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61.
Differential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks 总被引:3,自引:0,他引:3
Teather LA Packard MG Smith DE Ellis-Behnke RG Bazan NG 《Neurobiology of learning and memory》2005,84(2):75-84
Research examining the neuroanatomical bases of memory in mammals suggests that the hippocampus and dorsal striatum are parts of independent memory systems that mediate "cognitive" and stimulus-response "habit" memory, respectively. At the molecular level, increasing evidence indicates a role for immediate early gene (IEG) expression in memory formation. The present experiment examined whether acquisition of cognitive and habit memory result in differential patterns of IEG protein product expression in these two brain structures. Adult male Long-Evans rats were trained in either a hippocampal-dependent spatial water maze task, or a dorsal striatal-dependent cued water maze task. Ninety minutes after task acquisition, brains were removed and processed for immunocytochemical procedures, and the number of cells expressing Fos-like immunoreactivity (Fos-like-IR) and c-Jun-IR in sections from the dorsal hippocampus and the dorsal striatum were counted. In the dorsal hippocampus of rats trained in the spatial task, there were significantly more c-Jun-IR pyramidal cells in the CA1 and CA3 regions, relative to rats that had acquired the cued task, yoked controls (free-swim), or na?ve (home cage) rats. Relative to rats receiving cued task training and control conditions, increases in Fos-like IR were also observed in the CA1 region of rats trained in the spatial task. In rats that had acquired the cued task, patches of c-Jun-IR were observed in the posteroventral striatum; no such patches were evident in rats trained in the spatial task, yoked-control rats, or na?ve rats. The results demonstrate that IEG protein product expression is up-regulated in a task-dependent and brain structure-specific manner shortly after acquisition of cognitive and habit memory tasks. 相似文献
62.
The human ability to detect symmetry has been a topic of interest to psychologists and philosophers since the 19th century, yet surprisingly little is known about the neural basis of symmetry perception. In a recent fMRI study, Sasaki and colleagues begin to remedy this situation. By identifying the neural structures that respond to symmetry in both humans and macaques, the authors lay the groundwork for understanding the neural mechanisms underlying symmetry perception. 相似文献
63.
According to the perceptual symbols theory (Barsalou, 1999), sensorimotor simulations underlie the representation of concepts.
Simulations are componential in the sense that they vary with the context in which the concept is presented. In the present
study, we investigated whether representations are affected by recent experiences with a concept. Concept names (e.g., APPLE)
were presented twice in a property verification task with a different property on each occasion. The two properties were either
from the same perceptual modality (e.g.,green, shiny) or from different modalities (e.g.,tart, shiny). All stimuli were words. There was a lag of several intervening trials between the first and second presentation. Verification
times and error rates for the second presentation of the concept were higher if the properties were from different modalities
than if they were from the same modality. 相似文献
64.
Hale LR Goldstein DS Abramowitz CS Calamari JE Kosson DS 《Behaviour research and therapy》2004,42(6):697-710
Although the hypothesis that psychopathic individuals are characterized by a reduced capacity for experiencing anxiety is central to many theories of psychopathy, most prior studies have examined anxiety and fear measures generally considered outdated in the literature. Moreover, prior findings are mixed, with several studies reporting no relationships between psychopathy and anxiety, and others suggesting negative relationships for the affective, interpersonal aspects of the disorder and positive relationships for the antisocial behavior dimension. To examine whether psychopathy dimensions are associated with contemporary measures of anxiety, the Anxiety Sensitivity Index and State Trait Anxiety Inventory-Trait scale were administered to 157 male inmates. Participants also completed the MMPI-derived Welsh Anxiety Scale (WAS), commonly used in psychopathy studies. Analyses provide no evidence for a negative relationship between psychopathy's affective, interpersonal factor and anxiety sensitivity after controlling for trait anxiety. Trait anxiety and WAS scores were positively associated with the antisocial behavior dimension of psychopathy. Findings do replicate prior relationships between the WAS and psychopathy, suggesting the WAS may measure aspects of negative affectivity that differ from anxiety. 相似文献
65.
