Systemic administration of a nitric oxide synthase inhibitor impairs fear sensitization in the plus-maze

The aim of the present study was to evaluate the occurrence of fear sensitization in rats previously treated with an inhibitor of the NO syntheses and submitted to Trial1/Trial2 plus-maze (PM) procedure. Male Wistar rats received a systemic treatment with N(omega)-nitro-L-Arginine-methyl ester (L-NAME; 5, 10 or 50 mg kg(-1)) and were submitted to PM Trial1. In the following day the animals were re-exposed to the PM with no drug administration (Trial2). Some standards spatial-temporal measures, such as the percentage of entries (% Open arm entries) and time spent (% Open arm time) in the open arms and risk assessment frequency were recorded and used to estimate the animal level of fear sensitization in PM Trial2. The results showed that animals receiving L-NAME (50 mg kg(-1)) displayed increased % Open arm entries and % Open arm time in Trial2 in relation to the group receiving 0.9% saline, which is compatible with impaired fear/anxiety acquisition during Trial1/Trial2 PM procedure. In addition, rats treated with L-NAME (50 mg kg(-1)) exhibited low level of risk assessment in Trial2 in relation to the group treated with 0.9% saline, which indicates low level of fear/anxiety during PM re-exposure. The number of entries into the enclosed arms was not changed by any L-NAME treatment, which suggests no bias of the drug treatments on animal locomotor activity. The data suggest that NO synthesis may mediate the fear sensitization process in the PM.     

The effects of task-irrelevant threatening stimuli on orienting- and executive attentional processes under cognitive load

Human visual attention is biased to rapidly detect threats in the environment so that our nervous system can initiate quick reactions. The processes underlying threat detection (and how they operate under cognitive load), however, are still poorly understood. Thus, we sought to test the impact of task-irrelevant threatening stimuli on the salience network and executive control of attention during low and high cognitive load. Participants were exposed to neutral or threatening pictures (with moderate and high arousal levels) as task-irrelevant distractors in near (parafoveal) and far (peripheral) positions while searching for numbers in ascending order in a matrix array. We measured reaction times and recorded eye-movements. Our results showed that task-irrelevant distractors primarily influenced behavioural measures during high cognitive load. The distracting effect of threatening images with moderate arousal level slowed reaction times for finding the first number. However, this slowing was offset by high arousal threatening stimuli, leading to overall shorter search times. Eye-tracking measures showed that participants fixated threatening pictures more later and for shorter durations compared to neutral images. Together, our results indicate a complex relationship between threats and attention that results not in a unitary bias but in a sequence of effects that unfold over time.     

Die verwundbare Analytikerin

The withdrawal of acceptance lies at the centre of the traumatic experience and the disastrous consequences are overwhelming feelings of anxiety and shame relating to the individual’s own existence. Intense feelings in traumatised individuals are accompanied by fundamental shame as they fear once again being inundated by their own emotions and thus yet again becoming helpless and defenceless. Further, the emergence of emotions inevitably demonstrates their roots in the individual personality and it is precisely the withdrawal of recognition as a separate, autonomous being which these individuals have experienced. “When I experience myself as an individual with feelings, then I am but I am not allowed to be” seems to be what these people are unconsciously thinking. Recognition, in the true sense of the word, can only be achieved by the performative act of recognition both of the subjectivity and of the trauma. Such acts of recognition can be performed in the psychoanalytical process when the analyst shows herself as being involuntarily vulnerable and at the same time as a survivor of that vulnerability. This means, however, that the dialectic tension must not only be endured but under certain circumstances also admitted; the tension between the wish to keep all emotions within oneself and the simultaneous unavoidable failure to do so. Only an analyst who is actively alive can, in the last resort, help the traumatised to establish contact with the world of living objects and to feel themselves as being alive.     

A Cognitive Psychophysiological Model to Predict Functional Decline in Chronically Stressed Older Adults

