New anticonvulsant medication uses in bipolar disorder

Therapy of bipolar disorders is a rapidly evolving field. Lithium has efficacy in classic bipolar disorders whereas divalproex sodium and carbamazepine may have broader spectrum efficacy that includes non-classic bipolar disorder. In the last 10 years, a series of anticonvulsants have been approved for marketing in the United States. Gabapentin has indirect g-aminobuytric acid-ergic actions, is generally well tolerated, and appears to have anxiolytic, analgesic, and hypnotic effects. Lamotrigine has antiglutamatergic actions and is generally well tolerated (aside from rash in 1 in 10, and serious rash in 1 in 1,000 patients). Lamotrigine is indicated for maintenance treatment in bipolar disorder. Emerging evidence suggests lamotrigine may have utility in bipolar disorder patients with depression and treatment-refractory rapid cycling, as well as analgesic effects. Topiramate and zonisamide may allow both weight loss, while topiramate may have specific efficacy in bulimia, binge eating disorder, and alcohol dependence. Two small studies found oxcarbazepine had similar efficacy to lithium and haloperidol in acute mania. Phenytoin, an older anticonvulsant, may have adjunctive acute mania efficacy. Levetiracetam, a newer anticonvulsant, may be worth exploring and has minimal drug-drug interactions. None of these newer agents has been shown effective in a large placebo controlled trial for acute mania. Although the clinical profiles of these newer anticonvulsants do not appear to overlap markedly with divalproex and carbamazepine (except perhaps for oxcarbazepine), these novel agents may still offer important new options in relieving a variety of specific target symptoms in patients with bipolar disorder.     

How meta-analysis increases statistical power

One of the most frequently cited reasons for conducting a meta-analysis is the increase in statistical power that it affords a reviewer. This article demonstrates that fixed-effects meta-analysis increases statistical power by reducing the standard error of the weighted average effect size (T.) and, in so doing, shrinks the confidence interval around T.. Small confidence intervals make it more likely for reviewers to detect nonzero population effects, thereby increasing statistical power. Smaller confidence intervals also represent increased precision of the estimated population effect size. Computational examples are provided for 3 effect-size indices: d (standardized mean difference), Pearson's r, and odds ratios. Random-effects meta-analyses also may show increased statistical power and a smaller standard error of the weighted average effect size. However, the authors demonstrate that increasing the number of studies in a random-effects meta-analysis does not always increase statistical power.     

Using temporal information to construct, update, and retrieve situation models of narratives

Four experiments explored how readers use temporal information to construct and update situation models and retrieve them from memory. In Experiment 1, readers spontaneously constructed temporal and spatial situation models of single sentences. In Experiment 2, temporal inconsistencies caused problems in updating situation models similar to those observed previously for other dimensions of situation models. In Experiment 3, merely implied temporal order information was inferred from narratives, affecting comprehension of later sentences like explicitly stated order information. Moreover, inconsistent temporal order information prevented the creation and storage in memory of an integrated situation model. In Experiment 4, a temporal inconsistency increased processing time even if readers were unable to report the inconsistency. These results confirm the significance of the temporal dimension of situation models.     

Understanding Quine''s Famous `Statement''

I argue that Quine's famous claim, any statement can be held true come what may, demands an interpretation that implies that the meanings of the expressions in the held-true statement change. The intended interpretation of this claim is not clear from its context, and so it is often misunderstood by philosophers (and is misleadingly taught to their students). I explain Fodor and Lepore's (1992) view that the above interpretation would render Quine's assertion entirely trivial and reply, on both textual and philosophical grounds, that only this trivial reading is consistent with Quine's famous denial of analyticity. I also explain briefly how the trivial reading lends support to meaning holism, which, regardless of one's views of its consequences, is an important position in the philosophy of language and mind.     

Children as carers: the impact of parental illness and disability on children's caring roles

The nature and extent of young caring in the UK continue to be a feature of a growing number of research programmes motivated by a children and carers' rights philosophy. However, the context in which young caring occurs as a result of parental ill-health or disability can only be fully understood by examining the findings and implications of medical research into parental impairment, and the social movements that have served to re-define the concept of 'disability' in society. This paper examines the arguments put forward by medical researchers, by those proposing a social model of disability and by those who have specifically investigated the conditions and experiences of young carers. It argues that children's caring roles within families where there is parental illness or disability need to be understood not only as a reflection of the nature of the medical condition itself, but as a consequence of complex family, social and economic processes. A 'whole family' approach is proposed, where the needs of children and parents are respected and responded to.     

A comment on the functional localization of the phonological storage subsystem of working memory.

