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31.
Darcq E Koebel P Del Boca C Pannetier S Kirstetter AS Garnier JM Hanauer A Befort K Kieffer BL 《Learning & memory (Cold Spring Harbor, N.Y.)》2011,18(9):574-578
RSK2 is a Ser/Thr kinase acting in the Ras/MAPK pathway. Rsk2 gene deficiency leads to the Coffin-Lowry Syndrome, notably characterized by cognitive deficits. We found that mrsk2 knockout mice are unable to associate an aversive stimulus with context in a lithium-induced conditioned place aversion task requiring both high-order cognition and emotional processing. Virally mediated shRNA-RSK2 knockdown in the habenula, whose involvement in cognition is receiving increasing attention, also ablated contextual conditioning. RSK2 signaling in the habenula, therefore, is essential for this task. Our study reveals a novel role for RSK2 in cognitive processes and uncovers the critical implication of an intriguing brain structure in place aversion learning. 相似文献
32.
Valladolid-Acebes I Stucchi P Cano V Fernández-Alfonso MS Merino B Gil-Ortega M Fole A Morales L Ruiz-Gayo M Del Olmo N 《Neurobiology of learning and memory》2011,95(1):80-85
It has been suggested that hyperglycemia and insulin resistance triggered by energy-dense diets can account for hippocampal damage and deficits of cognitive behaviour. We wonder if the impairment of learning and memory processes detected in diet-induced obese (DIO) mice is linked to diet composition itself. With this purpose we have evaluated learning performance in mice undergoing a short-term high-fat (HF) treatment, which leads to a pre-obese state characterized by increased adiposity without significant changes of glucose and insulin plasma levels. C57BL/6J mice were fed either a HF (45 kcal% from fat) or control diet (10 kcal% from fat) during 8 weeks. Learning performance was evaluated by using the four-arm baited version of the eight-arm radial maze test (RAM). Mice were trained to learn the RAM protocol and then memory was tested at different time-points. Time spent to consume food placed in baited arms and errors committed to find them were measured in all sessions. DIO mice significantly spent more time in learning the task and made a greater number of errors than controls. Moreover, retention tests revealed that both working and total memory errors were also more numerous in DIO mice. The current results show that short-term DIO impairs spatial learning and suggest that impairment of hippocampal learning elicited by HF diets might be perceptible before metabolic alterations linked to obesity develop. 相似文献
33.
Del Villar F García González L Iglesias D Perla Moreno M Cervelló EM 《Perceptual and motor skills》2007,104(2):355-365
This study deals with decision and execution behavior of tennis players during competition. The study is based on the expert-novice paradigm and aims to identify differences between both groups in the decision-making and execution variables in serve and shot actions in tennis. Six expert players (elite Spanish tennis players) and six novice players (grade school tennis players) took part in this study. To carry out this study, the observation protocol defined by McPherson and Thomas in 1989, in which control, decision-making and execution variables were included, was used, where it was applied to the performance of the tennis player in a real match situation. In the analysis, significant differences between experts and novices in decision-making and execution variables are found wherein it can be observed that experts display a greater ability to make the appropriate decisions, selecting the most tactical responses to put pressure on the opponent. Expert tennis players were also able to carry out forceful executions to their opponent with greater efficiency, making the opponent's response to a large extent more difficult. These findings are in accordance with those of McPherson and colleagues. 相似文献
34.
F R Brush S N Del Paine L J Pellegrino I M Rykaszewski N K Dess P Y Collins 《Journal of comparative psychology (Washington, D.C. : 1983)》1988,102(4):337-349
The Syracuse strains of Long-Evans rats were selectively bred for good (SHA) or poor (SLA) avoidance learning in a two-way shuttle box, which resulted in a phenotypic difference that is correlated with behavior patterns indicative of emotional reactivity, SLA animals showing evidence of greater emotional reactivity than SHA animals. The first three experiments examined conditioned suppression of bar pressing and compared paired and unpaired conditioned- and unconditioned-stimulus presentations to evaluate the influence of conditioning versus primary aversive stimulation on baseline responding. SLA animals acquired conditioned suppression faster than SHA animals and also showed greater suppression of baseline responding than SHA animals. In Experiment 4, SLA animals learned a passive-avoidance task faster than SHA animals. In Experiment 5, SLA animals showed greater stress-induced suppression of drinking a weak quinine solution than SHA animals. These data are consistent with the hypothesis that SLA animals are more emotionally reactive than SHA animals. 相似文献
35.
Two experiments were conducted to assess sex stereotypes using the trait-inference method originated by Asch (1946). In both, subjects were asked to make inferences about the personality of a male or a female stimulus target who was introduced by a brief list of traits. In Experiment 1 this trait list described the target as either good or bad in intellectual activities and as either warm or cold while in Experiment 2 the introductory list comprised traits which are relatively neutral in terms of evaluation. Subjects rated the stimulus persons on adjective scales selected to reflect dimensions of personality perception reported in previous research. In both studies, male targets were rated significantly higher than females in terms of the Intellectual Desirability dimension. In addition, female targets tended to be rated higher on Communion in Experiment 1 (p<.06), and lower than males on Potency in Experiment 2 (p<.07). No differences as a function of stimulus sex were obtained for Social Desirability, Activity, and Agency. The results suggest that the dimension of implicit personality theory most closely associated with perceived sex differences is a combination of Intellectual Desirability and Potency. The male end of this dimension is relatively well defined by traits which convey a hard-headed, rational approach to problem solving. The female end is much less elaborated and consists of traits reflecting soft-heartedness. 相似文献
36.
These experiments examine the relationship between subjects' familiarity judgements of words of similar (low) frequency and their recall or recognition of these words. The expected relationship between familiarity and recall was well confirmed, as was the less expected relationship between familiarity and recognition. An analysis of the vocabulary acquisition process led to more specific predictions about performance on delayed, as compared with immediate, retention tests. The most crucial of these predictions was that words which are familiar, but whose meanings are not known, are remembered by tagging sets of phonological (as opposed to semantic) features, leading to good immediate recall but poor delayed recall, and a greater likelihood of acoustic confusions following a delay. Some support was obtained for these predictions. However, subjects showed unexpectedly good retention of unknown words and it was felt that tagging alone does not account for all the findings. 相似文献
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38.
Ellis BJ Del Giudice M Dishion TJ Figueredo AJ Gray P Griskevicius V Hawley PH Jacobs WJ James J Volk AA Wilson DS 《Developmental psychology》2012,48(3):598-623
This article proposes an evolutionary model of risky behavior in adolescence and contrasts it with the prevailing developmental psychopathology model. The evolutionary model contends that understanding the evolutionary functions of adolescence is critical to explaining why adolescents engage in risky behavior and that successful intervention depends on working with, instead of against, adolescent goals and motivations. The current article articulates 5 key evolutionary insights into risky adolescent behavior: (a) The adolescent transition is an inflection point in development of social status and reproductive trajectories; (b) interventions need to address the adaptive functions of risky and aggressive behaviors like bullying; (c) risky adolescent behavior adaptively calibrates over development to match both harsh and unpredictable environmental conditions; (d) understanding evolved sex differences is critical for understanding the psychology of risky behavior; and (e) mismatches between current and past environments can dysregulate adolescent behavior, as demonstrated by age-segregated social groupings. The evolutionary model has broad implications for designing interventions for high-risk youth and suggests new directions for research that have not been forthcoming from other perspectives. 相似文献
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