Portability of a screener for pediatric bipolar disorder to a diverse setting

Robust screening measures that perform well in different populations could help improve the accuracy of diagnosis of pediatric bipolar disorder. Changes in sampling could influence the performance of items and potentially influence total scores enough to alter the predictive utility of scores. Additionally, creating a brief version of a measure by extracting items from a longer scale might cause differential functioning due to context effects. The authors of current study examined both sampling and context effects of a brief measure of pediatric mania. Caregivers of 813 youths completed the parent-reported version of the General Behavior Inventory (PGBI) at an academic medical center sample enriched for mood disorders. Caregivers of 481 youths completed the PGBI at a community mental health center. Caregivers of 799 youths completed 10 items extracted from the PGBI at a community setting. Caregivers of 159 youths completed both versions of the PGBI and a semistructured diagnostic interview. Differential item functioning indicated that across samples some items functioned differently; however, total observed scores were similar across all levels of mania. Receiver operating characteristic analysis indicated that the 10 extracted items discriminated bipolar disorder from nonbipolar behavior as well as when the items were embedded within the full measure. Findings suggest that the extracted items perform similarly to the embedded items in the community setting. Measurement properties appear sufficiently robust across settings to support clinical applications.     

Impaired sequential and partially compensated probabilistic skill learning in Parkinson's disease

The striatal dopaminergic dysfunction in Parkinson's disease (PD) has been associated with deficits in skill learning in numerous studies, but some of the findings remain controversial. Our aim was to explore the generality of the learning deficit using two widely reported skill learning tasks in the same group of Parkinson's patients. Thirty-four patients with PD (mean age: 62.83 years, SD: 7.67) were compared to age-matched healthy adults. Two tasks were employed: the Serial Reaction Time Task (SRT), testing the learning of motor sequences, and the Weather Prediction (WP) task, testing non-sequential probabilistic category learning. On the SRT task, patients with PD showed no significant evidence for sequence learning. These results support and also extend previous findings, suggesting that motor skill learning is vulnerable in PD. On the WP task, the PD group showed the same amount of learning as controls, but they exploited qualitatively different strategies in predicting the target categories. While controls typically combined probabilities from multiple predicting cues, patients with PD instead focused on individual cues. We also found moderate to high correlations between the different measures of skill learning. These findings support our hypothesis that skill learning is generally impaired in PD, and can in some cases be compensated by relying on alternative learning strategies.     

Different Associations of Health Related Quality of Life with Pain,Psychological Distress and Coping Strategies in Patients with Irritable Bowel Syndrome and Inflammatory Bowel Disorder

The primary aim of this study was to measure psychological distress, pain severity, health related quality of life (QOL) and pain coping strategies in patients with irritable bowel syndrome (IBS) and ulcerative colitis (UC). A second aim was to determine the influence of somatic and psychological variables on health related QOL. Eighty-eight IBS and 66 UC patients completed the Irritable Bowel Syndrome Quality of Life Questionnaire (IBSQOL), Pain Severity Scale of West Haven Yale Multidimensional Pain Inventory (WHYMPY), Symptom Checklist-90-R (SCL-90-R) and Coping Strategies Questionnaire (CSQ). T-tests and GLM Analysis of Covariance were used for statistical analysis. IBS patients had significantly higher levels of psychological distress, pain severity and maladaptive pain coping strategies (catastrophization), and lower QOL than UC patients. Variance of QOL in IBS was explained for the most part by catastrophization (15%), then by psychological distress (8%), and for the less part by pain severity (5%). In UC, pain severity explained 21%, psychological distress 8%, and catastrophization 3% of the variance of QOL. These results suggest there are differences between IBS and UC patients in the role of physical and psychological factors in QOL and emphasize the importance of cognitive processes in IBS.     

Hume's Experimental Method

In this article I attempt to reconstruct David Hume's use of the label ‘experimental’ to characterise his method in the Treatise. Although its meaning may strike the present-day reader as unusual, such a reconstruction is possible from the background of eighteenth-century practices and concepts of natural inquiry. As I argue, Hume's inquiries into human nature are experimental not primarily because of the way the empirical data he uses are produced, but because of the way those data are theoretically processed. He seems to follow a method of analysis and synthesis quite similar to the one advertised in Newton's Opticks, which profoundly influenced eighteenth-century natural and moral philosophy. This method brings him much closer to the methods of qualitative, chemical investigations than to mechanical approaches to both nature and human nature.     

The sociological tradition of Hungarian philosophy

In this introductory paper I sketch the tradition, several early aspects of which are discussed in the following essays and reviews. I introduce the main figures whose work initiated and maintained the sociological orientation in Hungarian philosophy thereby tracing its evolution. I suggest that its sociological outlook, if taken to be a characteristic tendency that gives Hungarian philosophy its distinctive flavour, provides us with the framework of a possible narrative about the history of Hungarian philosophy in the broader context of Central European philosophy. This narrative, in turn, suggests a way of integrating the latter into the history of Western philosophy rather than restricting its scope to a handful of canonical works only.     

Before the Two Cultures: Merging the Canons of the History of Science and Philosophy

This article argues that early modern philosophy should be seen as an integrated enterprise of moral and natural philosophy. Consequently, early modern moral and natural philosophy should be taught as intellectual enterprises that developed hand in hand. Further, the article argues that the unity of these two fields can be best introduced through methodological ideas. It illustrates these theses through a case study on Scottish Newtonianism, starting with visions concerning the unity of philosophy and then turning to a discussion of how methodological ideas figure in those visions. Finally, the article argues that methodological considerations can serve as good starting points to introduce and discuss central topics and canonical figures of the early modern period.     

Author Productivity Index: Without Distortions

Science and Engineering Ethics -     

Hume on the social construction of mathematical knowledge

Mathematics for Hume is the exemplary field of demonstrative knowledge. Ideally, this knowledge is a priori as it arises only from the comparison of ideas without any further empirical input; it is certain because demonstration consist of steps that are intuitively evident and infallible; and it is also necessary because the possibility of its falsity is inconceivable as it would imply a contradiction. But this is only the ideal, because demonstrative sciences are human enterprises and as such they are just as fallible as their human practitioners. According to the reading suggested here, Hume develops a radical sceptical challenge for mathematics, and thereby he undermines the knowledge claims associated with demonstrative reasoning. But Hume does not stop there: he also offers resources for a sceptical solution to this challenge, one that appeals crucially to social practices, and sketches the social genealogy of a community-wide mathematical certainty. While explaining this process, he relies on the conceptual resources of his faculty psychology that helps him to distinguish between the metaphysics and practices of mathematical knowledge. His account explains why we have reasons to be dubious about our reasoning capacities, and also how human nature and sociability offers some remedy from these epistemic adversities.