Human d-amphetamine drug discrimination: methamphetamine and hydromorphone.

Standard measures of subjective and discriminative effects of drugs were compared in 5 human volunteers. Subjects responded on a second-order color-tracking procedure, where 30 mg of d-amphetamine served as a discriminative stimulus for one response and its absence as the discriminative stimulus for another response. Self-reported subjective effects were assessed concurrently using the single-dose questionnaire, subscales of the Addiction Research Center Inventory, and several analogue rating scales. On different days following discrimination acquisition, varying doses of d-amphetamine, methamphetamine, and hydromorphone were administered. In these test sessions, either response was reinforced. Methamphetamine and d-amphetamine occasioned dose-related increases in d-amphetamine appropriate responding; hydromorphone did not. Methamphetamine and d-amphetamine occasioned dose-related increases in reports of the drug received being most like "speed"; hydromorphone occasioned dose-related increases in reports of the drug received being most like "dope." All three drugs occasioned dose-related increases in reports of drug liking, and increases in the morphine-benzedrine group, amphetamine, and benzedrine group scales of the Addiction Research Center Inventory. This experiment demonstrated that although explicit discriminative control of behavior by a drug may covary with drug identification, it does not necessarily covary with other self-reported subjective effects. Thus, the complementary nature of the data provided by drug discrimination and standard subjective-effects measures provides quantitative and qualitative data useful in studying both relatively novel compounds and the behavioral biology of psychoactive drugs in general.     

Spectral and pattern response in the rabbit retina.

The advantages of presenting sensory data in terms of stimulus variables are stressed. Spectral sensitivity plots of local electroretinograms and ganglion cell discharges from the dark-adapted rabbit retina illustrate the utility of using this kind of procedure. Spectral data agreed with the literature demonstrating two cone and one rod process in this animal. The spectral sensitivities of both the local electroretinogram and ganglion cell spikes were closely similar. Data pertaining to pattern vision may also be subjected to the same type of analysis and described in terms of stimulus variables.     

Behavioral and pharmacological modulation of respiration in rhesus monkeys.

Changes in respiration associated with schedule-controlled behavior were determined in seated rhesus monkeys prepared with a pressure-displacement head plethysmograph for monitoring ventilation continuously during behavioral experiments. Subjects were trained to press a lever under fixed-ratio 40 and fixed-interval 300-s schedules of stimulus termination. Episodic increases in ventilation were closely associated with periods of responding under both schedules. Recurring episodes of increased ventilation occurred during fixed-ratio responding, and were separated by brief 10-s timeouts during which ventilation decreased. Under the fixed-interval schedule, both ventilation and response rate typically increased as the 300-s interval elapsed. The effects of cocaine, caffeine, and two adenosine agonists, 5'-N-ethylcarboxamidadenosine (NECA) and 2-(carboxyethylphenylamino)adenosine-5'-carboxamide (CGS 21680), on behavior and respiration were determined using a cumulative-dosing procedure. Drug-induced suppression of behavior eliminated the episodic increases in ventilation during the performance components of both schedules. Schedule-related increases in ventilation were compared to those produced by elevated levels of CO2 in inspired air. Exposure to 4% CO2 mixed in air increased ventilation in all subjects, and the combined effects of CO2 exposure and schedule-controlled responding on respiration appeared to be additive. The results suggest that behavioral activities may increase ventilation through increased metabolic demand and increased CO2 production.     

Social reinforcement of operant behavior in rats: a methodological note.

An apparatus was developed to study social reinforcement in the rat. Four Long-Evans female rats were trained to press a lever via shaping, with the reinforcer being access to a castrated male rat. Responding under a fixed-ratio schedule and in extinction was also observed. Social access was found to be an effective reinforcer. When social reinforcement was compared with food reinforcement under similar conditions of deprivation and reinforcer duration, no significant differences were observed.     

Temporal discrimination learning of operant feeding in goldfish (Carassius auratus)

Operant temporal discrimination learning was investigated in goldfish. In the first experiment, there was a fixed daily change in illumination. Eight subjects were trained to operate a lever that reinforced each press with food. The period during which responses were reinforced was then progressively reduced until it was 1 hr in every 24. The final 1-hr feeding schedule was maintained over 4 weeks. The feeding period commenced at the same time each day throughout. The food dispensers were then made inactive, and a period of extinction ensued for 6 days. The pattern of responding suggested that the fish were able to exhibit temporal discrimination in anticipation of feeding time. This pattern of responding persisted for a limited number of days during the extinction procedure. The second experiment produced evidence that operant temporal discrimination could develop under continuous illumination.     

