Effects of chronic cocaine administration on spatial learning and hippocampal spine density in two genetically different strains of rats

Lewis and Fischer-344 rats have been proposed as an addiction model because of their differences in addiction behaviour. It has been suggested that drug addiction is related to learning and memory processes and depends on individual genetic background. We have evaluated learning performance using the eight-arm radial maze (RAM) in Lewis and Fischer-344 adult rats undergoing a chronic treatment with cocaine. In order to study whether morphological alterations were involved in the possible changes in learning after chronic cocaine treatment, we counted the spine density in hippocampal CA1 neurons from animals after the RAM protocol. Our results showed that Fischer-344 rats significantly took more time to carry out test acquisition and made a greater number of errors than Lewis animals. Nevertheless, cocaine treatment did not induce changes in learning and memory processes in both strains of rats. These facts indicate that there are genetic differences in spatial learning and memory that are not modified by the chronic treatment with cocaine. Moreover, hippocampal spine density is cocaine-modulated in both strains of rats. In conclusion, cocaine induces similar changes in hippocampal neurons morphology that are not related to genetic differences in spatial learning in the RAM protocol used here.     

Individual characteristics and response to Contingency Management treatment for cocaine addiction

Voucher-based contingency management (CM) research has demonstrated efficacy for treating cocaine addiction, but few studies have examined associations between individual baseline characteristics and response to CM treatments. The aim of this study, involving 50 cocaine outpatients receiving CM for cocaine addiction, was to assess the impact of baseline characteristics on abstinence outcomes after six months of treatment. Patients who were abstinent after six months of treatment accounted for 58% of the sample. Patients with higher scores on the Alcohol area of the EuropASI and patients that were non-abstinent during the first month of treatment were less likely to achieve abstinence. These outcome predictors have implications both for treatment research and for clinical practice. Patients who do not respond early to treatment may need a more intensive intervention, and concomitant problematic alcohol use should be detected and treated. The remaining baseline variables examined were not statistically significant predictors of abstinence. This finding is important for the generalizability of CM across the range of individual characteristics of treatment-seeking cocaine abusers.     

Opening Scenarios: A Relational Perspective on How to Deal with Multiple Therapeutic Views

The aim of this work is to provide therapists with a conceptual outline to help them utilize theoretical and methodological perspectives from different psychotherapy models. More specifically, we will start with three basic assumptions from the social constructionist paradigm, particularly effective in bringing together different perspectives in therapy and providing therapists with useful criteria for selecting among them. The assumptions are as follows: (1) the psychological world of the individual is constructed within relational processes, mainly through dialogue; (2) in general, discourse can be classified as either generative or degenerative; and (3) individuals construct their life narratives based also on a common-sense that can derive from psychological theories developed within specific cultural traditions. These assumptions derive mainly from Gergen??s relational perspective (2009) and lead us to foresee a set of implications for clinical practice, where therapist and client are seen as ??multi-beings??, consequently endowed with multiple views, not one.     

Psychosocial predictors of relapse in cocaine-dependent patients in treatment

Relapses in cocaine abusers in treatment are an important problem. The majority of patients are incapable of sustaining abstinence over any length of time. To identify the factors associated to relapses risk in the cocaine use can be an optimal choice to improve the treatment strategies. The aim of this study was to analyze relapse-risk factors in cocaine-dependent patients on treatment. Participants were 102 patients who had begun outpatient treatment at a public health center in Spain. Some functional areas and cocaine use are evaluated for a period of six months. A structural equations model was used to identify possible predictive variables. The results show that social-family environment and economic-employment situation were associated with greater risk of relapse. Likewise, the social-family environment was related to severity of addiction. It is concluded that the incorporation of family intervention strategies and vocational/employment counseling may help to reduce relapse rates in cocaine addicts receiving treatment.     

How many lives can bloody and shocking road safety advertising save? The case of Spain

At the beginning of the 21st century, the punishment strategies used by the Spanish administration were considerably hardened to achieve a reduction in road accidents. This hardening could also be seen in the mass-media public advertising campaigns, with a marked shift from gentle messages to threat-based advertisements.The goal of this study is to evaluate the effectiveness of this radical change in terms of main road accident indicators and the time that the effects last using multivariate unobserved component models set up in a state space framework applied to monthly series for the 1980–2008 period. The main conclusion is that the effect on reducing road accidents is no greater when citizens are subjected to a greater level of threats in advertising campaigns than would on average be achieved using campaigns with a low level of threats. Secondly, the impact of bloody advertising in Spain is limited to the most serious accidents, those that cause deaths, either on highways or in built-up areas. Moreover, the positive effects progressively decrease as the average lifespan for significant effects of medium and high level campaigns on deaths on highways or in built-up areas was 8 months and almost 12 days. The results show that a reduction in numbers of deaths and injuries is always achieved when the level of harshness in the messages is increased after a period of several years of mild advertising.     

