Target Groups for Preventing AIDS Among Intravenous Drug Users

The acquired immune deficiency syndrome (AIDS) has rapidly become the most serious medical consequence of injecting illicit drugs. Its potential impact on intravenous (IV) drug use is enormous. Human immunodeficiency virus (HIV, also known as HTLV-III and LAV), the virus that causes AIDS, appears, usually, to lead to lifelong infection. At present there is no effective treatment, and the treatments under development may require lifelong antiviral therapy. Since most of the antibody produced in response to HIV infection does not neutralize the virus, and since there is substantial genetic variation in the virus, it will be difficult to develop a vaccine. Even after vaccines are developed, testing their safety and efficacy will be formidable problems. Until either effective treatment or vaccines are developed, control of the epidemic among IV drug users must be attempted through behavior change/prevention efforts. In this paper we will review the epidemiology of AIDS among IV drug users and characteristics of the IV drug-use subculture relevant to prevention efforts. We will then identify different target groups for these prevention efforts, present available evidence about behavior change in these groups, and then briefly discuss how to prevent transmission of HIV to heterosexual partners who are not themselves IV drug users and to the children of IV drug users.     

Accessibility of case and gender contrasts for agent--object assignment in Broca's aphasics and fluent anomics

Yugoslav agrammatic Broca's aphasics, fluent anomics, and control subjects were tested for comprehension of agent-object relations in a series of simple Serbo-Croatian sentences in the conversational past tense, consisting of two nouns and a transitive action verb. The availability of two closed class cues--case contrasts and gender contrasts--as well as the availability of an open class lexical cue--animacy contrasts--was varied across sentences. An analysis of subjects' agent-object assignments yielded the following results: Both Broca's aphasics and fluent anomics showed a selective impairment in sensitivity to closed class morphology, although anomics were considerably less impaired than Broca's aphasics. This finding was interpreted as evidence for a non-syndrome-dependent vulnerability of abilities to process closed class morphology for comprehension. In addition, the pattern of agent-object assignments for Broca's aphasics revealed that the degree to which they were able to access the two closed class cues depended on a convergence of the various cues to agent-object relations. In particular, a convergence of case and gender contrasts had an interactive effect on Broca's responses: Gender agreement cues were accessed only in the presence of convergent case contrasts. Conversely, sensitivity to case contrasts was dramatically heightened in the presence of convergent gender contrasts. These results were consistent with a view that the two cues function as intrasentential "primes" or "retrieval cues" for one another.     

Cognitive impairment in preschoolers: Identification using the personality inventory for children-revised

This study evaluated the clinical validity of the Intellectual Screening, Development, and Achievement scales of the Personality Inventory for Children-Revised (PIC-R), as well as the newly derived PIC-R Factor IV scale, in identifying cognitive impairment in a clinic-referred sample of preschoolers. The clinical validity of these PIC-R subscales was also compared to that of the Minnesota Child Development Inventory (MCDI). The results showed that the PIC-R scales and Factor IV were reasonably successful in identifying cognitively impaired preschoolers, but much less successful in identifying cognitively normal preschoolers. Overall, the MCDI was the most successful in correctly identifying the preschoolers' cognitive status.     

The relationship of affiliative arousal to dopamine release

Higher levels of affiliation motivation after exposure to affiliative films are significantly related to higher dopamine concentrations in saliva in one study of 61 college students of both sexes, and in plasma in another study of 47 adults of both sexes. Individuals high in dispositionaln Affiliation, if they also reported high life stress, showed high gains in dopamine concentration in plasma after exposure to an affiliative film significantly more often than other individuals. Since aroused affiliation motivation was not associated with higher concentrations of norepinephrine, epinephrine, or cortisol in either study, it appears likely that dopamine is especially associated with arousal of affiliation motivation, just as norepinephrine has been found to be associated with arousal of power motivation. Thus, different motives may be subserved by different hormones, making it unlikely that all motives lead to the same state of physiological arousal.This research was carried out when all the authors were connected with the Department of Psychology and Social Relations at Harvard University. We acknowledge with thanks the support of the John D. and Catherine T. MacArthur Foundation through a grant to the senior author.     

Perceived control and health

Perceived control (PC) is defined as thebelief that one can determine one’s own internal states and behavior, influence one’s environment, and/or bring about desired outcomes. Two important dimensions of PC are delineated: (1) whether the object of control is located in the past or the future and (2) whether the object of control is over outcome, behavior, or process. A variety of constructs and measures of PC (e.g., efficacy, attribution, and locus of control) are discussed in relation to these dimensions and selected studies are reviewed. The issues, controversies, and limits of the research on perceived control and health are addressed in terms of the antecedents and consequences of perceived control. Investigations should clearly conceptualize the object of perceived control, use measures that match the conceptualization, and when attempting to manipulate control, directly measure perceived control. The relation between PC and health outcomes is complex, and different aspects of PC may interact to affect health outcomes.     

The role of phonemes and syllables in the perceived similarity of speech sounds for children

In two experiments, we investigated the factors that influence the perceived similarity of speech sounds at two developmental levels. Kindergartners and second graders were asked to classify nonsense words, which were related by syllable and phoneme correspondences. The results support the existence of a developmental trend toward increased attention to individual phonemic segments. Moreover, one significant factor in determining the perceived similarity of speech sounds appears to be the position of the component correspondences; attention to the beginning of utterances may have developmental priority. An unexpected finding was that the linguistic status of the unit involved in a correspondence (whether it was a syllable or a phoneme) did not seem particularly important. Apparently, the factors which contribute to the perceived similarity of speech sounds in the classification task are not identical to those which underlie performance in explicit segmentation and manipulation tasks, since in the latter sort of task, syllables are more accessible than phonemes for young children. The present task may tap a level of processing that is closer to the one entailed in word recognition and lexical access.     

The facial muscle patterning of posed and imagery-induced expressions of emotion by expressive and nonexpressive posers

Much research on emotional facial expression employs posed expressions and expressive subjects. To test the generalizability of this research to more spontaneous expressions of both expressive and nonexpressive posers, subjects engaged in happy, sad, angry, and neutral imagery, and voluntarily posed happy, sad, and angry facial expressions while facial muscle activity (brow, cheek, and mouth regions) and autonomic activity (skin resistance and heart period) were recorded. Subjects were classified as expressive or nonexpressive on the basis of the intensity of their posed expressions. The posed and imagery-induced expressions were similar, but not identical. Brow activity present in the imagery-induced sad expressions was weak or absent in the posed ones. Both nonexpressive and expressive subjects demonstrated similar heart rate acceleration during emotional imagery and demonstrated similar posed and imagery-induced happy expressions, but nonexpressive subjects showed little facial activity during both their posed and imagery-induced sad and angry expressions. The implications of these findings are discussed.