Exposure to acute physical and psychological stress alters the response of rat macrophages to corticosterone, neuropeptide Y and beta-endorphin

The objective of the present study was to investigate the effect of acute exposure to electric tail shock stress (ES) and a stress witnessing procedure (SW), as models for physical and psychological stress paradigms, respectively on adherence, phagocytosis and hydrogen peroxide (H(2)O(2)) release from rat peritoneal macrophages. In addition, we studied the in vitro effects of corticosterone (CORT), neuropeptide Y (NPY) and beta-endorphin (BE) on adherence, phagocytosis and H(2)O(2) release from macrophages isolated from control rats and from rats that had been exposed to ES or SW procedures 24 h earlier. ES and SW comparably diminished phagocytosis and H(2)O(2) release, but did not influence macrophage adherence. In vitro treatment with CORT and NPY notably suppressed phagocytosis and potentiated H(2)O(2) release from macrophages. BE suppressed both phagocytosis and H(2)O(2) release from macrophages. Previous exposure to ES and SW altered the responsiveness of the isolated macrophages to their in vitro treatment with mediators of stress, making the cells less sensitive to the influence of CORT and NPY and to a lesser extent to BE. It could be concluded that changes in the local macrophage milieu induced by ES and SW 24 h earlier modify macrophage responses to subsequent in vitro exposure to the stress mimics, CORT, NPY and BE.     

Objective Consequentialism and the Rationales of ‘ “Ought” Implies “Can” ’

This paper argues that objective consequentialism is incompatible with the rationales of ‘ “ought” implies “can” ’ – with the considerations, that is, that explain or justify this principle. Objective consequentialism is the moral doctrine that an act is right if and only if there is no alternative with a better outcome, and wrong otherwise. An act is obligatory if and only if it is wrong not to perform it. According to ‘ “ought” implies “can” ’, a person is morally obligated to φ only if the person can φ. The rationales of ‘ “ought” implies “can” ’ include considerations related to intuitive plausibility, action‐guidance, blameworthiness and fairness, and the nature of practical reasons. 1     

Bidirectional Effects between Parenting and Aggressive Child Behavior in the Context of a Preventive Intervention

Over time, developmental theories and empirical studies have gradually started to adopt a bidirectional viewpoint. The area of intervention research is, however, lagging behind in this respect. This longitudinal study examined whether bidirectional associations between (changes in) parenting and (changes in) aggressive child behavior over time differed in three conditions: a child intervention condition, a child + parent intervention condition and a control condition. Participants were 267 children (74 % boys, 26 % girls) with elevated levels of aggression, their mothers and their teachers. Reactive aggression, proactive aggression and perceived parenting were measured at four measurement times from pretest to one-year after intervention termination. Results showed that associations between aggressive child behavior and perceived parenting are different in an intervention context, compared to a general developmental context. Aggressive behavior and perceived parenting were unrelated over time for children who did not receive an intervention. In an intervention context, however, decreases in aggressive child behavior were related to increases in perceived positive parenting and decreases in perceived overreactivity. These findings underscore the importance of addressing child-driven processes in interventions aimed at children, but also in interventions aimed at both children and their parents.     

Facilitating empathy through virtual reality

This research experimentally investigated whether virtual reality experience can prompt greater empathy and whether greater engagement with a virtual reality connects this virtual reality experience to empathy. Randomly assigned participants viewed a documentary featuring a young girl living in a refugee camp either in a virtual reality format or in a control two-dimensional format. Results indicated that the virtual reality experience resulted in greater engagement and a higher level of empathy for the refugee girl compared to the control condition. Greater engagement was a process connecting the virtual reality experience to empathy. Virtual reality has the potential to influence interpersonal emotions such as empathy.     

Development and initial validation of the comprehensive early childhood parenting questionnaire (CECPAQ) for parents of 1–4 year-olds

Parenting is a multifaceted task and the way in which parents fulfill this task plays an important role in children’s growth and development, especially in early childhood. Conceptualization and assessment of parenting behavior is elementary for research on child and family development and would fill a gap in clinical work, as there is a lack of questionnaires simultaneously assessing multiple parenting behaviors specific for early childhood. Therefore the Comprehensive Early Childhood Parenting Questionnaire (CECPAQ) was designed; a parent report measure of commonly occurring behaviors in five domains of parenting (i.e., support, stimulation, structure, harsh discipline, and positive discipline) central to early childhood. Data were collected from 1139 mothers and 526 fathers of 1–4 year-old children. Confirmatory factor analysis confirmed a five-factor structure (composed of 54 items). The five parenting domains were found to have good internal consistency and temporal stability. Preliminary evidence of validity of the CECPAQ was demonstrated by moderate relationships with measures of parental stress and child problem behavior. It is concluded that the CECPAQ is a promising measure of self-perceived parenting behavior for parents of 1–4 year-old children.     