On the Mind Dependence of Truth

The claim that truth is mind dependent has some initial plausibility only if truth bearers are taken to be mind dependent entities such as beliefs or statements. Even on that assumption, however, the claim is not uncontroversial. If it is spelled out as the thesis that “in a world devoid of mind nothing would be true”, then everything depends on how the phrase ‘true in world w’ is interpreted. If ‘A is true in w’ is interpreted as ‘A is true of w’ (i.e. ‘w satisfies A’s truth conditions’, the claim need not be true. If on the other hand it is interpreted as ‘A is true of w and exists in w’ then the claim is trivially true, though devoid of any antirealistic efficacy. Philosophers like Heidegger and Rorty, who hold that truth is mind dependent but reality is not, must regard such principles as “A if and only if it is true that A” as only contingently true, which may be a good reason to reject the mind dependence of truth anyway.     

Depressed mothers’ infants show less negative affect during non-contingent interactions

Infants of depressed and non-depressed mothers were videotaped interacting with their mothers in the [Nadel, J., Carchon, I., Kervella, C., Marcelli, D., & Reserbat-Plantey, D. (1999). Report: Expectancies for social contingency in 2-month-olds. Developmental Science, 2, 164–173] paradigm which consists of three segments including: (1) a free play, contingent interaction, (2) a non-contingent replay of the mothers’ behavior that had been videotaped during the first segment, and (3) a return to a free play, contingent interaction. As compared to infants of non-depressed mothers, infants of depressed mothers showed less negative change (less increase in frowning) in their behavior during the non-contingent replay segment. This finding was interpreted as the infants of depressed mothers being more accustomed to non-contingent behavior in their mothers, thus experiencing less violation of expectancy in this situation.     

Cognitive control: dynamic, sustained, and voluntary influences

The cost of incongruent stimuli is reduced when conflict is expected. This series of experiments tested whether this improved performance is due to repetition priming or to enhanced cognitive control. Using a paradigm in which Word and Number Stroop alternated every trial, Experiment 1 assessed dynamic trial-to-trial changes. Incongruent trials led to task-specific reduction of conflict (trial n + 2) without cross-task modulation (trial n + 1), but this was fully explained by repetition priming. In contrast, an increased ratio of incongruent words did lead to sustained task-specific enhancement, above and beyond repetition priming (Experiment 2). Experiments 3 and 4 assessed the voluntary modulation of cognitive control: A cue predicted the congruency of the incoming trial, allowing participants to establish the correct mindset (Word Stroop in Experiment 3, Flanker task in Experiment 4). Preparing oneself to process an incongruent word (or flanker) enhanced conflict resolution in the subsequent Number Stroop, an example of cross-task modulation. Taken together, these experiments reveal the multifaceted aspects of conflict resolution: Trial-to-trial changes are often due to repetition priming; sustained modulations brought about by task demands are task specific; and voluntary modulations are task general.     

Neuropsychological performance in patients with fibromyalgia syndrome: relation to pain and anxiety

Previous studies have revealed the presence of cognitive impairment in patients with fibromyalgia syndrome (FMS). However, they have not determined the possible influence of the diverse clinical variables in these disturbances. The first aim of the current study is to compare the cognitive function of 81 patients with FMS and 35 healthy controls by means of a neuropsychological battery. The second aim is to determine the influence of anxiety and pain in the cognitive impairment of patients with FMS. The results of our study show that patients with FMS display a significantly lower cognitive performance and a significantly higher anxiety level than the healthy controls in all the parameters assessed. The neuropsychological performance in patients with FMS is associated with pain, and this relation was independent of the anxiety level. The relationship between cognitive performance and anxiety level was also significant. Therefore, we conclude that cognitive performance is primarily affected by pain. The level of anxiety explains part of the variability in neuropsychological tests that is not explained by pain.