Serotonin Depletion Does Not Prevent Intrinsic Sensitization in the Leech

Intrinsic sensitization is a form of behavioral facilitation that is distinct from the extrinsic sensitization normally studied. To examine whether intrinsic and extrinsic sensitization are mediated by different physiological processes, the effects of 5,7-dihydroxytryptamine-induced serotonin (5-HT) depletion on intrinsic sensitization of the leech whole-body shortening response were observed. Previous experiments have shown that 5-HT depletion disrupts dishabituation and extrinsic sensitization of this behavior in the leech. Intrinsic sensitization was observed in preparations from both control and 5-HT-depleted animals, indicating that this form of behavioral facilitation was not affected by 5-HT depletion. The differences in the effects of 5-HT depletion on intrinsic versus extrinsic sensitization suggest that there are distinct neurophysiological processes mediating these two forms of behavioral facilitation. In addition, 5-HT depletion appeared to disrupt a putative extrinsic form of habituation of the shortening reflex. These data support the hypothesis that both intrinsic and extrinsic processes of neuromodulation mediate habituation and sensitization.     

Synaptic Reliability Correlates with Reduced Susceptibility to Synaptic Potentiation by Brain-Derived Neurotrophic Factor

Recent studies have implicated brain-derived neurotrophic factor (BDNF) in use-dependent modification of hippocampal synapses. BDNF can rapidly potentiate synaptic transmission at glutamatergic synapses by enhancing transmitter release. Using simultaneous perforated patch recording from pairs and triplets of glutamatergic hippocampal neurons, we have examined how the initial state of the glutamatergic synapse determines its susceptibility to synaptic modification by BDNF. We found that the degree of synaptic potentiation by BDNF depends on the initial reliability and strength of the synapse: Relatively weak connections were strongly potentiated, whereas the effect was markedly reduced at stronger synapses. The degree of BDNF-induced potentiation strongly correlated with the initial coefficient of variation (CV) of the amplitude of excitatory postsynaptic currents (EPSCs) and inversely correlated with the initial paired–pulse facilitation, suggesting that synapses with lower release probability (P_r) are more susceptible to the action of BDNF. To determine whether saturation of P_r could have masked the potentiation effect of BDNF in the stronger synapses, we lowered the initial P_r either by reducing the extracellular Ca²⁺ concentration ([Ca²⁺]_o) or by bath application of adenosine. Synapses that were initially strong remained unaffected by BDNF under these conditions of reduced P_r. Thus, the lack of BDNF effect on synaptic efficacy cannot simply be accounted for by saturation of P_r, but rather may be due to intrinsic changes associated with synaptic maturation that might covary with P_r. Finally, the dependence on initial synaptic strength was also found for divergent outputs of the same presynaptic neuron, suggesting that synaptic terminals with different degrees of responsiveness to BDNF can coexist within in the same neuron.     

现行《医疗事故处理办法》的修改探析

现行《医疗事故处理办法》颁布实施１０ 年之久,新形势下需要对其进行修改和完善。“办法”的修改应该体现平等保护医患双方合法权益原则,合理界定医疗事故范围,调整医疗事故鉴定委员会的组成,建立完善的证据管理制度,明确医疗事故损失赔偿的范围和额度。     

Unification of models for choice between delayed reinforcers.

Two models for choice between delayed reinforcers, Fantino's delay-reduction theory and Killeen's incentive theory, are reviewed. Incentive theory is amended to incorporate the effects of arousal on alternate types of behavior that might block the reinforcement of the target behavior. This amended version is shown to differ from the delay-reduction theory in a term that is an exponential in incentive theory and a difference in delay-reduction theory. A power series approximation to the exponential generates a model that is formally identical with delay-reduction theory. Correlations between delay-reduction theory and the amended incentive theory show excellent congruence over a range of experimental conditions. Although the assumptions that gave rise to delay-reduction theory and incentive theory remain different and testable, the models deriving from the theories are unlikely to be discriminable by parametric experimental tests. This congruence of the models is recognized by naming the common model the delayed reinforcement model, which is then compared with other models of choice such as Killeen and Fetterman's (1988) behavioral theory of timing, Mazur's (1984) equivalence rule, and Vaughan's (1985) melioration theory.     

Metaphysics of causation

Conclusion The world contains not only causes and effects, but also causal relations holding between causes and effects. Because causal relations enter into the structure of the world, their presence has various modal and probabilistic consequences. Causation and necessary and sufficient conditions do often go hand in hand. Causation, however, is a robust ingredient within the world itself, whereas modalities and probabilities supervene on the nature of the world as a whole, and on the resulting relations between one possible world and others. Some modalities, therefore, are essentially causal; but causation is not essentially modal.¹⁹     

A reason for theoretical terms

The presence of nonobservational vocabulary is shown to be necessary for wide application of a conservative principle of theory revision.Support for this research was provided by the Office of Naval Research under contract No. N00014-87-K-0401. We thank Daniel Andler and Clark Glymour for helpful discussion.     

Evaluation of visual display surfaces by real users early in the design stage

Groups of non-computer scientists were tested to evaluate the potential of an as yet non-existent interactive terminal with a screen diagonal of one meter. A simulated large image terminal provided limited realistic interactions using software developed to give close proximity to the predicted visual effect. Subjective responses from 101 subjects were elicited from a questionnaire designed to evaluate specific aspects of the “terminal” in use. From this data, two types of screen (lenticular and plain) and two types of interaction devices (touch and remote pointer) were analyzed experimentally using a two-way factorial design. Potential end-users provided positive feedback concerning future use of the Large Image Terminal. Building a realistic mock-up revealed screen contaminations which would not have been discovered until a much later stage. Although statistical analysis of screen evaluations was equivocal, the questionnaire was sufficiently penetrating to separate the positive and negative features. This methodology was invaluable in guiding the design process. Copies of the questionnaire may be obtained from the authors at the Heriot-Watt address.     

Continuous opportunity for reinforcing brain stimulation

The performance of a rat provided with continuous opportunity to obtain reinforcing brain stimulation over a 20-day period is described in detail. The animal averaged 29.2 responses per min during the entire time. Testing session was terminated by experimenters, but a day-by-day analysis of behavior provided no evidence that the animal would have stopped responding.