The Effect of Selective Serotonin Releasing Agents in the Chronic Mild Stress Model of Depression in Rats

Chronic exposure to mild unpredictable stress has been found to depress the consumption of, and preference for, highly palatable sucrose solution in rats. Stress-induced behavioral deficits may be maintained for a long time, however chronic administration of clinically effective antidepressants can restore normal behavior. This is the first report showing that Sprague-Dawley rats can be used in this model. A preference deficit in this strain of rats took at least 7 weeks to develop; about twice the time required when hooded Lister or Wistar rats are used in this model. Water consumption was not effected by chronic exposure to the mild stress regime and/or by chronic administration of the selective serotonin (5-HT) releasing agent MMAI (5-methoxy-6-methyl-2-aminoindan). The stress-induced deficit in sucrose intake was completely reversed by chronic treatment with MMAI (5 mg/kg, 2 x day) over 3 weeks in the two-bottle tests. In single-bottle tests, chronic treatment with the selective 5-HT releasers, MMAI (5 mg/kg, 2 x day) or MTA (p-methylthioamphetamine; 5 mg/kg, 2 x day), reversed the deficit in rewarded behavior (anhedonia) measured as a decrease in the consumption of 1% sucrose solution in the chronic mild stress model of depression in rats. With the experimental procedure employed, and at a dose of 10 mg/kg/day of 5-HT releasers, the magnitude and onset of this effect were greater than observed following similar administration of the selective 5-HT reuptake inhibitor (SSRI) sertraline (10 mg/kg/day), used as a standard anti-depressant drug.     

DEVELOPMENT OF MULTIPLE JOB PERFORMANCE MEASURES IN A REPRESENTATIVE SAMPLE OF JOBS

The goal of criterion development in Project A was to construct multiple measures of the major components of job performance such that the total performance domain for a representative sample of the population of entry-level enlisted positions in the U.S. Army was covered. These measures were to be used as criteria against which to validate both experimental and existing predictors of job performance. The initial model specified that performance is multidimensional within two major categories of dimensions designated as organization-wide and job specific. The development strategy involved describing the total domain of job content via extensive task analyses and critical incident analyses, generating the critical performance dimensions that constitute it, constructing measures for each dimension, and evaluating each measure using expert judgment and field test data. The specific measures developed consisted of rating scales, tests of job knowledge, hands-on job samples, and archival records. The major steps in the job analyses, content sampling, instrument construction, and instrument evaluation are described, and the final array of criterion measures is presented.     

Characteristics of on Organizational Environment which Stimulate and Inhibit Creativity*

The study investigated the characteristics of Brazilian organizations which affect creativity. A sample of 25 workers were interviewed. The respondents answered several questions about the characteristics of a work environment which promote and inhibit creativity, and about factors in their own work environment that contribute to the promotion or inhibition of creativity. Content analysis of the transcribed interviews indicated 10 categories of stimulants and 11 categories of obstacles to creativity. Among the most mentioned stimulant factors to creativity were organization support, organization structure, support from the boss, and colleagues' support. On the other hand, some of the most prevalent obstacles to creativity were organization structure, boss characteristics, personal relationships, and organization culture. Results are discussed in terms of the similarity with data obtained in other contexts.     

INTRODUCTION: GLOBAL DEMOCRACY AND EXCLUSION

Abstract: Does democracy or popular sovereignty imply exclusion and drawing borders? And if so, what type of exclusion and borders, and what kind of justification can we give for them? Moreover, if democracy really requires some kind of exclusion, is global democracy then a paradoxical union of two contradictory ideals? Can we create a demos on the global level? The focus of this collection of essays is on this potential conflict and its underlying values.     

NON-DISCURSIVE EXPRESSIVE ELEMENTS AND THEIR ROLE IN THE CONSTRUCTION OF MEANING IN THE ANALYTICAL SITUATION

The author discusses the role of non‐discursive expressive elements in the construction of the analytical situation, using three examples to illustrate the problems with which he is concerned. His claim is that the issue in question necessarily involves the subject of affects, and he proceeds to discuss the difficulties associated with this subject. In addition, he considers the contributions of Green and Imbasciati, and Kleinian developments of this theme, including also the contributions of Bion—in particular the latter's theories concerning thought, in which emotion comes to assume an essential place in the origin of thinking. The author resumes the discussion by taking up his clinical examples, using them to put forward the view that non‐discursive expressive elements may well play a decisive role in the construction of meaning in the analytical situation. He suggests also that the meaning of an emotional experience may be thought of as a construction contributed to by a number of symbolic forms which both interfere with and interact with the symbolic system of language. Following examination of his third example, the author reflects on ‘musicality’, a notion sometimes referred to informally in clinical data in connection with the ‘emotional climate’ of the session. He proposes that the complex problem of meaning in music be extended to cover the construction of meaning in the psychoanalytic setting, and in so doing returns to ideas put forward by Suzanne Langer. His underlying view here is that essential elements of the musical phenomenon and essential elements of particular forms of emotional life give rise to the same emotional matrices—perhaps to what Meltzer calls ‘musical deep grammar’. Finally, the author considers various symbolic forms that contribute to the particular configuration of analytical situations, suggesting that the mental condition of ‘free‐floating attention’ requires the broad availability to the analyst's mind of a multiplicity of symbolic forms, his conversion of these into new expressions of meaning, and the possibility of their verbal communication by him to the patient.