Biotechnologies that empower transgender persons to self-actualize as individuals,partners, spouses,and parents are defining new ways to conceive a child: psychological considerations and ethical issues

Today, thanks to biomedical technologies advances, some persons with fertility issues can conceive. Transgender persons benefit also from these advances and can not only actualize their self-identified sexual identities but also experience parenthood. Based on clinical multidisciplinary seminars that gathered child psychiatrists and psychoanalysts interested in the fields of assisted reproduction technology (ART) and gender dysphoria, philosophers interested in bioethics, biologists interested in ART, and endocrinologists interested in pubertal suppression, we explore how new biotechnical advances, whether in gender transition or procreation, could create new ways to conceive a child possible. After reviewing the various medical/surgical techniques for physical gender transition and the current ART options, we discuss how these new ways for persons to self-actualize and to experience parenthood can not only improve the condition of transgender persons (and the human condition as a whole through greater equity) but also introduce some elements of change in the habitual patterns of thinking especially in France. Finally, we discuss the ethical issues that accompany the arrival of these children and provide creative solutions to help society handle, accept, and support the advances made in this area.     

Agreements between neighbours. The ‘ugody’ as a source on Jewish-Christian relations in early modern Poland

The following essay studies the importance of formal agreements (ugody or kontrakty) between representatives of Jewish communities and Christian burghers in early modern Poland. As a specific genre of legal document, these agreements, or contracts, are a unique source for understanding Jewish-Christian relations and the integration of Jews into local social fabrics. These contracts also reflect the importation and continuity of legal traditions that originated in German territories and arrived in Eastern Central Europe, and they corroborate suggestions that there was significant improvement in the legal status of the Jews in Eastern Europe as opposed to that under which they previously had lived in the West. The ugody document, finally, the emergence of what I have called elsewhere the contractual character of Polish-Jewish relations in the early modern period. (See François Guesnet, “Politik der Vormoderne—Shtadlanut am Vorabend der polnischen Teilungen,” Jahrbuch des Simon-Dubnow-Instituts 1 (2002), pp. 235–255, and more recently idem, “Political Culture of Polish Jewry: A Tour d’Horizon,” Report of the Oxford Centre for Hebrew and Jewish Studies 2007–2008, pp. 61–76, 67–68.)     

Immigrant children's peer acceptance and victimization in kindergarten: The role of local language competence

The study investigates peer acceptance and victimization of immigrant and Swiss children in kindergarten classes. Our first aim is to compare peer acceptance and victimization of Swiss and immigrant children. Secondly, we explore the role of their local language competences (LLCs). The sample was drawn from kindergartens in communities in the German‐speaking part of Switzerland. A representative sample of 568 boys and 522 girls (mean age 5.8 years) took part in the research. Teachers completed questionnaires on children's victimization, bullying, and LLC. The nationality background of parents was indicated by teachers and parents. To assess peer acceptance, a peer nomination method was used. Immigrant children showed less acceptance by peers and were more often victimized than their Swiss peers. There was a significant interaction effect for LLC and national background of mothers, showing that LLC was positively associated with peer acceptance for children of an immigrant background but not for Swiss children. Furthermore, peer acceptance mediated the effect of national background of mothers on victimization. Results are discussed in terms of the need to improve immigrant children's LLC.     

Are emotion regulation difficulties a moderator in the relationship between dating abuse and body investment in eating disorders?

IntroductionIt is well known that eating disorders (EDs) are related to intimacy difficulties and to previous adverse experiences; however, little is known about dating abuse and how this kind of abuse is related to the different facets of body investment and emotion regulation difficulties in EDs. This study aimed to evaluate the presence of dating abuse in ED outpatients and to evaluate the moderating role of difficulties in emotion regulation in the relationship between dating abuse and the different facets of body investment.MethodSixty-four ED outpatients (95.3% females; aged from 15 to 30 years) completed self-report measures regarding dating abuse, body investment, difficulties in emotion regulation, and ED symptoms.ResultsApproximately 89% of ED outpatients identified a current or past dating relationship. Of those, 51 (89.5%) reported at least one episode of dating abuse perpetration, and 52 (91.2%) reported at least one episode of dating abuse victimization. Emotional abuse was the most reported type of dating abuse. High levels of dating abuse were related to elevated body care in participants with more difficulties in emotion regulation. The remaining models, incorporating the other facets of body investment, did not show significant moderating effects.DiscussionA substantial number of ED outpatients reported dating abuse. Pending longitudinal replication, body care may be used as a strategy to deal with dating abuse in the absence of more adaptive emotion regulation strategies.     

