Minorities and the Philosophical Marketplace

This article argues for two theses. The first is that many of the sociological factors endemic in the philosophical community function as barriers to the recruitment of members of minority groups in the profession and to their functioning as public intellectuals. The division into familial groups, the fights for security and success, and the weakness of the federal organization of the American Philosophical Association all contribute to these barriers. The second is that sociology has a place in philosophy, even though it should not be confused with it. This means that philosophers need to consider social phenomena.     

Accounting for HIV Risk Among Men on Methadone

This study explores accounts and reasons for engaging in HIV risk-taking behaviors reported by heterosexual men in methadone treatment programs in the Harlem section of New York City. A convenience sample of 62 men who reported having abused their female partners in the past 12 months participated in 10 focus groups. Data analysis revealed four types of HIV risky accounts, which we labeled nihilistic, hedonistic, fatalistic, and normative. The accounts were rarely found in isolation, but were delivered in rich “performative” constellations. We conclude that normative accounts in particular have important implications for HIV prevention. They show that the (hetero)sexual act is interactive “hard work” to say the least, and condoms have no role interrupting it. In the end, the risks of losing masculine face before a female partner are very much prioritized over long-run HIV risks.     

Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory

Evidence suggests that plasticity of the amygdalar and hippocampal GABAergic system is critical for fear memory formation. In this study we investigated in wild-type and genetically manipulated mice the role of the activity-dependent 65-kDa isozyme of glutamic acid decarboxylase (GAD65) in the consolidation and generalization of conditioned fear. First, we demonstrate a transient reduction of GAD65 gene expression in the dorsal hippocampus (6 h post training) and in the basolateral complex of the amygdala (24 h post training) during distinct phases of fear memory consolidation. Second, we show that targeted ablation of the GAD65 gene in Gad65(-/-) mice results in a pronounced context-independent, intramodal generalization of auditory fear memory during long-term (24 h or 14 d) but not short-term (30 min) memory retrieval. The temporal specificity of both gene regulation and memory deficits in Gad65 mutant mice suggests that GAD65-mediated GABA synthesis is critical for the consolidation of stimulus-specific fear memory. This function appears to involve a modulation of neural activity patterns in the amygdalo-hippocampal pathway as indicated by a reduction in theta frequency synchronization between the amygdala and hippocampus of Gad65(-/-) mice during the expression of generalized fear memory.     

On the requirement of nitric oxide signaling in the amygdala for consolidation of inhibitory avoidance memory

Evidence suggests that the NO/sGC/PKG pathway plays a key role in memory processing but the actual participation of this signaling cascade in the amygdala during memory consolidation remains unknown. Here, we show that when infused in the amygdala immediately after inhibitory avoidance training, but not later, the NO synthase inhibitor L-NNA hindered long-term memory retention without affecting locomotion, exploratory behavior, anxiety state or retrieval of the avoidance response. The amnesic effect of L-NNA was not state-dependent and was mimicked by the soluble guanylyl cyclase inhibitor LY83583 and the PKG inhibitor KT-5823. On the contrary, post-training intra-amygdala infusion of the NOS substrate L-Arg, the NO-releasing compound SNAP or the non-hydrolysable analog of cGMP 8Br-cGMP increased memory retention in a dose-dependent manner. Co-infusion of 8Br-cGMP reversed the amnesic effect of L-NNA and LY83583 but not that of KT-5823. Our data indicate that the NO-induced activation of PKG in the amygdala is a necessary step for consolidation of inhibitory avoidance memory.     

Categories and Levels of Reality

The discussion of the relation of levels of reality to categories is important because categories have often been interpreted as constituting levels of reality. This article explores whether this view is correct, and argues it is not. Categories as such should not be understood to constitute levels of reality, although particular categories may. The article begins with a discussion of levels of reality and then turns to specific questions about categories and how they are related to these levels.     

