Genetics of human episodic memory: dealing with complexity

Episodic memory is a polygenic behavioral trait with substantial heritability estimates. Despite its complexity, recent empirical evidence supports the notion that behavioral genetic studies of episodic memory might successfully identify trait-associated molecules and pathways. The development of high-throughput genotyping methods, of elaborated statistical analyses and of phenotypic assessment methods at the neural systems level will facilitate the reliable identification of novel memory-related genes. Importantly, a necessary crosstalk between behavioral genetic studies and investigation of causality by molecular genetic studies will ultimately pave the way towards the identification of biologically important, and hopefully druggable, genes and molecular pathways related to human episodic memory.     

Looking from the Outside/In: Re-thinking Research Ethics Review

This paper shares my reflections on the research ethics review process, from the point of view of both a qualitative researcher and a member of an institutional research ethics review board. By considering research ethics review, first as practice, then as policy, as a relationship and, finally, as a performance, I attempt to outline a new vision of research ethics, one that engages seriously with the relationship between receiving ethics approval, and conducting ethical research.     

Refining the dual-stage account of intertrial feature priming: Does motor response or response feature matter?

Numerous studies have shown that repetition of search-relevant attributes facilitates visual search performance. For example, Maljkovic and Nakayama (1994) showed that when observers search for a target defined by its color and report its shape, repetition of the target color speeds search, an effect known as priming of pop-out. While intertrial feature priming in search was initially thought to affect perceptual processes, the idea that it also affects postselection stages of processing is increasingly acknowledged. However, because in previous studies repetition of the motor response has typically been confounded with repetition of the response feature, it is not clear what mechanisms underlie the postselection effect of intertrial priming. In the present study, we dissociated the two repetition types. The results showed that repetition of the target-defining attribute from the previous trial affects selection of the motor response but not discrimination of the response attribute. The implications for current accounts of intertrial priming are discussed.     

Emotional context influences access of visual stimuli to anxious individuals' awareness

Anxiety has been associated with enhanced unconscious processing of threat and attentional biases towards threat. Here, we focused on the phenomenology of perception in anxiety and examined whether threat-related material more readily enters anxious than non-anxious individuals' awareness. In six experiments, we compared the stimulus exposures required for each anxiety group to become objectively or subjectively aware of masked facial stimuli varying in emotional expression. Crucially, target emotion was task irrelevant. We found that high trait-anxiety individuals required less sensory evidence (shorter stimulus exposure times) to become aware of the face targets. This anxiety-based difference was observed for fearful faces in all experiments, but with non-threat faces, it emerged only when these were presented among threatening faces. Our findings suggest a prominent role for affective context in high-anxiety individuals' conscious perception of visual stimuli. Possible mechanisms underlying the influence of context in lowering awareness thresholds in anxious individuals are discussed.     

Focusing in statement interpretation

The present study reports on the processing strategies used by young children (7 and 9) in a task of statement interpretation. The statements were composed of two assertions, presented either in parataxis (Peter sees, he has a marble) or in a modal structure (Peter sees that he has a marble); variations on the form of the verb (affirmative or negative) and on the subjects of the two predicates (same subject or different subjects) were also taken into account. Through the study of the processing order of the two assertions, the purpose was to bring out the phenomena of semantic focusing on one or the other piece of information. The task used was a construction task: The child had to enact the statements with the help of various elements corresponding to the different assertions. Main results showed that, when the information was presented in parataxis, it was generally processed in the enunciation order. On the other hand, in the modal form the focusing was clear: It bore on the dictum (to have a marble) in the affirmative form, and on the modal verb (Peter does not see...) when it was negative. The interpretation of the various focusing processes are discussed.     

La fonction argumentative des marques de la langue

The present paper reports a set of experimental studies concerning the comprehension of French argumentative operators and connectives. The first part is a presentation of the theoretical framework, the methodological problems and some of the most general results. Experiments were carried out in the perspective of the linguistic theory of argumentation developed by Anscombre and Ducrot. According to this theory, a number of devices in language are mainly defined by their argumentation function, i.e. by the types of discursive sequences and conclusions they involve. Three categories of such devices were examined: (1) operators like “presque” (almost), “à peine” (hardly), “au moins” (at least), etc. which give an argumentative orientation to the statement; (2) co-orientation connectives, like “même” (even), which relate two statements oriented towards the same conclusion; (3) counter-orientation connectives, like the concessive ones (“mais” (but), “quand même” (even so), etc.), which relate two statements oriented towards opposite conclusions. The data shed light on issues such as: What is the nature of the relationship between the informative and argumentative functions of different operators? Is there a hierarchical relation between the argumentative processes of “co-orientation” and “counter-orientation”? What is the role of negation in the processing of argumentative sequences? The second part of the paper focuses specifically on the study of how 8 and 10 year-old children process “counter-oriented” statements. Five concessive connectives were studied: “mais”, “pourtant”, “quand même”, “même si”, “bien que”. The test was composed of two successive completion tasks: in one task the children had to choose the relevant context of complex sentences involving concessive connectives; in the other task they had to choose their relevant conclusion. Main results show a clear evolution in the performance of children between 8 and 10, suggesting that concessive strategies are not completely mastered at the age of 8. Differences among the concessive connectives studied were brought out: the item “quand même” obtained much better results than the other items with 8-year-old subjects; statements with “mais” seemed to be better processed in the conclusion task than in the context task, especially by 10-year-old subjects. These results are compared with other data obtained in some of the numerous studies on the production and comprehension of concessive connectives in various languages, and discussed from the point of view of argumentative theory.     

Improvement of mental imagery after prism exposure in neglect: a case study

Previous work has shown that various symptoms of unilateral neglect, including the pathological shift of the subjective midline to the right, may be improved by a short adaptation period to a prismatic shift of the visual field to the right. We report here the improvement of imagined neglect after prism exposure in a patient with a left unilateral neglect. Despite a strong neglect observed for mental images as well as for conventional tests, the mental evocation of left-sided information from an internal image of the map of France map was fully recovered following prism adaptation to the right. This improvement could not be explained by the alteration of visuomotor responses induced by the prism adaptation. Prism adaptation may therefore act not only on sensory-motor levels but also on a higher cognitive level of mental space representation and/or exploration.