Dysexecutive syndrome in Parkinson’s disease: the GREFEX study

The objectives of this study were to characterize the frequencies and profiles of behavioral and cognitive dysexecutive syndromes in PD (based on validated battery and diagnostic criteria) and to develop a shortened diagnostic battery. Eighty-eight non-demented patients with a diagnosis of PD were examined with an executive validated battery. Using a validated framework, the patients’ test results were interpreted with respect to normative data from 780 controls. A dysexecutive syndrome was observed in 80.6% of the patients [95% confidence interval: 71.1–90.1]. The dysexecutive profile was characterized by prominent impairments in deduction, flexibility, inhibition and initiation in the cognitive domain, and by global hypoactivity with apathy and hyperactivity in the behavioral domain. This finding implies that patients with PD should be assessed with cognitive tests and a validated inventory for behavioral dysexecutive syndromes. A shortened battery (based on three cognitive tests and three behavioral domains) provided high diagnostic accuracy.     

Time intervals production in tapping and oscillatory motion

We applied spectral analysis on series of time intervals produced in a synchronization-continuation experiment. In the first condition intervals were produced by finger tapping, and in the second by an oscillatory motion of the hand. Results obtained in tapping were consistent with a discrete, event-based timing model. In the oscillatory condition, the spectra suggested a continuous, dynamic timing mechanism, based on the regulation of effector stiffness. It is concluded that the oscillatory character of movement can offer an important resource for timing control. The use of an event-based timing control such as postulated in the Wing-Kristoffersson model could be restricted to a quite limited class of rhythmic tasks, characterized by the concatenation of discrete events.     

Monitoring processes and metamemory experience in patients with dysexecutive syndrome

The aim of the present study was to determine whether monitoring measures are differentially disturbed in dysexecutive patients after frontal lesions. Twelve dysexecutive patients and 12 healthy controls were administered a paired-associates learning task. Their performances on recall prediction, judgment-of-learning (JOL), and feeling-of-knowing judgment (FOK) were then compared. The results revealed that the two groups differed only on accuracy measures of the FOK paradigm. The study of the overall correlations between the three measures of metamemory revealed a significant relation between recall prediction and accuracy measures of the JOL. We failed to find any significant correlation with the accuracy measures of the FOK. Taken together, our data confirm that metamemory experience is not a unitary construct but rather a group of distinct and quite independent mechanisms.     

The Williams syndrome cognitive profile

Williams syndrome is a rare neurodevelopmental disorder caused by a hemizygous deletion of approximately 1.5 megabases on chromosome 7q11.23. In this article, we outline a Williams Syndrome Cognitive Profile (WSCP) that operationalizes the cognitive characteristics of the syndrome using measures of absolute and relative performance on subtests of the Differential Abilities Scales (Elliot, 1990a). Testing confirmed excellent sensitivity and specificity scores for the WSCP. Seventy-four of 84 individuals with Williams syndrome fit the WSCP while only 4 participants in a contrast group met all of the WSCP criteria. It was also found that the WSCP does not vary greatly with chronological age or overall level of cognitive ability for individuals with Williams syndrome. Possible applications for the WSCP include psychoeducational evaluation and empirical research such as the search for genotype/phenotype relations in this genetically based syndrome.     

Tool use in neurodegenerative diseases: Planning or technical reasoning?

Recent works showed that tool use can be impaired in stroke patients because of either planning or technical reasoning deficits, but these two hypotheses have not yet been compared in the field of neurodegenerative diseases. The aim of this study was to address the relationships between real tool use, mechanical problem‐solving, and planning skills in patients with Alzheimer's disease (AD, n = 32), semantic dementia (SD, n = 16), and corticobasal syndrome (CBS, n = 9). Patients were asked to select and use ten common tools, to solve three mechanical problems, and to complete the Tower of London test. Motor function and episodic memory were controlled using the Purdue Pegboard Test and the BEC96 questionnaire, respectively. A data‐transformation method was applied to avoid ceiling effects, and single‐case analysis was performed based on raw scores and completion time. All groups demonstrated either impaired or slowed tool use. Planning deficits were found only in the AD group. Mechanical problem‐solving deficits were observed only in the AD and CBS groups. Performance in the Tower of London test was the best predictor of tool use skills in the AD group, suggesting these patients had general rather than mechanical problem‐solving deficits. Episodic memory seemed to play little role in performance. Motor dysfunction tended to be associated with tool use skills in CBS patients, while tool use disorders are interpreted as a consequence of the semantic loss in SD in line with previous works. These findings may encourage caregivers to set up disease‐centred interventions.     

A family of Gödel hybrid logics

In this paper, we define a family of fuzzy hybrid logics that are based on Gödel logic. It is composed of two infinite-valued versions called ${\mathsf{GH}}_{\infty }$ and ${\mathsf{WGH}}_{\infty }$, and a sequence of finitary valued versions ${({\mathsf{GH}}_n)}_{0<n<\infty }$. We define decision procedures for both ${\mathsf{WGH}}_{\infty }$ and ${({\mathsf{GH}}_n)}_{0<n<\infty }$ that are based on particular sequents and on a set of proof rules dealing with such sequents. As these rules are strongly invertible the procedures naturally allow one to generate countermodels. Therefore we prove the decidability and the finite model property for these logics. Finally, from the decision procedure of ${\mathsf{WGH}}_{\infty }$, we design a sound and complete sequent calculus for this logic.     

“If You Can’t Follow,You’re Out.” The Perspectives of People with Mental Health Problems on Citizenship

Applied Research in Quality of Life - The new paradigm of ‘community care’ promotes the integration of people with mental health problems in society. This reconversion in social care...