Pharmacological dissociation of memory: anisomycin, a protein synthesis inhibitor, and leupeptin, a protease inhibitor, block different learning tasks

Inhibition of protein synthesis by anisomycin for a short duration impairs memory of a one-trial inhibitory avoidance task in rats. Memory of escape conditioning involving eight trials is disrupted only if the duration of protein synthesis is prolonged by repeated injections. In marked contrast, olfactory memory of rats trained on two odor discriminations is not affected by anisomycin even if the duration of inhibition is prolonged and the number of trials is reduced to a minimum. In previous work, leupeptin, a thiol proteinase inhibitor, was shown to impair olfactory discrimination learning, but left inhibitory and avoidance conditioning intact. Together, these results provide a pharmacological double dissociation of memory, and suggest that the same chemistries, or mixtures of chemistries, may not be involved in all types of memory.     

Exploration and avoidance in rats with lesions in amygdala and piriform cortex

Lesions localized to specific areas of the amygdala and overlying cortex in rats produced differential effects in several behavioral tasks. Three different types of lesions were tested: central, basolateral, and cortex lateral to the amygdala. Lesions restricted to the central nucleus produced increased activity on all parameters studied in an open-field test, but the other two groups were not changed. In one-way active avoidance all three groups with lesions showed deficits. The most pronounced change was observed in the central group. All groups showed the same degree of retention loss, but in forced extinction of one-way active avoidance after retraining, the cortical and basolateral groups were most defective. A fear-reduction hypothesis is proposed for the central lesion. The basolateral and cortical areas may be more specifically involved in passive avoidance behavior.     

Differential indications for desipramine--results of a controlled multiclinical study]

The antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective symptoms, which was not detectable for the inhibition of drive. The tachythymoleptic action of desipramine is discussed with reference to these results. Evaluation of the possibility of controlling affects shows different ranges of activity of desipramine and imipramine, with desipramine influencing especially negative psychoenergetic symptoms in the area of drives and emotions and imipramine, restrictive symptoms in addition to differential phenomena of the psychomotor expression.     

Why child neuropsychiatry?]

The author gives a brief survey of the development of Child-Neuropsychiatry in the G.D.R. and subsequently gives reasons for the decision in favor of the unity of neurology and psychiatry as applied to children and juveniles, which is in contrast to developments in other countries. In addition to hygienic, economic, organizational, and medical considerations, this decision was also determined by the fact that a Child-Neuropsychiatrist must, in his practical work as a subspecialist, be able to head a multiprofessional team and, thus, help assure optimum development of a child's personality.     

Prediction as a means of inducing tolerance

Female subjects were exposed individually to the attitude item responses of a similar or dissimilar stranger. They were asked either to copy down the stranger's attitudes or to predict (with accurate feedback) how the stranger answered each item. Predict subjects were found to be more tolerant of the dissimilar stranger than were Copy subjects, while both groups were equally attracted to the similar stranger. It was suggested that training people to anticipate disagreements may be a useful way of fostering tolerance.     

Women in Technology: A Program to Increase Career Awareness

Most women work to help support themselves and their families. Unfortunately young women are not often encouraged to explore occupational options that offer increased economic mobility. This article describes a program designed to develop awareness of nontraditional technical careers for women, careers that require less than four years of postsecondary education. Attended by guidance counselors and math and science teachers, the conference explored the psychological implications of nontraditional choices as well as provided information about these occupations. The article also discusses funding, program development and design, and evaluation.     

The air gap phenomenon in children's landscape drawings

The “air gap” phenomenon was found to be very common in the free landscape drawings of middle and later childhood. Three experiments are reported in which the contextual cues for such drawings were systematically manipulated. When subjects were supplied with drawing sheets constructed to imply the absence of the air gap, the phenomenon was eliminated in most of their drawings. When supplied with sheets constructed to imply its presence, most subjects produced air gap drawings using contextually provided reference lines. There were no consistent transfer effects across different cuing orders. The susceptibility of the air gap phenomenon to modification by task manipulation suggests that it results from problems of production rather than from defects in the child's internal representation of the world.     

Negative attitudes toward masturbation and pelvic vasocongestion: A thermographic analysis

The present study examined differences in pelvic vasocongestion as a function of negative attitudes toward masturbation. Pelvic vasocongestion was measured thermographically, which is a noninvasive means of detecting and photographing individual heat patterns to indicate physiological condition and functional changes within. The results indicated that women, with positive attitudes toward masturbation, who read an erotic story, experienced the greatest increase in pelvic vasocongestion. This and other findings were discussed in terms of masturbation acting to facilitate the patterning of sexual arousal and orgasmic functioning, especially in regard to creating the capacity for pelvic engorgement.