Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference

Recently encoded information can be lost in the presence of new information, a process called 'retrograde interference'. Retrograde interference has been extensively described for more than a century; however, little is known about its underlying mechanisms. Different approaches agree on the need of the synthesis of plasticity related proteins (PRPs) to consolidate a long-term memory (LTM). Our hypothesis is that when PRPs are limited, interference of a task over LTM formation of another may be due to the utilization of protein resources common to both tasks. Here, by combining the tasks of inhibitory avoidance (IA) and open field (OF) exploration in rats, we show that memory traces compete for their stabilization if PRPs are limited. As a result, LTM is formed for only one of the tasks with a consequent decrease in the memory for the other. Furthermore, infusing Arc antisense oligonucleotide into the dorsal hippocampus, we found that Arc is necessary for LTM formation of these two types of learning tasks and is one of the PRPs that can be shared between them when animals are trained in both OF and IA. In sum, these findings suggest that under conditions of reduced protein availability, a learning task interferes with LTM formation of another by using the available PRPs.     

The many faces of autonomy

What does autonomy mean from a moral point of view? Throughout Western history, autonomy has had no less than four different meanings. The first is political: the capacity of old cities and modern states to give themselves their own laws. The second is metaphysical, and was introduced by Kant in the second half of the 18th century. In this meaning, autonomy is understood as an intrinsic characteristic of all rational beings. Opposed to this is the legal meaning, in which actions are called autonomous when performed with due information and competency and without coercion. This last meaning, the most frequently used in bioethics, is primarily legal instead of moral. Is there a proper moral meaning of the word autonomy? If so, this would be a fourth meaning. Acts can only be called moral when they are postconventional (using the terminology coined by Lawrence Kohlberg), inner-directed (as expressed by David Riesman), and responsible (according to Hannah Arendt). Such acts are autonomous in this new, fourth, and to my mind, the only one proper, moral meaning. The goal of ethics cannot be other than forming human beings capable of making autonomous and responsible decisions, and doing so because they think this is their duty and not because of any other nonmoral motivation, like comfort, convenience, or satisfaction. The goal of ethics is to promote postconventional and mature human beings. This was what Socrates tried to do with the young people of Athens. And it is also the objective of every course of ethics and of any process of training.     

Book Reviews

Abstract

The aim of this paper is to identify what I take to be the main conceptual problem in Lewis’ semantics for counterfactuals when the Limit Assumption (LA) is not satisfied, what I call the Discrimination Problem (DP), and to present and discuss a modification of Lewis’ semantics that aims at solving DP. First, I outline Lewis’ semantics, highlighting the aspects that will be relevant for our discussion. Second, I present DP and discuss it with a heuristic example. Third, I present the new proposal and comment some formal consequences and the objections they give rise to. Fourth, I present an allegedly equivalent version of the proposal and discuss the difference between counterfactuals and strict conditionals. Finally, I defend that the two proposals are different and argue for the first one as the best way of capturing two intuitions that seem in conflict when the LA is not satisfied. I conclude with a dilemma: either the proposal here defended works or LA is inescapable. Thus, if the proposal doesn’t work, the paper must then be considered as an indirect defense of the Limit Assumption.     

The I and World history in Hegel

In this paper, I investigate the relations between the notion of the I and the conception of World history in Hegel’s philosophy. First, I address Hegel’s account of the I by reconstructing its phenomenological and logical development from consciousness to self-consciousness through recognition with the other and arguing that the project of the Philosophy of Right is normative, as it provides an account of the logical process of affirmation of the I as the normative source of the realm of objective spirit. I then argue for an account of World history as the self-conscious development and liberation of the I in time and objectivity, and I consider Hegel’s philosophy of history in light of the Philosophy of Right as the historical emergence of the I through the forms of objective spirit in history. Finally, I focus on two of the allegedly most problematic issues related to Hegel’s conception of World history: the nature and very possibility of an ‘intersubjective consciousness’ and the notion of ‘World spirit’. I conclude by outlining how the conception of World history, if reconstructed in light of Hegel’s conception of the I, can have previously unnoticed political implications.     

Data presentation options to manage variability in physical activity research

This paper presents seven tactics for managing the variability evident in some physical activity data. High levels of variability in daily step‐count data from pedometers or accelerometers can make typical visual inspection difficult. Therefore, the purpose of the current paper is to discuss several strategies that might facilitate the visual interpretation of highly variable data. The seven strategies discussed in this paper are phase mean and median lines, daily average per week, weekly cumulative, proportion of baseline, 7‐day moving average, change point detection, and confidence intervals. We apply each strategy to a data set and discuss the advantages and disadvantages.     

The Arabic Origins of Romance Private Documents

The Christians who lived under Muslim rule in al-Andalus are known as Mozarabs. As immigrants from al-Andalus to the Christian kingdoms in the north, Mozarabs are depicted in current historiography as transmitters of Arabic and Muslim culture. Nevertheless, when the Mozarabs were observed by the Christian expansion southward, surprisingly, they are presented as isolated amidst the post-conquest order. Based on the case of Toledo, the first important city conquered by the kingdom of Castile in 1085, the present article shows how the Mozarabs had introduced Muslim notarial practices into the Christian society.     

Sport participation,body satisfaction and depressive symptoms in adolescence: a moderated-mediation analysis of gender differences

This research aimed to analyse the partial mediating role of body satisfaction in the relationship between sport participation and depressive symptoms, as well as to examine the moderating role of gender in these associations. A cross-sectional study was conducted with a sample of 1810 adolescents aged 13–18 years old who completed self-report measures regarding sport participation, body satisfaction and depressive symptoms. The results indicated that a higher frequency of sport participation was associated with a lower presence of depressive symptoms, both directly and through greater body satisfaction, although gender differences were found in this partial mediation model. It was detected that sport participation had a greater effect on positive body satisfaction among boys, whereas body dissatisfaction indicated a greater presence of depressive symptoms among girls. The results emphasize the need to implement gender-specific programmes to improve psychological adjustment in adolescents by promoting sport practice and body acceptance.     

Evaluating the effectiveness of goal setting and textual feedback for increasing moderate‐intensity physical activity in adults

The purpose of this study was to evaluate the effectiveness of goal setting and textual feedback, without additional intervention components, for increasing moderate‐intensity physical activity, specifically the weekly number of intense steps measured by a Fitbit. A multiple baseline across participants design was employed with four participants using a Fitbit Flex accelerometer to measure intense steps. Results showed a substantial increase in weekly number of intense steps for three out of four participants following the intervention.     

Response to bullying (RTB): Behavioral skills and in situ training for individuals diagnosed with intellectual disabilities

This study evaluated behavioral skills training (BST) and in situ training (IST) to teach a response to bullying (RtB) to four adults with intellectual disabilities who were victims of bullying. The RtB consisted of refraining from retaliating, stating disapproval, walking away, and telling a staff member. In situ assessments were conducted in the natural setting to assess the effects of BST and IST. BST alone was successful in teaching the RtB to two participants. When BST did not result in the use of the RtB, IST was effective for one participant, and IST plus an incentive was effective for the other participant. The results of this study are consistent with previous BST and IST research.