certain symptom tendencies and cultural values may be reflected in responses to some MMPI-2 items. Older age, lower acculturation, greater experienced premigration-postmigration traumas, and military veteran status were all associated with elevated MMPI-2 profiles, suggesting that the MMPI-2 functions in a reasonably equivalent and valid way in this population.     

关于异种器官移植的问题

随着器官移植的广泛开展,器官短缺的问题日渐突出,８０年代末起异种器官移植的应用引起人们的重视,并形成热潮。但研究表明,克服异种移植排斥非易事,异种器官移植可能引起的病毒性疾病的传播,以及异种器官分子不相容性造成的种属屏障,都使异种器官移植的前景难料。     

信度估计的γ系数

本文提出了信度估计的γ系数。与今天应用最广泛的α系数相比,γ系数较少受到被试样本特点的影响,更多地反映了测验受到误差因素影响的程度,因此,γ系数是更好的测验信度估计指标。     

一般社会情境中风险认知的实验研究

风险认知是一个新的研究领域,随着经济的发展应愈来愈受到重视。本研究在一般社会情境下,讨论了对46个风险因素的风险程度及风险特征的知觉;个性特征与风险认知的关系;群体的风险认知类型特征,以及各样本间的比较分析。研究结论提供了公众风险认知结构的初步轮廓。     

The effect of the physical versus mental presence of a high-powered person on consumers' healthy food choices

Consumers make distinct food choices when they see versus when they think about a powerful person. This research identifies two scenarios involving the presence of a high-powered other, physical presence versus mental presence, and examines the effect of the physical and mental presence of a high-powered other on consumers' healthy food choices. Conducting six experiments, we show that the physical presence of a high-powered other increases one's self-enhancement motivation and leads to healthier food choices, while the mental presence of a high-powered other increases one's perceived constraints and leads to unhealthy food choices. We also find that interpersonal closeness moderates the positive effect of the physical presence of a high-powered other on healthy food choices but does not moderate the negative effect of the mental presence of a high-powered other on healthy food choices.     

概念及概念结构研究新进展

近来有关归类和概念结构的研究与理论出现了两个方面的转变。第一个方面是从概念定义属性的假设 (经典观 )到概念表征属性的观点 (概率观 ) ;第二个方面是从概念以相似性组织的观点到概念围绕理论而组织的观点。本文综合概述了基于相似性和理论驱动的归类理论。