The current study evaluated whether psychological distress (composite of depression, anxiety, vital exhaustion), inflammation (C-reactive protein, CRP) and cognitive function (Digit Symbol Test, DST) and their changes mediated the relationship between caregiver status and functional decline. Caregivers for spouses with Alzheimer’s disease were compared to demographically-similar non-caregiver spouses at study entry (T1), T2 (1 year later), and T3 (2 years after T1). Caregivers had greater functional impairment, higher distress scores, and poorer DST scores at all points of measurement and also showed functional decline. Non-caregivers did not demonstrate functional decline. Caregivers declined 85% faster than did non-caregivers. Regressions showed that after controlling for functional impairment at T1, illness, medication, and health behavior covariates, psychological distress at T1 and increases in CRP from T1 to T3 mediated the difference in functional decline. Moreover, after DST decline from T1 to T2 was entered in the model, caregiver status, psychological distress and increases in inflammation all showed reductions in their predictive importance. These findings suggest psychological distress and increases in inflammation may help explain why caregivers show greater functional decline than non-caregivers. However, the influences of these psychophysiological variables may be driven in part by cognitive decline prior to functional decline. This article is based upon an invited address, “Potential Hazards of Caring for a Loved One with Alzheimer’s Disease” given by the first author in recognition of the author’s receipt of the Association of Psychologists in Academic Health Centers 2005 Award for Distinguished Achievement in Research. The address was presented at the Annual meeting of the American Psychological Association, New Orleans, LA., August, 2006.     

Self-report measures of child and adolescent psychopathy as predictors of offending in four samples of justice-involved youth

The authors examined the relation between self-report psychopathy measures and official records of offending in four samples of justice-involved youth (total N = 447). Psychopathy measures included the Antisocial Process Screening Device (APSD) and a modified version of the Childhood Psychopathy Scale (mCPS). Measures of offending included the total number of preadmission arrest charges for three samples (n = 392) and the total number of offenses in the year following release for two samples (n = 138). Neither measure was a strong correlate of preadmission offenses. Although mCPS scores were associated with postrelease offending in one sample, effects for the APSD were observed only when reoffending was conceptualized as a dichotomous variable, indicating a lack of robustness in this association. The findings suggest caution in the use of self-report measures of psychopathic features for decision making with respect to issues of delinquency risk among justice-involved youth.     

Differential effects of age on prospective and retrospective memory tasks in young, young-old, and old-old adults

Remembering to do something in the future (termed prospective memory) is distinguished from remembering information from the past (retrospective memory). Because prospective memory requires strong self-initiation, Craik (1986) predicted that age decrements should be larger in prospective than retrospective memory tasks. The aim of the present study was to assess Craik's prediction by examining the onset of age decline in two retrospective and three prospective memory tasks in the samples of young (18-30 years), young-old (61-70 years), and old-old (71-80 years) participants recruited from the local community. Results showed that although the magnitude of age effects varied across the laboratory prospective memory tasks, they were smaller than age effects in a simple three-item free recall task. Moreover, while reliable age decrements in both retrospective memory tasks of recognition and free recall were already present in the young-old group, in laboratory tasks of prospective memory they were mostly present in the old-old group only. In addition, older participants were more likely to report a retrospective than prospective memory failure as their most recent memory lapse, while the opposite pattern was present in young participants. Taken together, these findings highlight the theoretical importance of distinguishing effects of ageing on prospective and retrospective memory, and support and extend the results of a recent meta-analysis by Henry, MacLeod, Phillips, and Crawford (2004).     

Examining the Relations Among Narcissism, Impulsivity, and Self-Defeating Behaviors

ABSTRACT A recent meta-analysis ( S. Vazire & D. C. Funder, 2006 ) suggested that narcissism and impulsivity are related and that impulsivity partially accounts for the relation between narcissism and self-defeating behaviors (SDB). This research examines these hypotheses in two studies and tests a competing hypothesis that Extraversion and Agreeableness account for this relation. In Study 1 , we examined the relations among narcissism, impulsivity, and aggression. Both narcissism and impulsivity predicted aggression, but impulsivity did not mediate the narcissism–aggression relation. In Study 2 , narcissism was related to a measure of SDB and manifested divergent relations with a range of impulsivity traits from three measures. None of the impulsivity models accounted for the narcissism–SDB relation, although there were unique mediating paths for traits related to sensation and fun seeking. The domains of Extraversion and low Agreeableness successfully mediated the entire narcissism–SDB relation. We address the discrepancy between the current and meta-analytic findings.     

Implicit Hopelessness and Condom Use Frequency: Exploring Nonconscious Predictors of Sexual Risk Behavior1

Current models of affect and health posit that affective disturbance influences health through behavioral pathways. The current research explores this hypothesis in the domain of sexual risk behavior by testing explicit and implicit hopelessness as predictors of condom use. Male and female undergraduates (n = 60) completed implicit and explicit measures of depression, hopelessness, and self‐reported condom use frequency. Findings revealed that implicit hopelessness predicted less condom use. However, this relationship was moderated by gender such that implicit hopelessness predicted less condom use for men, but not for women. The applicability of the findings to broader health theories is discussed.