Working memory, as defined by Baddeley and Hitch, is an interactive set of cognitive processes responsible for holding information online and available for analysis. Part of that system is a specialized subsystem devoted to maintaining verbal information; the verbal "slave" subsystem has as a core component a phonological store. For many years, the anatomical locus of the phonological store has been thought to be in the supramarginal and angular gyri of the speech dominant hemisphere, and functional neuroimaging studies provide broad support for this localization. However, a finer grained analysis of published experiments reveals two possible foci for the phonological store within the parietal lobe, neither of which has a pattern of functional activation that is fully consistent with the Baddeley and Hitch model. The purpose of the present paper is to review several studies relevant to the question of the localization of the phonological store and to suggest possible reasons the results are discrepant.     

Rape Myths and Hookup Culture: An Exploratory Study of U.S. College Students' Perceptions

The present study provides the first known systematic examination of the association of hookup culture endorsement and rape myth acceptance. Multivariate regression analysis was conducted to test the primary hypothesis that hookup culture endorsement would be the primary predictor of rape myth acceptance levels among a sample of 422 U.S. college students. Findings indicated the existence of a complex relationship in which rape myth acceptance increases or decreases based upon the form of hookup culture endorsement examined. Beliefs that hookups are harmless and elevate social status increased rape myth acceptance, whereas beliefs that hookups express sexual freedom decreased rape myth acceptance. Furthermore, results supported the hypothesis that hookup culture endorsement was the largest predictor of rape myth acceptance. Consistent with previous studies, the predictive power of gender and religiosity in determining levels of rape myth acceptance were shown to be significant. When controlling for levels of hookup culture endorsement, the explanatory power of these variables decreased, and hookup culture endorsement had the largest effect upon rape myth acceptance levels.     

'Getting into the spirit': Alcohol-related interpretation bias in heavy-drinking students

Alcohol misuse is characterized by patterns of selective information processing. The present study investigated whether heavy- compared with light-drinking students, show evidence of an alcohol-related interpretation bias to ambiguous, alcohol-related cues. Toward this aim, participants were asked to create continuations for ambiguous, open-ended scenarios that provided either an alcohol-related or neutral context. Results showed that heavy-drinking students generated more alcohol continuations for ambiguous alcohol-related scenarios than light-drinking students. This result was independent of the coding method used, with an interpretation bias found when continuations were coded by either participants themselves or by two independent raters. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

“He Cursed, and I Got Angry:” Beliefs About Anger Among Adolescent Male Offenders in India

Cultural influences in the experience and expression of emotions have been widely recognized, although systematic studies of emotion-related beliefs in culturally diverse families have been scarce. The purpose of the present exploratory study was to examine beliefs about anger among a group of adolescent male offenders in India temporarily residing in a pre-sentencing institution. In particular, adolescent offenders (n = 14) were individually interviewed about their beliefs concerning causes and concomitants of, and behavioral responses to, one’s own and others’ anger, as well as family patterns of anger expression that are crucial in understanding socialization processes. Although some of the themes reflected in their narratives parallel the beliefs of educated, middle-class, non-offender youth in India (e.g., social inappropriateness of anger), as well as those of offenders in other parts of the world (e.g., aggressive behavior as a common response to anger), beliefs about various aspects of anger specific to this subculture of offender youth also emerged. In particular, perceived violations of family honor were cited as the most common elicitors of anger, and although anger was considered ‘bad’ it was expressed through aggression. The findings of this study highlight the need to develop a culturally informed theory of emotions, and relatedly, to develop culturally sensitive interventions for anger management that can be incorporated as a part of rehabilitation efforts for offender youth in India.     

Eye movements reveal sustained implicit processing of others' mental states

The ability to attribute mental states to others is crucial for social competency. To assess mentalizing abilities, in false-belief tasks participants attempt to identify an actor's belief about an object's location as opposed to the object's actual location. Passing this test on explicit measures is typically achieved by 4 years of age, but recent eye movement studies reveal registration of others' beliefs by 7 to 15 months. Consequently, a 2-path mentalizing system has been proposed, consisting of a late developing, cognitively demanding component and an early developing, implicit/automatic component. To date, investigations on the implicit system have been based on single-trial experiments only or have not examined how it operates across time. In addition, no study has examined the extent to which participants are conscious of the belief states of others during these tasks. Thus, the existence of a distinct implicit mentalizing system is yet to be demonstrated definitively. Here we show that adults engaged in a primary unrelated task display eye movement patterns consistent with mental state attributions across a sustained temporal period. Debriefing supported the hypothesis that this mentalizing was implicit. It appears there indeed exists a distinct implicit mental state attribution system.