Exchange delays and impulsive choice in adult humans.

Choice responding by adult humans in a discrete-trial task was examined as a function of conditions that manipulated either the delay to point delivery or the delay between points and their exchange for money. In point-delay conditions, subjects chose between an "impulsive" alternative that provided a small amount of points immediately and a "self-control" alternative that provided a larger amount of points delayed by 15, 30, or 60 s. Points were exchanged for money immediately following the session. Subjects preferred the self-control alternative. In exchange-delay conditions, subjects chose between a small amount of points exchangeable for money immediately following the session and a larger amount of points exchangeable for money after 1 day, 3 weeks, or 6 weeks. A self-control preference observed for all subjects in the 1-day exchange-delay condition reversed to exclusive impulsive preference for 4 of the 6 subjects when choice conditions involved exchange delays of 3 or 6 weeks. These results show that human choice is sensitive to the manipulation of exchange delays and that impulsive preference can be obtained with exchange delays on the order of weeks.     

Varying the temporal placement of a drinking opportunity in a fixed-interval schedule.

Three rats, lever pressing for food delivered on a fixed-interval 128-s schedule, were presented with a 16-s opportunity to drink from a retractable water source. The temporal placement of the water probe within the reinforcement cycle was varied sequentially, in steps of 16 s. Although the lever-pressing pattern was modulated by the intercalated water probe, water consumption during the probe itself was a decreasing function of time from the following reinforcer. These results were interpreted as evidence against the notion that schedule-induced drinking is a "ubiquitous" phenomenon and are congruent with results from other "intruded stimulus" experiments.     

Human choice in concurrent ratio-interval schedules of reinforcement.

Seven undergraduates participated in a concurrent-choice experiment with monetary reinforcers. Response-independent analogues of variable-interval and variable-ratio schedules were used to assess whether subjects would maximize reinforcement rate. The optimal pattern of behavior, in terms of maximizing reinforcement rate, involved a large bias toward the ratio alternative, with only occasional sampling of the interval schedule. Most experiments with pigeons, however, demonstrate matching of response rates to reinforcement rates, with only slight biases for the ratio schedule. Although subjects in the present experiment allocated more time to the ratio alternative than required by matching, the magnitude of the bias did not approximate that predicted by a maximizing account. After exposure to clock stimuli correlated with the operation of each schedule, 1 subject's behavior did show a substantial level of bias, increasing the total number of reinforcers obtained, and lay at a point between the predictions of matching and maximizing. The other subjects, however, continued to respond less optimally. The present results can be accounted for by a view of matching that incorporates the effects of delayed reinforcement.     

Valid and more valid? Keys to understanding personal appraisal practices at work

Four empirical studies of the roles of self-report questionnaires, tests, and ratings in employment interviews, staff appraisal, and personnel validation surveys are presented in order to examine the number and relationships of psychological constructs derived from data provided by candidates, employees, and their assessors. Test results are related to different kinds of criteria, including job offers following interview, supervisor ratings on the job, and objective indices of work performance. From the practices reported and observed in these various contexts, a theory of personal appraisal mechanisms in occupational settings is derived using data reduction and linear regression methods. Applications of cognitive information processing theory to self-reports and ratings by individuals, and of exchange theory to the social context of panel discussions among assessors, provide a key to understanding why psychometric measures of personal qualities vary in their power to predict work performance in spite of consistent construct validity.     

Vasopressin, glucose homeostasis, and sucrose taste preferences

Previous research indicates that vasopressin-containing (LE) rats are capable of adapting to the stress of food restriction, whereas vasopressin-deficient (DI) rats cannot adapt to this stressor. It has been postulated that abnormalities in glucose metabolism may be one of the factors leading to the demise of food-restricted DI rats. The present study was conducted to determine if taste preferences are altered in DI animals and if the presentation of exogenous glucose, in the form of sucrose solutions, can ameliorate the effects of the stress of food restriction. Four different concentrations of sucrose solutions were presented to LE and DI rats under the food-restricted condition. In both strains, an 8% sucrose solution was preferred over 0%, 16%, and 32% concentrations, with DI rats consuming more of this concentration than LE rats. Thus, when DI rats had the opportunity of maintaining glucose homeostasis by exogenous supplements, they maintained body weight, displayed no stomach pathology, and survived.