Could stress cause psychosis in individuals vulnerable to schizophrenia?

It has long been considered that psychosocial stress plays a role in the expression of symptoms in schizophrenia (SZ), as it interacts with latent neural vulnerability that stems from genetic liability and early environmental insult. Advances in the understanding of the neurobiology of the stress cascade in both animal and human studies lead to a plausible model by which this interaction may occur: through neurotoxic effects on the hippocampus that may involve synaptic remodeling. Of late, the neurodevelopmental model of SZ etiology has been favored. But an elaboration of this schema that credits the impact of postnatal events and considers a role for neurodegenerative changes may be more plausible, given the evidence for gene-environment interaction in SZ expression and progressive structural changes observed with magnetic resonance imaging. Furthermore, new insights into nongliotic neurotoxic effects such as apoptosis, failure of neurogenesis, and changes in circuitry lead to an expansion of the time frame in which environmental effects may mediate expression of SZ symptoms.     

Affect as information in persuasion: a model of affect identification and discounting

Three studies examined the implications of a model of affect as information in persuasion. According to this model, extraneous affect may have an influence when message recipients exert moderate amounts of thought, because they identify their affective reactions as potential criteria but fail to discount them as irrelevant. However, message recipients may not use affect as information when they deem affect irrelevant or when they do not identify their affective reactions at all. Consistent with this curvilinear prediction, recipients of a message that either favored or opposed comprehensive exams used affect as a basis for attitudes in situations that elicited moderate thought. Affect, however, had no influence on attitudes in conditions that elicited either large or small amounts of thought.     

Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice

Neural mechanisms underlying the regulation of ingestive behavior and energy balance are well conserved among mammals. Many neural pathways, each reflecting the function of many genes, interact to regulate these processes. Systematic genetic perturbations are not feasible in humans--the examination of gene functions relevant to feeding regulation must be performed in other species. Many advances in this field have been made through molecular genetic studies of mice, the most genetically tractable of mammalian species. The relevance of mouse ingestive behavior to the mechanisms underlying the regulation of feeding in humans is discussed. Approaches for evaluating the contributions of genes to the regulation of energy balance and to the actions of anorectic drugs are described in the context of studies focused on a line of mice lacking the serotonin 5-HT2C receptor subtype. These animal display reduced responsiveness to serotonergic anorexic drugs and a late-onset obesity syndrome associated with features reminiscent of common forms of human obesity. Developmental studies of energy balance uncovered a novel age-dependent physiological process that may contribute generally to the predisposition of humans and other mammals to accumulate fat stores during "middle-age." These findings are presented to illustrate considerations in the use of mouse molecular genetic technologies to investigate genetic influences on ingestive behavior and energy balance.     

The sleeper effect in persuasion: a meta-analytic review

A meta-analysis of the available judgment and memory data on the sleeper effect in persuasion is presented. According to this effect, when people receive a communication associated with a discounting cue, such as a noncredible source, they are less persuaded immediately after exposure than they are later in time. Findings from this meta-analysis indicate that recipients of discounting cues were more persuaded over time when the message arguments and the cue had a strong initial impact. In addition, the increase in persuasion was stronger when recipients of discounting cues had higher ability or motivation to think about the message and received the discounting cue after the message. These results are discussed in light of classic and contemporary models of attitudes and persuasion.     

Centrality ratings,forensic relevance,and production frequency: Which one best identifies central and peripheral items?

Production frequency has often been used to identify central and peripheral information, under the assumption that high frequency implies that the item is central. However, no research to date has tested the relationship between centrality and frequency. Participants watched a video of a bank robbery and completed a free recall test, from which frequency for recalled items was computed. Two groups then watched the same video and rated centrality and forensic relevance for each item. Results showed that most, but not all, items with high frequency were rated as central and forensically relevant but that low frequency items were not diagnostic of either item centrality or forensic relevance. Forensic relevance was a better indicator of item centrality than frequency. We concluded that frequency measures should be avoided to determine centrality. Also, if centrality ratings cannot be collected, forensic relevance ratings may be more appropriate for this purpose.     