BOLD activation varies parametrically with corner angle throughout human retinotopic cortex

The Alternating Brightness Star (ABS) is an illusion that provides insight into the relationship between brightness perception and corner angle. Recent psychophysical studies of this illusion have shown that corner salience varies parametrically with corner angle, with sharp angles leading to strong illusory percepts and shallow angles leading to weak percepts. It is hypothesized that the illusory effects arise because of an interaction between surface corners and the shape of visual receptive fields: sharp surface corners may create hotspots of high local contrast due to processing by center-surround and other early receptive fields. If this hypothesis is correct, early visual neurons should respond powerfully to sharp corners and curved portions of surface edges. Indeed, the primary role of early visual neurons may be to localize the discontinuities along the edges of surfaces. If so, all early visual areas should show greater BOLD responses to sharp corners than to shallow corners. On the other hand, if corner processing is exclusively constrained to certain areas of the brain, only those specific areas will show greater responses to sharp vs shallow corners. To address this we explored the BOLD correlates of the ABS illusion in the human visual cortex using fMRI. We found that BOLD signal varies parametrically with corner angle throughout the visual cortex, offering the first neurophysiological correlates of the ABS illusion. This finding provides a neurophysiological basis for the previously reported psychophysical data that showed that corner salience varied parametrically with corner angle. We propose that all early visual areas localize discontinuities along the edges of surfaces, and that specific cortical corner-processing circuits further establish the specific nature of those discontinuities, such as their orientation.     

Statutory reform is associated with improved court practice: results of a tri-state comparison

PURPOSE: This study investigates the impact of statutory reform in adult guardianship on court practice. METHODS: Case files for 298 cases of adult guardianship were reviewed in three states with varying degrees of statutory reform: MA (no reform), PA (major amendments in 1992), and CO (full re-enactment of statute per UGPPA in 2000). Five court practices associated with progressive statutory reform were studied: (1) diversion to less restrictive alternatives; (2) minimal and appropriate use of emergency procedures; (3) presence of the alleged incapacitated person at the hearing; (4) use of functional evaluation; (5) use of limited orders. RESULTS: CO more frequently utilized all five practices, whereas PA used diversion to less restrictive alternatives and less frequent emergency procedures, but not other practices. MA files rarely showed evidence for use of any of these reforms. IMPLICATIONS: Statutory reform may improve court practice. More study of the effects of reform on court practices, and the vulnerable adults served by these courts, is needed.     

Are indigenous personality dimensions culture-specific? Mexican inventories and the Five-Factor Model

The universality versus cultural specificity of Mexican personality dimensions was investigated by examining: (a) the replicability of Mexican personality dimensions assessed by indigenous inventories; and (b) the extent to which Mexican dimensions are encompassed by the Five-Factor Model (FFM), one hypothesized universal model of personality structure. Mexican university students (N = 794) completed nine indigenous inventories and the Spanish version of the Revised NEO Personality Inventory. The FFM replicated well, although reliability was poor for a few facet scales. Reliability was acceptable for the indigenous Mexican scales. However, for most indigenous instruments, a cross-sample replication criterion suggested alternative structures of fewer, more replicable dimensions. Multiple regression and joint factor analyses revealed that most of the Mexican dimensions were well subsumed by the FFM. Thus, cultural differences did not involve clearly culture-specific dimensions, but more subtle differences in the salience or cultural flavor of particular traits.     

Rorschach Comprehensive System data for a sample of 357 Portuguese children at five ages

Eighteen examiners, well trained in the Comprehensive System (CS; Exner, 2003), administered the Rorschach to 357 Portuguese children, in the first through fifth grades, attending schools located in Lisbon and the surrounding neighborhood. Coding was done by 5 of the examiners, each one having more than 5 years of experience with the CS. For this study, coding was reviewed by the authors. Five records were randomly selected from each age group to assess intercoder reliability. Janson and Olsson's (2004) iota was used to assess reliability of the main variable categories. Results are high, with iota ranging from 0.87 to 0.98 across the coding categories. CS variables are presented and key data were chosen and reviewed. A discussion of some data and their comparison with corresponding American data are made, permitting some interesting developmental and cross-cultural questions to be addressed.