糖皮质激素治疗脓毒血症的策略

脓毒症是由感染所致的破坏性的全身炎症反应综合征,进一步发展可导致多器官功能障碍综合征,甚至休克,成为危重患者最主要的死亡原因之一。糖皮质激素是脓毒症的重要辅助药物,其治疗机制在于其抑制机体的炎症反应,但其使用剂量、疗程、时间一直存在争议。本文通过回顾糖皮质激素在治疗脓毒症的发展历程,深入探讨糖皮质激素治疗脓毒血症的治疗策略。     

Influences of vowel and tone variation on emergent word knowledge: a cross‐linguistic investigation

To learn words, infants must be sensitive to native phonological contrast. While lexical tone predominates as a source of phonemic contrast in human languages, there has been little investigation of the influences of lexical tone on word learning. The present study investigates infants’ sensitivity to tone mispronunciations in two groups of infants. For one group (Chinese learners), tone is phonemic in their native language, and for the second group (English learners), tone is non‐phonemic and constituted suprasegmental variation. In Experiment 1, English learners were trained on novel word–object pairings and tested on their recognition of correct pronunciations, tone and vowel mispronunciations of these words at 18 and 24 months. In Experiment 2a, bilingual English‐Chinese learners were tested on a similar task translated into Chinese at the same age intervals. Results demonstrate that non‐tonal learners treated tonal and vowel substitutions alike as mispronunciations at 18 months but only treated vowel substitutions as mispronunciations at 24 months. Tonal learners treated both tonal and vowel substitutions as mispronunciations at both ages. In Experiment 2b, bilingual non‐tone language learners were tested on the same set of tasks replicating a similar set of results as monolingual non‐tone language learners (Experiment 1). Findings point to an early predisposition to treat tone as a defining characteristic of words regardless of its lexical relevance at 18 months. Between 18 and 24 months, learners appear to ascribe lexical relevance to tone in a language‐specific manner. The current study identifies the influences of tone variation on memories for newly learned words and the time period during which lexical tone – a highly frequent constituent of human languages – actually becomes lexical for early learners. Findings are contextualized with prevailing models of the developing lexicon.     

Maternal supplementation of nucleotides improves the behavioral development of prenatal ethanol-exposed mice

Maternal ethanol consumption during pregnancy can induce learning deficits in the offspring. The objective of this study was to assess whether supplementation of exogenous nucleotides during pregnancy and lactation would ameliorate prenatal ethanol-induced learning and memory deficits in the offspring of mice, and to explore the possible mechanisms. In the present study, pregnant C57BL/6J mice were exposed to ethanol (5 g/kg body weight) intragastrically from gestational day (GD) 6 to GD15. The dams in exogenous nucleotide intervention groups were fed with feed containing 0.01 %, 0.04 %, or 0.16 % nucleotide powder, with control and ethanol groups receiving normal feed. The dams were allowed to deliver naturally and to breast feed their offspring. After weaning, behavioral tests were carried out in the offspring of each group. Serum oxidation indexes were analyzed, and the hippocampus of each offspring was collected and detected for acetyl cholinesterase (AChE) activity and the expression of p-CREB, CREB, and BDNF. The results showed that maternal supplementation with exogenous nucleotides during pregnancy could ameliorate prenatal ethanol-induced learning and memory deficits in the offspring of mice, through improving their antioxidant capacity, reversing hippocampus AChE levels, and allowing the expression of some proteins related to learning and memory. However, different sensitivities were found between the two sexes.     

邻近效应对多媒体学习中图文整合的影响:线索的作用

在多媒体学习中图文排列的邻近或远离会影响学习的效果。本研究操纵了多媒体呈现的图文排列位置,采用颜色作为线索引导注意,探讨了线索有无和图片-文字的空间位置对多媒体学习图文整合的影响。结果发现:图文邻近呈现时的保持测验和迁移测验成绩好于图文远离呈现,图文邻近呈现时学习者对关键兴趣区的进出次数更多,体现出以文字为导向的阅读模式。线索并没有单独影响学习成绩和注意分配;但结合图文位置后,发现有线索时图文邻近学习材料的注视次数、进出关键兴趣区的次数显著多于图文远离。研究认为:图文的邻近效应不仅提高学习者对知识的识记和理解,同时也影响了学习者的注意分配过程,图文邻近呈现有助于图片和文本信息的注意联结和知识整合;线索能使邻近效应得到凸显,更好地促进图文信息的注视加工,但没有改进学习的效果。     