We conducted an analysis of precurrent skills (responses that increase the effectiveness of a subsequent or "current" behavior in obtaining a reinforcer) to facilitate the solution of arithmetic word (story) problems. Two students with developmental disabilities were taught four precurrent responses (identifying the initial value, change value, operation, and resulting value) in a sequential manner. Results of a multiple baseline design across behaviors showed that the teaching procedures were effective in increasing correct performance of each of the precurrent behaviors with untaught problems during probes and that once the precurrent behaviors were established, the number of correct problem solutions increased. 相似文献
66.
A new self-report scale, the Altruism Scale for Adults, of 28 items was developed. 14 items were from the Altruism subscale of Wrightsman's Philosophies of Human Nature Scale, and the other 14 items were newly constructed. The scale, anchored by 1: true or 2: false, was administered to 592 Korean men and women in eight subgroups. Cronbach alpha internal consistency was .89, and test-retest reliabilities (n = 52) over 1 and 5 wk. were .90 and .80, respectively. Campbell and Fiske's 1959 multitrait-multimethod analysis showed satisfactory convergent and discriminant validities. Overall results were promising for use of the scale in research and for practical purposes. 相似文献
67.
Recent studies suggest that research participants show reduced distortion of their taboo attitudes and behaviors when they take part in Internet-based procedures from outside the laboratory. We explored whether such procedures would reduce distortion in the assessment of racial bias. In Study 1, White participants who completed the study in the laboratory evaluated Black targets more favorably than White targets. This unexpected "outgroup-favoring" pattern occurred in both pencil-and-paper and Internet versions of the study, showing that modality did not produce it; but when participants worked outside the laboratory via the Internet, this pattern disappeared. Study 2 replicated the above findings and further indicated that the reduced distortion in Internet-based studies was due to the removal of the experimenter rather than removing the participants from the laboratory environment. The implications of these findings for the study of controlled processes of prejudice and the nature of Internet-based social communication are discussed. 相似文献
68.
Effects of experience on fetal voice recognition 总被引:1,自引:0,他引:1
Kisilevsky BS Hains SM Lee K Xie X Huang H Ye HH Zhang K Wang Z 《Psychological science》2003,14(3):220-224
Abstract - The ability of human fetuses to recognize their own mother's voice was examined. Sixty term fetuses were assigned to one of two conditions during which they were exposed to a tape recording of their mother or a female stranger reading a passage. Voice stimuli were delivered through a loudspeaker held approximately 10 cm above the maternal abdomen and played at an average of 95 dB SPL. Each condition consisted of three 2-min periods: no stimulus, voice (mother or stranger), and no stimulus. Fetal heart rate increased in response to the mother's voice and decreased in response to the stranger's; both responses were sustained for 4 min. The finding of differential behavior in response to a familiar versus a novel voice provides evidence that experience influences fetal voice processing. It supports an epigenetic model of speech perception, presuming an interaction between genetic expression of neural development and species-specific experience. 相似文献
69.
Kang SY Lee KY Park MJ Kim YC Markelonis GJ Oh TH Kim YC 《Neurobiology of learning and memory》2003,79(1):11-18
We previously reported that a total methanolic extract of the underground part of Angelica gigas Nakai (Umbelliferae) (here-in-after abbreviated AG) significantly inhibited acetylcholinesterase (AChE) activity. We characterized 12 coumarin derivatives including both decursin and decursinol from extracts of AG. In this study, we evaluated the anti-amnestic activity of decursin, a major coumarin constituent isolated from AG, in vivo using ICR mice with amnesia induced by scopolamine (1 mg/kg body weight, s.c.). Decursin, when administered to mice at 1 and 5 mg/kg body weight i.p., significantly ameliorated scopolamine-induced amnesia as measured in both the passive avoidance test and the Morris water maze test. Moreover, decursin significantly inhibited AChE activity by 34% in the hippocampus of treated mice. These results indicate that decursin may exert anti-amnestic activity in vivo through inhibition of AChE activity in the hippocampus. 相似文献
70.