Validation scheme and procedures to analyze consequential validity

The argument-based validation scheme guides assessment of the consequences of testing. The distinction between semantic inference and political inference allows us to combine the validation of the consequences in a single validation scheme. The validation process should produce evidence about the assumptions that support both types of inference. After presenting the validation scheme, we provide examples of its use in the assessment of the testing of two applications: the use of high-stake tests in educational contexts and the validation of adjustments made in standardized tests for people with disabilities. Finally, we propose procedures for the validation of consequences and we discuss the suitability of the argument-based validation scheme for the validation of the consequences of testing in Spain.     

Nature, decay, and spiraling of the effects of fear-inducing arguments and HIV counseling and testing: a meta-analysis of the short- and long-term outcomes of HIV-prevention interventions.

OBJECTIVE: To examine the long-term efficacy of both fear-inducing arguments and HIV counseling and testing at encouraging and maintaining knowledge about HIV transmission and prevention, as well as condom use. DESIGN: Analyses were conducted with a sample of 150 treatment groups and 34 controls and included measures of change at an immediate follow-up and a delayed follow-up. MAIN OUTCOME MEASURES: The main outcome measures were perceived risk of HIV infection, knowledge about HIV, and condom use. RESULTS: Results indicated that receiving fear-inducing arguments increased perceptions of risk at the immediate follow-up but decreased knowledge and condom use, whereas resolving fear via HIV counseling and testing decreased perceptions of risk and increased knowledge and condom use at both the immediate and delayed follow-ups. The effects on perceived risk [corrected] decreased over time, but the effects on knowledge [corrected] condom use became more pronounced. CONCLUSION: Inducing fear is not an effective way to promote HIV-relevant learning or condom use either immediately following the intervention or later on. However, HIV counseling and testing can provide an outlet for HIV-related anxiety and, subsequently, gains in both knowledge and behavior change immediately and longitudinally.     

Who participates in which health promotion programs? A meta-analysis of motivations underlying enrollment and retention in HIV-prevention interventions

This meta-analysis examines whether exposure to HIV-prevention interventions follows self-validation or risk-reduction motives. The dependent measures used in the study were enrolling in an HIV-prevention program and completing the program. Results indicated that first samples with low prior condom use were less likely to enroll than samples with high prior condom use. Second, samples with high knowledge were less likely to stay in an intervention than were those with low knowledge. Third, samples with medium levels of motivation to use condoms and condom use were more likely to complete an intervention than were those with low or high levels. Importantly, those patterns were sensitive to the interventions' inclusions of information-, motivation-, and behavioral-skills strategies. The influence of characteristics of participants, the intervention, and the recruit procedure are reported.     

Adapting Homework for an Older Adult Client With Cognitive Impairment

There is growing evidence that psychosocial treatments incorporating behavioral intervention strategies can be effective in the treatment of depression in older adults with cognitive impairment. However, less work with such cases has focused on the use of cognitive interventions in tandem with these behavioral intervention strategies. This case study describes how cognitive behavioral intervention strategies and related homework assignments were tailored and integrated to successfully treat depressive symptoms in an older African American diagnosed with probable Alzheimer’s disease. Examples of the homework strategies utilized are introduced by phase of treatment. We also discuss ways to overcome barriers to homework completion as well as methods to incorporate the client’s sociocultural context and personal history into homework.     

Event-related potential correlates of visual identity negative priming unbiased by trial-by-trial effects

Negative priming (NP) refers to slowed reaction times and/or less accurate responses in people responding to a target that was ignored on a previous trial. Although extensive research with behavioral measures has been conducted, little is known about the electrophysiological mechanisms underlying this effect. The few previous studies carried out have led to contradictory results, supporting either episodic-retrieval or inhibition-based theoretical perspectives. In this study, we analyzed the ERP correlates of negative priming by using an experimental global context which, similar to the NP standard context, included Attended repetition trials. In addition, we presented relevant stimuli in separate blocks instead of the more usual randomized design. The NP effect can be biased by strategies adopted by participants when attended and ignored repetition trials are presented randomly. Specifically, we observed an enhanced N2 when a distractor from the previous trial became the target in the next trial. It is supposed that this finding reflects the involvement of additional attentional resources in the selection of a previously inhibited distractor as the new target stimuli.