Intensive training of phonological skills in progressive aphasia: a model of brain plasticity in neurodegenerative disease

Three patients with a typical syndrome of nonfluent primary progressive aphasia (Mesulam's syndrome) were trained daily with a remediation protocol including auditory exercises specifically designed to involve several aspects of phonological processing, a domain known to be specifically affected in the condition. The speech content of the exercises was based on the temporal theory of phonological processes according to which increasing the duration of formant transition should facilitate phoneme discrimination and phoneomic awareness. Significantly improved performance on the trained tasks was demonstrated in the three patients. Improvement further generalized to other tasks such as nonword repetition and reading. We conclude that such results (1) argue for using intensive focused therapy of language impairment in neurodegenerative disorders, (2) may constitute a good model of brain plasticity in neurodegenerative disorders in general, and (3) support theories of phonological processing emphasizing temporal features of the auditory signal.     

Construct validity of the Global Assessment of Functioning Scale for clients with anxiety disorder

The Global Assessment of Functioning Scale is a widely used although poorly researched measurement of overall mental health or illness. This study investigated construct validity for clients with anxiety disorder. Analysis suggests that current suicidality was the most significant predictor of ratings. Current homicidality, work/school problems, and inability to care for oneself were not significantly correlated with scale ratings.     

Binding neutral information to emotional contexts: Brain dynamics of long-term recognition memory

There is abundant evidence in memory research that emotional stimuli are better remembered than neutral stimuli. However, effects of an emotionally charged context on memory for associated neutral elements is also important, particularly in trauma and stress-related disorders, where strong memories are often activated by neutral cues due to their emotional associations. In the present study, we used event-related potentials (ERPs) to investigate long-term recognition memory (1-week delay) for neutral objects that had been paired with emotionally arousing or neutral scenes during encoding. Context effects were clearly evident in the ERPs: An early frontal ERP old/new difference (300–500 ms) was enhanced for objects encoded in unpleasant compared to pleasant and neutral contexts; and a late central-parietal old/new difference (400–700 ms) was observed for objects paired with both pleasant and unpleasant contexts but not for items paired with neutral backgrounds. Interestingly, objects encoded in emotional contexts (and novel objects) also prompted an enhanced frontal early (180–220 ms) positivity compared to objects paired with neutral scenes indicating early perceptual significance. The present data suggest that emotional—particularly unpleasant—backgrounds strengthen memory for items encountered within these contexts and engage automatic and explicit recognition processes. These results could help in understanding binding mechanisms involved in the activation of trauma-related memories by neutral cues.     

‘What meaning does somebody's death have,what meaning does somebody's life have?’ Psychotherapists’ stories of their work with suicidal clients

Working with suicidal clients is perceived to be demanding and anxiety provoking for psychotherapists. This investigation explores what it is like for psychotherapists who work with suicidal clients, particularly as within the prevailing culture there is an increasing focus on strategies aimed at suicide prevention. Five themes were identified through narrative analysis, with support systems such as supervision and peer support being seen as vital in surviving working with suicidal clients. However, there is also ambivalence about involving other professionals, such as mental health services, as there is a sense that to do so may be anti-therapeutic and unhelpful to the client. Overall, what emerges from this study is that it is important to challenge the prevailing culture in which a medical discourse is dominant, in order to find a different way of talking about suicide and despair.     

Cross-modal and intra-modal binding between identity and location in spatial working memory: The identity of objects does not help recalling their locations

In this study we tested incidental feature-to-location binding in a spatial task, both in unimodal and cross-modal conditions. In Experiment 1 we administered a computerised version of the Corsi Block-Tapping Task (CBTT) in three different conditions: the first one analogous to the original CBTT test; the second one in which locations were associated with unfamiliar images; the third one in which locations were associated with non-verbal sounds. Results showed no effect on performance by the addition of identity information. In Experiment 2, locations on the screen were associated with pitched sounds in two different conditions: one in which different pitches were randomly associated with locations and the other in which pitches were assigned to match the vertical position of the CBTT squares congruently with their frequencies. In Experiment 2 we found marginal evidence of a pitch facilitation effect in the spatial memory task. We ran a third experiment to test the same conditions of Experiment 2 with a within-subject design. Results of Experiment 3 did not confirm the pitch–location facilitation effect. We concluded that the identity of objects does not affect recalling their locations. We discuss our results within the framework of the debate about the mechanisms of “what” and “where” feature binding in working memory.     

An olfactometer for small rodents

An olfactometer that captures and delivers biological odors at experimenter-controlled times, without dilution, is described. The apparatus is quiet, efficient, versatile, animal-safe, and fairly inexpensive. Tests indicate that the device is successful in isolating transitory odors.     

Sex stereotypes and implicit personality theory: Toward a cognitive—Social psychological conceptualization

Progress in understanding sex stereotypes has been impeded by the failure of researchers to address two critical conceptual questions: What is a sex stereotype? How do sex stereotypes function in social cognition and behavior? As a step toward answering the first question, the meaning of the term “sex stereotype” was considered. On the basis of points of agreement among extant conceptual definitions of the construct “stereotype” (in both the female-male and ethnic relations literatures), a generic definition of “sex stereotypes” is proposed: the structured sets of beliefs about the personal attributes of women and of men. In order to relate sex stereotypes more closely to research and theory on “normal” psychological processes, this basic definition is recast in terms of the person perception construct, “implicit personality theory”: the structured sets of inferential relations that link personal attributes to the social categories female and male. Two studies are presented to illustrate the utility of this translation. The remainder of the article addresses the second question. Here we offer preliminary ideas regarding a more general cognitive—social psychological framework for the study of sex stereotypes. Stereotype and stereotyping are distinguished, and each is discussed in light of relevant research in cognitive and social psychology.     

Are crossmodal correspondences relative or absolute? Sequential effects on speeded classification

Crossmodal correspondences have often been demonstrated using congruency effects between pairs of stimuli in different sensory modalities that vary along separate dimensions. To date, however, it is still unclear the extent to which these correspondences are relative versus absolute in nature: that is, whether they result from pre-defined values that rigidly link the two dimensions or rather result from flexible values related to the previous occurrence of the crossmodal stimuli. Here, we investigated this issue in a speeded classification task featuring the correspondence between auditory pitch and visual size (e.g., congruent correspondence between high pitch/small disc and low pitch/large disc). Participants classified the size of the visual stimuli (large vs. small) while hearing concurrent high- or low-pitched task-irrelevant sounds. On some trials, visual stimuli were paired instead with “intermediate” pitch, that could be interpreted differently according to the auditory stimulus on the preceding trial (i.e., as “lower” following the presentation of a high pitch tone, but as “higher” following the presentation of a low pitch tone). Performance on sequence-congruent trials (e.g., when a small disc paired with the intermediate-pitched tone was preceded by a low pitch tone) was compared to sequence-incongruent trials (e.g., when a small disc paired with the intermediate-pitch tone was by a high-pitched tone). The results revealed faster classification responses on sequence-congruent than on sequence-incongruent trials. This demonstrates that the effect of the pitch/size correspondence is relative in nature, and subjected to trial-by-trial interpretation of the stimulus pair.