Predicting sugar-sweetened behaviours with theory of planned behaviour constructs: Outcome and process results from the SIPsmartER behavioural intervention

Objective: Guided by the theory of planned behaviour (TPB) and health literacy concepts, SIPsmartER is a six-month multicomponent intervention effective at improving SSB behaviours. Using SIPsmartER data, this study explores prediction of SSB behavioural intention (BI) and behaviour from TPB constructs using: (1) cross-sectional and prospective models and (2) 11 single-item assessments from interactive voice response (IVR) technology.

Design: Quasi-experimental design, including pre- and post-outcome data and repeated-measures process data of 155 intervention participants.

Main Outcome Measures: Validated multi-item TPB measures, single-item TPB measures, and self-reported SSB behaviours. Hypothesised relationships were investigated using correlation and multiple regression models.

Results: TPB constructs explained 32% of the variance cross sectionally and 20% prospectively in BI; and explained 13–20% of variance cross sectionally and 6% prospectively. Single-item scale models were significant, yet explained less variance. All IVR models predicting BI (average 21%, range 6–38%) and behaviour (average 30%, range 6–55%) were significant.

Conclusion: Findings are interpreted in the context of other cross-sectional, prospective and experimental TPB health and dietary studies. Findings advance experimental application of the TPB, including understanding constructs at outcome and process time points and applying theory in all intervention development, implementation and evaluation phases.     

Function transformation without reinforcement

In studies of function transformation, participants initially are taught to match stimuli in the presence of a contextual cue, X; the stimuli to be matched bear some formal relation to each other, for example, a relation of opposition or difference. In a second phase, the participants are taught to match arbitrary stimuli (say, A and B) in the presence of X. In a final test, A often displays behavioral functions that differ from those of B, and can be predicted from the nature of the relation associated with X in the initial training phase. Here we report function-transformation effects in the absence of selection responses and of their reinforcers. In three experiments with college students, exposure to relations of difference or identity modified the responses given to later stimuli. In Experiment 1, responses to a test stimulus A varied depending on preexposure to pairs of colors that were distinct from A but exemplified relations of difference or identity. In Experiment 2, a stimulus A acquired distinct functions, depending on its previous pairing with a contextual cue X that had itself been paired with identity or difference among colors. Experiment 3 confirmed the results of Experiment 2 with a modified design. Our data are consistent with the notion that relations of identity or difference can serve as stimuli for Pavlovian processes, and, in compound with other cues, produce apparent function-transformation effects.     

Interpretation of pronouns in VP-ellipsis constructions in Dutch Broca's and Wernicke's aphasia

In this paper, we investigate the ability of Dutch agrammatic Broca's and Wernicke's aphasics to assign reference to possessive pronouns in elided VP constructions. The assumption is that the comprehension problems in these two populations have different sources that are revealed in distinct patterns of responses. The focus is primarily on the performance of the agrammatic group whose errors in comprehension are not viewed as a consequence of a breakdown of grammatical knowledge but as a result of limited processing resources (for an overview see Grodzinsky, 2000). The results of the present study provide evidence for the psycholinguistic reality of the economy hierarchy as proposed in the Primitives of Binding (Reuland, 2001). According to the economy hierarchy proposed for the non-brain-damaged, the more economical semantic dependencies are preferred over the costlier discourse dependencies. This hierarchy is reflected in agrammatic aphasia where the semantic dependencies are available on time and preferred over the discourse dependences that are not available on time as a result of the lack of processing resources with consequences for comprehension.     

Reference assignment: using language breakdown to choose between theoretical approaches

We report results of an experimental study with Dutch agrammatic aphasics that investigated their ability to interpret pronominal elements in transitive clauses and Exceptional Case Marking constructions (ECM). Using the obtained experimental results as a tool, we distinguish between three competing linguistic theories that aim at determining principles responsible for pronoun distribution: Government and Binding (Chomsky, 1981), Reflexivity (Reinhart & Reuland, 1993), and Primitives of Binding (Reuland, 2001). The obtained results are inconsistent with Government and Binding, but consistent with the latter two theories. We further show that the Primitives of Binding framework most naturally explains our results. Our proposal is based on the different performance demonstrated by patients in transitive clauses and ECM constructions, in combination with the often-made claim in the literature regarding the limitation of processing resources in this population (e.g., Haarmann and Kolk, 1991, Haarmann and Kolk, 1994 and Zurif et al., 1993, among others).     

Treatment rejecting and treatment seeking personality disorders: Type R and Type S

An important distinguishing feature of one group of personality disorders is the wish of the sufferer to seek treatment. For another group this wish is rarely entertained. Although there is some variation between different types of personality disorder the wish to change is not confined to any one diagnostic category. A useful subclassification of personality disorders is therefore into Type R (treatment rejecting) and Type S (treatment seeking) personality disorders, and these are defined operationally. The classification of 68 personality disordered patients on the caseload of an assertive community team using a simple scale showed a 3 to 1 ratio between Type R and Type S personality disorders with Cluster C personality disorders being significantly more likely to be Type S, and paranoid and schizoid (Cluster A) personality disorders significantly more likely to be Type R than others. It is suggested that this typology is useful for those contemplating treatment with those who have personality disorders.