Nosology and Causal Necessity; The Relation BetweenDefining a Disease and Discovering its Necessary Cause

The problem of disease definition is related to theproblem of proving that a certain agent is thenecessary cause of a certain disease. Natural kindterms like rheumatoid arthritis and AIDS refer toessences which are discoverable rather thanpredeterminate. No statement about such diseases isa priori necessarily true. Because theories onnecessary causes involve natural kind semantics,Koch's postulates cannot be used to falsify or verifysuch theories. Instead of proving that agent A is thenecessary cause of disease D, we include A in atheoretical definition of D, take this to representthe real meaning of D, and discard thepretheoretical definition. This is illustrated byKoch's own attempt to prove he had discovered thenecessary cause of tuberculosis. Methodologicalarguments about disease causation require a clear viewof our use of diagnostic terms. Medical lexicographersshould do more to provide such a view.     

The effect of lightness contrast on the colored Müller-Lyer illusion

Two subjects estimated the length of the central line in red-and blue Müller-Lyer figures that were viewed both foveally and parafoveally. The illusion figures were defined by either lightness and hue differences between figure and ground or by a hue difference alone. For both subjects, the figures defined solely by hue produced larger illusions. Since depth-cue scaling and other cognitive factors did not cause the enlargement, it was concluded that the robust, hue-produced illusions resulted from contour interactions generated within parvocellular channels that are specialized for coding color.     

Naming versus matching in color constancy

In this paper, a replication of the color-constancy study of Arend and Reeves (1986) is reported, and an alternative method is presented that can be used for the study of higher order aspects of color constancy, such as memory, familiarity, and perceptual organization. Besides a simultaneous presentation of standard and test illuminants, we also carried out an experiment in which the illuminants were presented successively. The results were similar to Arend and Reeves’s; however, in the object-matching condition of the successive experiment, we found an overestimation, instead of an underestimation, of the illuminant component. Because the results of matching experiments are difficult to interpret, mainly due to their sensitivity to instruction effects, we introduced another type of color-constancy task. In this task, subjects simply named the color of a simulated patch. It was found that, by applying such a task, a reliable measure of the degree of identification of object color can be obtained.     

An Implicit Theory of Intelligence-Related Mental Activities

ABSTRACT Mental act verbs are used to study implicit theories of intelligence as represented by mental activities. First, the multidimensional structure of the verbs was studied using a sorting task. The resulting structure was interpreted primarily in terms of three properties: a working property that refers to the operational aspect of information processing (and that is closely related to depth of a cognitive activity), a judgment property, and a creativity property. Second, the notion of intelligence was projected onto the structure, rating the verbs to determine how much intelligence they represented. We discovered that mental activities scoring high on intelligence were related primarily to the working property and to in-depth processing.     

Gamma-L-glutamyl-L-aspartate, interacting with NMDA receptors, affects appetitive visual discrimination tasks in mice.

gamma-L-glutamyl-L-aspartate (gamma-LGLA), which interacts with NMDA receptors, has been shown to impair retention of an active avoidance task in mice. Here, we specified the behavioral effects of gamma-LGLA on acquisition and retention of appetitive nondelayed visual discrimination tasks. Three experiments were conducted: the peptide (0.25 and 2.5 microM/kg/25 ml. ip) was administered 3 min after each of the first six sessions of either original learning, reversal 1 or reversal 3. gamma-LGLA affected acquisition of the original task and of the first reversal, as revealed by an absence of improvement on initial sessions and an increased number of sessions to reach criterion fixed at 7 of 10 correct choices on three consecutive sessions. This deficit did not result from an action of the peptide on position habits (repetition of spatial choices) nor on motivational processes, suggesting a specific interference of gamma-LGLA with acquisition and memorization of the visual rule. In contrast, gamma-LGLA had no effect on acquisition of the third reversal, in which the positively reinforced visual stimulus was identical to that used on the first reversal. These results show that the behavioral deficits of gamma-LGLA, which had previously been demonstrated in an aversive task, can be generalized to appetitive tasks based on acquisition of a new rule.     

Effect of changes in fin-length on apparent shaft-length and depth in the Müller-Lyer illusion.

Müller-Lyer figures with outgoing fins were back illuminated and apparent shaft-length and depth were both judged by 20 undergraduates. With the angle between the fins constant, progressive increases in fin-length produced first an increase in the apparent shaft-length and then a decrease. Changes in fin-length, however, had no significant effect on apparent depth. These data were interpreted as inconsistent with an account of the Müller-Lyer illusion in terms of perspective theory, since the latter predicts systematic changes in perceived shaft-length to be associated with systematic changes in perceived depth.