Association of <Emphasis Type="Italic">ADAM10</Emphasis> and <Emphasis Type="Italic">CAMK2A</Emphasis> Polymorphisms with Conduct Disorder: Evidence from Family-Based Studies

Twin and family studies have shown that genetic factors play a role in the development of conduct disorder (CD). The purpose of this study was to identify genetic variants associated with CD using a family-based association study. We used 4,720 single nucleotide polymorphisms (SNPs) from the Illumina Panel and 11,120 SNPs from the Affymetrix 10K GeneChips genotyped in 155 Caucasian nuclear families from Genetic Analysis Workshop (GAW) 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). 20 SNPs had suggestive associations with CD (p < 10⁻³), nine of which were located in known genes, including ADAM10 (rs383902, p = 0.00036) and CAMK2A (rs2053053, p = 0.00098). Our results were verified using the International Multi-Center ADHD Genetics Project (IMAGE) dataset. In conclusion, we identified several loci associated with CD. Especially, the two genes (ADAM10 and CAMK2A) have been reported to be associated with Alzheimer’s disease, bipolar disorder and depression. These findings may serve as a resource for replication in other populations.     

Integration of visual information for saccade production

To foveate a visual target, subjects usually execute a primary hypometric saccade (S1) bringing the target in perifoveal vision, followed by a corrective saccade (S2) or by more than one S2. It is still debated to what extent these S2 are pre-programmed or dependent only on post-saccadic retinal error. To answer this question, we used a visually-triggered saccade task in which target position and target visibility were manipulated. In one-third of the trials, the target was slightly displaced at S1 onset (so-called double step paradigm) and was maintained until the end of S1, until the start of the first S2 or until the end of the trial. Experiments took place in two visual environments: in the dark and in a dimly lit room with a visible random square background. The results showed that S2 were less accurate for shortest target durations. The duration of post-saccadic visual integration thus appears as the main factor responsible for corrective saccade accuracy. We also found that the visual context modulates primary saccade accuracy, especially for the most hypometric subjects. These findings suggest that the saccadic system is sensitive to the visual properties of the environment and uses different strategies to maintain final gaze accuracy.     

Medically Defining,Screening, and Treating Conduct Disorder: A French Controversy

For several decades, the use of psychotropic medication has either been regarded as a medical issue or an example of the medicalization of social problems. As the publication in 2005 of a knowledge synthesis on conduct disorder in children and adolescents and the reply of the «Pas de zéro de conduite» collaboration (literally: No F for Conduct) was a highly important event in the French mental health scene, it deserves a thorough discussion. In the hope of improving the practices and policies targeting children and their families, it is essential to gain a better understanding of the bones of contention between the proponents and opponents of a medical or rather biosocial model. To achieve this, we first analyze how this model assigns a central role to certain disorders defined and diagnosed based on constellations of symptoms. We then identify five dimensions which seem to hold center stage in the controversy: genetic susceptibility, neurocognitive deficits and temperament, the familial and social environment seen as a reservoir of stressors, large-scale screening for disorders using simple instruments and multi-modal treatments, including psychotropic medication. We take an interest in the French debate as this allows us to stand back from the models prevailing in North America. It also underscores the importance of multidisciplinary thinking and social sciences when elaborating clinical or political mental health guidelines.     

Decay uncovered in nonverbal short-term memory

Decay theory posits that memory traces gradually fade away over the passage of time unless they are actively rehearsed. Much recent work exploring verbal short-term memory has challenged this theory, but there does appear to be evidence for trace decay in nonverbal auditory short-term memory. Numerous discrimination studies have reported a performance decline as the interval separating two tones is increased, consistent with a decay process. However, most of this tone comparison research can be explained in other ways, without reference to decay, and these alternative accounts were tested in the present study. In Experiment 1, signals were employed toward the end of extended retention intervals to ensure that listeners were alert to the presence and frequency content of the memoranda. In Experiment 2, a mask stimulus was employed in an attempt to distinguish between a highly detailed sensory trace and a longer-lasting short-term memory, and the distinctiveness of the stimuli was varied. Despite these precautions, slow-acting trace decay was observed. It therefore appears that the mere passage of time can lead to forgetting in some forms of short-term memory.     