Momentary Return of the Cosmic Unconscious: The Nature of Zen/Chan Enlightenment

Zen/Chan, which used to be a Far Eastern philosophy-cum-religion, has evolved into a global cultural phenomenon. Despite the many views expressed by numerous thinkers in the world, the consensus on Chan and Chan enlightenment remains an agnostic Oriental mysticism. By exploring Chan and enlightenment from a combined perspective of history, philosophy, psychology, religion and linguistics, this article proposes a hitherto unexpressed view. Chan enlightenment is a prenatal physico-psychological existence, which grows out of a fetal subject’s perception of the womb. Although this primordial mode of perception is unconscious, it is cosmic in nature because for the fetal subject the womb is the whole world with which it feels to be at one. This unconscious oneness may be termed the ‘cosmic unconscious’. Once born, no one can return to the prenatal mental state, but through personal cultivation and Chan practice one can experience a fleeting moment of the cosmic unconscious. In the final analysis, the essence of Chan enlightenment is a momentary return of the cosmic unconscious. It is, therefore, not a great wisdom which enables one to have a profound understanding of the self and the world, but a non-wisdom induced by a return to the prenatal primal being of life.     

Chinese University Students’ Perceptions of Plagiarism

This study examines Chinese undergraduates’ perceptions of plagiarism in English academic writing in relation to their disciplinary background (i.e., hard vs. soft disciplines), academic enculturation (i.e., length of study in university), and gender. Drawing on data collected from 270 students at two universities in China, it finds clear discipline-based differences in participants’ knowledge of plagiarism and perceptions about its causes; an enculturational effect on perceived acceptability of and condemnatory attitudes toward plagiarism, with senior students being less harsh than their junior counterparts; and complex interactions among disciplinary background, length of study, and gender. Furthermore, it reveals conceptions of (il)legitimate intertextuality (i.e., textual borrowing) differing from those prevalent in Anglo American academia and clearly punitive stances on perceived plagiarism. These results suggest the need to take an educative rather than punitive approach to source use in English academic writing.     

熟练潮-普双言者的语义通达机制:来自通道比较的证据

采用跨语言启动的范畴判断范式,通过2个实验,考察了熟练潮-普双言者在听觉通道内和听-视跨通道条件下的语义通达机制。结果发现,无论是以潮州话词语为启动词,还是以普通话词语为启动词,当词对具有高语义相关时,启动词均对目标词产生了显著的跨语言启动效应;在听觉通道内,两种语言之间的启动量无差异,而在听-视跨通道条件下,L2对L1的启动量显著大于L1对L2的启动量。这些结果表明,熟练潮-普双言者共享语义(概念)表征,词汇表征既相互独立又互相联系,L1与L2的词汇均能直接通达语义表征,但其联系强度及其相互之间的词汇表征联系强度均存在通道差异性。整个研究结果支持Kroll等人的修正分级模型。     

Judgment of infant cry: The roles of acoustic characteristics and sociodemographic characteristics

Adult judgments of infant cry are determined by both acoustic properties of the cry and listener sociodemographic characteristics. The main purpose of this research was to investigate how these two sources shape adult judgments of infant cry. We systematically manipulated both the acoustic properties of infant cries and contrasted listener sociodemographic characteristics. Then, we asked participants to listen to several acoustic manipulations of infant cries and to judge the level of distress the infant was expressing and the level of distress participants felt when listening. Finally, as a contrasting condition, participants estimated the age of the crying infant. Using tree‐based models, we found that judgments of the level of distress the infant was expressing as well as the level of distress listeners felt are mainly accounted for by select acoustic properties of infant cry (proportion of sound/pause, fundamental frequency, and number of utterances), whereas age estimates of a crying infant are determined mainly by listener sociodemographic characteristics (gender and parental status). Implications for understanding infant cry and its effects as well as early caregiver‐infant interactions are discussed.