Functional neuroanatomy of altered states of consciousness: the transient hypofrontality hypothesis

It is the central hypothesis of this paper that the mental states commonly referred to as altered states of consciousness are principally due to transient prefrontal cortex deregulation. Supportive evidence from psychological and neuroscientific studies of dreaming, endurance running, meditation, daydreaming, hypnosis, and various drug-induced states is presented and integrated. It is proposed that transient hypofrontality is the unifying feature of all altered states and that the phenomenological uniqueness of each state is the result of the differential viability of various frontal circuits. Using an evolutionary approach, consciousness is conceptualized as hierarchically ordered cognitive function. Higher-order structures perform increasingly integrative functions and thus contribute more sophisticated content. Although this implies a holistic approach to consciousness, such a functional hierarchy localizes the most sophisticated layers of consciousness in the zenithal higher-order structure: the prefrontal cortex. The hallmark of altered states of consciousness is the subtle modification of behavioral and cognitive functions that are typically ascribed to the prefrontal cortex. The theoretical framework presented yields a number of testable hypotheses.     

Enactments of Race in the UK’s Blood Stem Cell Inventory

Recent sociological analyses of the intersections of race and science recognise race’s quality as an enacted object. Through this analytic lens, race is always materialising in the practices and processes that enrol it and therefore enjoys a kind of multiplicity. The context of blood stem cell transplantation, a scientific domain marked by a more and less explicitly racialised logic, offers an opportunity to see the conceptual assertion of race’s multiplicity play out. Indeed, an exploration of the UK’s stem cell inventory reveals—through analysis of interviews, policy and parliamentary meetings—how race materialises in the various practices that comprise this increasingly popular cancer treatment option. Looking at practices of recruitment, inventory management and tissue selection in particular provides an interesting window to look upon race and the many signifiers that implicate it. These cases reveal moments of race’s stablisation and silencing; its oscillation between the status of vital information to the life of a public stem cell inventory, and of secondary data that provides little useful information to clinicians selecting tissue. Adopting an analytic lens that attends to race’s multiple enactments allows us to begin asking why enactments take the shape they do, and why the particular practices that mobilise them come to be.     

Personality and Legislative Politics: The Big Five Trait Dimensions Among U.S. State Legislators

The impact of personality traits on people's attitudes and behaviors is widely recognized, yet systematic attention to personality in large‐N research on elected officials has been rare. Among psychologists, five‐factor frameworks that focus on openness to experience, conscientiousness, extraversion, agreeableness, and emotional stability have gained tremendous prominence in the past two decades. Applications of these frameworks to the study of mass political behavior have been highly fruitful, but corresponding applications in the study of legislators have been rare. In an effort to assess the utility of a Big Five approach in the study of legislative politics, this article addresses three questions: whether elected officials will be willing to provide personality self‐assessments, whether any data they do provide will exhibit meaningful variance, and whether the Big Five trait dimensions will correspond with patterns in respondents' attitudes and behaviors. These questions are addressed using data from members of the state legislatures in Arizona, Connecticut, and Maine. Results provide considerable grounds for optimism regarding the likely utility of more extensive applications of the Big Five in research on elected officials.     

Media, Empowerment and the ‘Sexualization of Culture’ Debates

Claims about ‘empowerment’ increasingly animate debates about the ‘sexualization of culture’. This article responds to Lamb and Peterson’s (2011) attempts to open up and complicate the notion of ‘sexual empowerment’ as it is used in relation to adolescent girls. Drawing on contemporary research from the UK, New Zealand and elsewhere, the article seeks to promote a dialogue between media and communications research and more psychologically oriented scholarship. The paper makes four arguments. First it points to the need to rethink conceptualizations of the media, and processes of media influence. Secondly it raises critical questions about the notion of ‘media literacy’ which has increasingly taken on the status of panacea in debates about young people and ‘sexualization’. Thirdly it highlights the curious absence of considerations of power in debates about sexual empowerment, and argues for the need to think about sexualization in relation to class, ‘race’, sexuality and other axes of oppression. Finally, it raises critical questions about the utility of the notion of sexual empowerment, given its individualistic framing, the developmentalism implicit in its use, and the difficulties in identifying it in cultures in which ‘empowerment’ is used to sell everything from liquid detergents to breast augmentation surgery.     

Differences in Scope Assignments for Child and Adult Speakers of Mandarin

The present study used a Truth Value Judgment Task to investigate whether changes in sentence structure lead to corresponding changes in the assignment of scope relations by Mandarin-speaking children and adults. In one condition, participants were presented with ordinary negative sentences containing disjunction; this condition was designed to verify the existing claim that disjunction is a positive polarity item for adult speakers of Mandarin, but not for child speakers. In a second condition, participants were presented with negative sentences where the disjunction phrase was preposed from object position; this condition was designed to examine the extent to which changes in sentence structure can result in changes in scope assignments to negated disjunctions. The results indicate that the preposed disjunction phrase undergoes reconstruction for children, whereas reconstruction is blocked for adults. This finding also suggests that Mandarin-speaking children and adults exhibit different scope preferences for negated disjunctions, regardless of where the disjunction phrase appears in the surface syntax.     

Making the case for objective performance metrics in newborn screening by tandem mass spectrometry

The expansion of newborn screening programs to include multiplex testing by tandem mass spectrometry requires understanding and close monitoring of performance metrics. This is not done consistently because of lack of defined targets, and interlaboratory comparison is almost nonexistent. Between July 2004 and April 2006 (N=176,185 cases), the overall performance metrics of the Minnesota program, limited to MS/MS testing, were as follows: detection rate 1:1,816, positive predictive value 37% (54% in 2006 till date), and false positive rate 0.09%. The repeat rate and the proportion of cases with abnormal findings actually been reported are new metrics proposed here as an objective mean to express the overall noise in a program, where noise is defined as the total number of abnormal results obtained using a given set of cut-off values. On the basis of our experience, we propose the following targets as evidence of adequate analytical and postanalytical performance: detection rate 1:3,000 or higher, positive predictive value>20%, and false positive rate<0.3%.     

Experimentation with Group Techniques with Ego-Disturbed Mothers

Abstract

Psycho–educational groups (PEGs) have been shown to be a particularly effective form of treatment for patients classified under the rubric of severely and persistently mentally ill (SPMI). However, recent surveys suggest that certain professionals, such as nurses and clinical psychologists, called on to conduct these groups may have limited to no training. This study tested three methods (self–instructional, workshop, and workshop plus clinical supervision) designed to provide on-the-job training to practicing clinicians. Specifically, training was based on two manuals; one that operationalized the basic knowledge and skills needed to run an effective PEG and the second being a commonly used PEG program for symptom management targeted at SPMI patients. Eight nurses from four adult units at a state psychiatric hospital initially received self–instructional or workshop training and then conducted a 12–session symptom management PEG composed of four to five SPMI patients (e.g., schizophrenia, schizoaffective or major depression disorders). In a second wave of additional training, nurses received workshop training or clinical supervision and then conducted a second PEG. Differences between training methods were assessed by nurse– and patient–completed measures that tapped the knowledge and skills emphasized in the symptom management and PEG (nurses only) manuals. Results indicated limited support for the superiority of the workshop method on the nurse measures alone. Implications for training working professionals in group treatments and assessing outcomes with chronic SPMI patients are discussed.