Semantic clustering as a neuropsychological predictor for amnestic-MCI

Recent research has demonstrated that patients with Alzheimer's disease (AD) show deficits in semantic processing when compared to cognitively healthy individuals. This difference is thought to be attributed to losses in higher cortical systems that are predominantly associated with executive functioning. The first aim of the study will be to determine if differences in semantic clustering can accurately differentiate patients with amnestic mild cognitive impairment (aMCI) from cognitively normal (CN) individuals. The second aim will be to determine the extent to which semantic processing might be associated with executive functions. Data from 202 (134 CN, 68 aMCI) participants were analyzed to quantify differences in semantic clustering ratios on the HVLT-R. Study participants ages ranged from 51 to 87 with education ranging from 6 to 20 years. ANCOVA revealed statistically significant differences on semantic clustering ratios (p < .001). Moderate correlations between semantic clustering Category Fluency Test (r = .45) were also found. Statistically significant group differences were also present on Trails-B and WAIS-R Digit Symbol performance (p < .001). Overall, these data indicate that deficits in semantic clustering are present in aMCI patients.     

A Mobile Colonoscopic Unit for Lynch Syndrome: Trends in Surveillance Uptake and Patient Experiences of Screening in a Developing Country

The Genetic and Endoscopic Surveillance Clinic is an annual outreach service offering accessible colonoscopic surveillance to known families with Lynch syndrome living in remote areas of the Western and Northern Cape Province of South Africa. Unfortunately attendance at this outreach clinic has been declining over several years and fewer than a quarter of participants, attending for surveillance, have been adherent with all their recommended screening appointments. Concerns exist for non-adherent individuals as screening can prevent colorectal cancer by removing the precancerous lesion or enabling the treatment of a malignancy at an early stage. This study explored the experience of surveillance from both the non-adherers’ and adherers’ perspectives and identified unique factors affecting attendance at the outreach clinic. Rates of compliance are calculated for 191 mutation-positive cases of Lynch syndrome, using strict attendance criteria, and compared to figures obtained from self-reported attendance. Non-compliance was under-reported and compliance was exaggerated when basing data on self-reported adherence to recommendations. Specific characteristics of the outreach clinic affecting compliance are identified and recommendations are made to facilitate improvements to the service. These improvements can result in increased compliance with screening regimens and ultimately reduce cancer-related mortality.     

Death‐contemplation and contemplative living: Socrates and the Katha Upanishad

This paper seeks to argue that Socrates’ thought on the connection between death‐contemplation and genuine philosophising as reported in Plato's Phaedo, is comparable in many ways to the insight on the same connection contained in the Katha Upanishad. While refraining from a general comparison of the Platonic and the Upanishadic systems, the paper attempts to show, through an original exposition of Phaedo as well as the Katha Upanishad, that both these classics emphasise the value of death‐contemplation for a thoughtful and fundamental assessment of human existence, which is but a genuine task of philosophy.     

Why is Gandhi Wise? A Cross-Cultural Comparison of Gandhi as an Exemplar of Wisdom

This study explores cross-cultural differences in why Mohandas (Mahatma) Gandhi is nominated as an historical exemplar of wisdom. We compare the answers of emerging adults (aged 18–30) from three populations: Indian citizens, Canadian citizens, and Indian immigrants to Canada. Chi-square analyses showed that these groups emphasize significantly different aspects of Gandhi’s wisdom: Canadian citizens see Gandhi’s wisdom as practical and intellectual; Indian citizens see Gandhi’s wisdom as practical and benevolent; Indian immigrants to Canada consider Gandhi to integrate benevolent, intellectual, and practical aspects of wisdom; they also differ significantly in attributes associated with their implicit theory about his wisdom. Participants who know more about Gandhi also claim that he had a greater impact on their own lives. These findings suggest that historical exemplars of wisdom are filtered through the sociocultural contexts of each participant’s own lived experience, but that they still can be an inspiration in personally meaningful ways.     

Professional Issues of International Genetic Counseling Students Educated in the United States

International students have unique personal and academic challenges during their training in genetic counseling programs across the United States (U.S.). Previous research has explored their motivations and experiences; however, there is scant research on how their international status affects the post-graduate experience. The current study used semi-structured phone interviews to explore the professional issues that international students face throughout their educational and professional careers. Twenty-six participants were interviewed including international genetic counseling students in their second years of training and international genetic counselors who graduated from a U.S.-accredited program. Participants included six, second-year students, twelve genetic counselors employed in the U.S., six employed in Canada, and one employed in the United Kingdom (U.K.). Qualitative analysis of interviews captured the common experiences and challenges international students faced during their training and post-graduation. Participants stated that they applied to programs in the U.S. because there is wide transferability of qualifications across the world, and there is limited or no opportunities for masters level genetic counseling training in their home country. Most participants who had applied for jobs in the U.S. experienced difficulties regarding unfamiliarity of human resources (HR) departments and Border Control Officers with international genetic counselors (GCs) and their visa requirements. The results suggest that currently there are insufficient job resources tailored to international genetic counselors, and an inadequate availability of peer support. The results also speak to the need to develop resources for prospective international students and for international GCs seeking jobs, and establishment of a peer support network. These resources may also provide assistance to genetic counseling training programs and employers to address the challenges faced by international genetic counselors.     

After justification: Toward a Dalit public Lutheran theology

The aim of this article is to construct a “Dalit public Lutheran theology” as an “after‐justification” conversation, which drafts an agenda for the future of Lutheran theology in the twenty‐first century. In moving toward that construction, I first briefly explain Dalit theology, public theology, and Lutheran theology and shall discuss the rationale for a Dalit public Lutheran theology. From there I propose that Lutheran theology needs to take a contextual, post‐colonial and subaltern turn. Then I discuss the contours of Dalit public Lutheran theology by discussing one of the pivotal doctrine of Luther, “justification by grace through faith,” by engaging in a Dalit public discourse and propose “hospitality by love” as what comes after justification. Finally, I bring out the relevance of such a theology for our present‐day context. The method I employ in this article is subaltern methodology, which is to “read from below” or “read against the grain.” “After justification” is understood as “beyond” the understanding of doctrine of justification, as a forward‐looking public theological understanding of justification, where it finds fecundity and validity.     

Thinking graphically: Connecting vision and cognition during graph comprehension

Task analytic theories of graph comprehension account for the perceptual and conceptual processes required to extract specific information from graphs. Comparatively, the processes underlying information integration have received less attention. We propose a new framework for information integration that highlights visual integration and cognitive integration. During visual integration, pattern recognition processes are used to form visual clusters of information; these visual clusters are then used to reason about the graph during cognitive integration. In 3 experiments, the processes required to extract specific information and to integrate information were examined by collecting verbal protocol and eye movement data. Results supported the task analytic theories for specific information extraction and the processes of visual and cognitive integration for integrative questions. Further, the integrative processes scaled up as graph complexity increased, highlighting the importance of these processes for integration in more complex graphs. Finally, based on this framework, design principles to improve both visual and cognitive integration are described.     

Influence of precipitation of intermetallics on Young's modulus in nickel and zirconium base alloys

The influence of precipitation of intermetallic phases on changes in Young's modulus in nickel and zirconium base alloys is discussed. This study shows clearly for the first time that the change in the modulus due to precipitation of intermetallic phases in these alloys is essentially governed by the change in the modulus of the matrix due to removal of precipitation forming elements, and not by the modulus of the precipitated intermetallics or the matrix/intermetallic interface.