Sex differences of parental phubbing on online hostility among adolescents: A moderated mediation model

To explore the relationship between parental phubbing (PP) and adolescent online hostility and its' psychological mechanism, 689 Chinese adolescents were recruited to complete a paper-and-pencil questionnaire. We took cyber flaming (CF) as an overall category for hostile online communication to investigate the relationship between PP and CF and the mediating role of perspective-taking (PT) in this relationship and examined whether there is a sex difference in this process. After controlling the average daily online time, the results showed that PP predicted adolescent CF positively. The relationship between PP and CF was partially mediated by PT. The effect of PP on PT was moderated by sex, with the result being significant only for boys. Related findings and future directions were discussed.     

When the “Charm of Three” Fades: Mental Imagery Moderates the Impact of the Number of Ad Claims on Persuasion

Given the prevalence of imagery appeals in today’s marketplace, the current research studies the role of mental imagery in how consumers process and react to advertisements with different numbers of ad claims. Past research has proposed “three” as the magical number of ad claims that maximizes persuasion, with more than three ad claims increasing skepticism and reducing evaluation. In the current research, we replicate this so-called “charm of three” effect, but only when consumers do not engage in mental imagery; when they do, however, we find that the effect is moderated, in that more ad claims beyond three produces more favorable product evaluation. Additionally, we provide evidence that the moderating effect of mental imagery is driven by transportation and skepticism toward the ad claims, with mental imagery increasing transportation and decreasing skepticism when there are more than three ad claims. Our research contributes to a better understanding of the “charm of three” effect, its boundary conditions, and underlying mechanism.     

城镇化进程中离乡农民心理健康特点调查及心理素质、相对剥夺感的影响机制

为探讨城镇化进程中离乡农民的心理健康特点以及心理素质、相对剥夺感对其的影响,通过量表对1339名城乡居民进行调查。结果发现:离乡与留乡农民在幸福感、拥有生命意义感、感知控制感、心理素质方面显著低于城镇居民,在状态焦虑方面显著高于城镇居民; 离乡农民在抑郁上显著高于城镇居民,在感知控制感上显著高于留乡农民,在心理素质上显著低于留乡农民; 留乡农民在相对剥夺感上显著高于城镇居民; 离乡农民的幸福感、拥有生命意义感、感知控制感态与相对剥夺感呈显著负相关,与心理素质呈显著正相关; 离乡农民的抑郁、状态焦虑与相对剥夺感呈显著正相关,与心理素质呈显著负相关; 离乡农民的相对剥夺感与心理素质之间呈显著负相关。心理素质除了可以直接预测心理健康各项指标,还可以通过相对剥夺感的中介作用,间接预测幸福感、抑郁及状态焦虑。提升心理素质和降低相对剥夺感是离乡农民心理健康服务的重要切入点。     

Regulatory Focus as a Mediator between Perceived Parenting Style and Friendship Intimacy in Chinese Emerging Adulthood

Journal of Child and Family Studies - In this study, we examined the relationship continuity between parent–child relationships and friendships. Based on the theoretical framework of the...     

Children’s Life Satisfaction: Developmental Trajectories and Environmental and Personality Predictors

Life satisfaction is a key indicator of children’s healthy development. Although the developmental changes of life satisfaction during adolescence have been investigated, the developmental trajectories of life satisfaction and related predictors during childhood remain unclear. Thus, the current study aimed to identify the developmental trajectories of life satisfaction covering the period from middle to late childhood as well as to examine the predictive roles of environmental factors (i.e., family dysfunction and basic psychological needs satisfaction at school), personality factors (i.e., neuroticism and extraversion), and their interactions in these developmental trajectories. An accelerated longitudinal design was used with Chinese elementary school students (N?=?1069, 45.8% girls, M _age?=?9.43, SD?=?0.95) of 3 cohorts (grade 3, grade 4, and grade 5) on 4 occasions at 6-month intervals. Growth mixture modeling analyses revealed three distinct trajectories of life satisfaction: “High-Stable” (88.8%), “High-Decreasing” (6.8%), and “Low-Increasing” (4.4%). Multivariate logistic regression analyses revealed that family dysfunction and neuroticism served as risk factors for adverse developmental trajectories of life satisfaction; whereas basic psychological needs satisfaction at school served as a protective factor. Furthermore, the interaction between family dysfunction and extraversion suggested that higher levels of extraversion buffered children against the negative effect of family dysfunction on the development of life satisfaction. The identification of three heterogeneous trajectory groups of children’s life satisfaction and key personality and environmental predictors associated with the trajectories suggests that specific interventions need to be tailored to the unique characteristics of the relevant trajectory groups.