Readers’ use of source information in text comprehension

In two experiments, we examined the role of discrepancy on readers’ text processing of and memory for the sources of brief news reports. Each story included two assertions that were attributed to different sources. We manipulated whether the second assertion was either discrepant or consistent with the first assertion. On the basis of the discrepancy-induced source comprehension (D-ISC) assumption, we predicted that discrepant stories would promote deeper processing and better memory for the sources conveying the messages, as compared to consistent stories. As predicted, readers mentioned more sources in summaries of discrepant stories, recalled more sources, made more fixations, and displayed longer gaze times in source areas when reading discrepant than when reading consistent stories. In Experiment 2, we found enhanced memory for source–content links for discrepant stories even when intersentential connectors were absent, and regardless of the reading goals. Discussion was focused on discrepancies as one mechanism by which readers are prompted to encode source–content links more deeply, as a method of integrating disparate pieces of information into a coherent mental representation of a text.     

Kv4 potassium channels modulate hippocampal EPSP-spike potentiation and spatial memory in rats

Kv4 channels regulate the backpropagation of action potentials (b-AP) and have been implicated in the modulation of long-term potentiation (LTP). Here we showed that blockade of Kv4 channels by the scorpion toxin AmmTX3 impaired reference memory in a radial maze task. In vivo, AmmTX3 intracerebroventricular (i.c.v.) infusion increased and stabilized the EPSP-spike (E-S) component of LTP in the dentate gyrus (DG), with no effect on basal transmission or short-term plasticity. This increase in E-S potentiation duration could result from the combination of an increase in excitability of DG granular cells with a reduction of GABAergic inhibition, leading to a strong reduction of input specificity. Radioactive in situ hybridization (ISH) was used to evaluate the amounts of Kv4.2 and Kv4.3 mRNA in brain structures at different stages of a spatial learning task in naive, pseudoconditioned, and conditioned rats. Significant differences in Kv4.2 and Kv4.3 mRNA levels were observed between conditioned and pseudoconditioned rats. Kv4.2 and Kv4.3 mRNA levels were transiently up-regulated in the striatum, nucleus accumbens, retrosplenial, and cingulate cortices during early stages of learning, suggesting an involvement in the switch from egocentric to allocentric strategies. Spatial learning performance was positively correlated with the levels of Kv4.2 and Kv4.3 mRNAs in several of these brain structures. Altogether our findings suggest that Kv4 channels could increase the signal-to-noise ratio during information acquisition, thereby allowing a better encoding of the memory trace.     

Remodeling of the neuronal circuits underlying opiate-withdrawal memories following remote retrieval

Several types of memory display time-dependent reorganization of their underlying neural substrates, but it remains unclear whether affective memories associated with drug effects also follow similar reorganization. Here, we analyzed the neural circuits reactivated by the re-exposure of former dependent rats to the withdrawal-paired environment 1month after conditioning (remote memory) as compared with recent memory (Frenois, F., Stinus, L., Di Blasi, F., Cador, M., & Le Moine, C. (2005) A specific limbic circuit underlies opiate withdrawal memories The Journal of Neuroscience, 25, 1366-1374). C-fos expression showed that the circuits involved in the retrieval of withdrawal memories are partly different when comparing recent and remote reactivation, showing that, like other type of memories, affective memories linked to opiate withdrawal undergo anatomical reorganization, with a shift from extended amygdala regions toward cortical areas.     

Portuguese Validation of FACES-IV in Adult Children Caregivers Facing Parental Cancer

The purpose of the present study was to examine the psychometric properties of the FACES-IV in Portuguese caregivers of cancer patients. In this cross-sectional study, a sample of 214 adult children caregivers of cancer patients receiving chemotherapy, completed FACES-IV, Family Communication Scale (FCS), Family Satisfaction Scale (FSS), and Satisfaction with Social Support Scale (SSSS). Internal consistencies above .70 were found for all FACES-IV scales, except for Enmeshed and Rigid scales, as well as for the FCS, FSS, and SSSS (except for Intimacy). Strong correlations between FACES-IV and the validation scales FCS and FSS were found except for the Enmeshed and Rigid scales. Confirmatory analysis yielded an acceptable model for the six theoretical subscales. The discriminant analysis between problematic and non-problematic family systems showed results similar to the original study. These findings suggest that FACES-IV is a valid measure of family functioning in oncological family caregiving’s contexts.     

Creep behaviour of ice single crystals loaded in torsion explained by dislocation cross-slip

Torsion creep experiments are carried out in order to understand the physics of ice plasticity. A dislocation spreading mechanism based on double cross-slip of basal dislocations is proposed to explain the strong plastic anisotropy and the power law relationship between stress and strain rates. The scenario is tested using three-dimensional dislocation dynamics simulations. Numerical investigations give a stress exponent n?=?2.3 in agreement with experimental measurements. This dislocation spreading mechanism sheds a new light on the interpretation of former experimental observations.