Test-retest reliability of fMRI during nonverbal semantic decisions in moderate-severe nonfluent aphasia patients

Cortical reorganization in poststroke aphasia is not well understood. Few studies have investigated neural mechanisms underlying language recovery in severe aphasia patients, who are typically viewed as having a poor prognosis for language recovery. Although test-retest reliability is routinely demonstrated during collection of language data in single-subject aphasia research, this is rarely examined in fMRI studies investigating the underlying neural mechanisms in aphasia recovery. The purpose of this study was to acquire fMRI test-retest data examining semantic decisions both within and between two aphasia patients. Functional MRI was utilized to image individuals with chronic, moderate-severe nonfluent aphasia during nonverbal, yes/no button-box semantic judgments of iconic sentences presented in the Computer-assisted Visual Communication (C-ViC) program. We investigated the critical issue of intra-subject reliability by exploring similarities and differences in regions of activation during participants' performance of identical tasks twice on the same day. Each participant demonstrated high intra-subject reliability, with response decrements typical of task familiarity. Differences between participants included greater left hemisphere perilesional activation in the individual with better response to C-ViC training. This study provides fMRI reliability in chronic nonfluent aphasia, and adds to evidence supporting differences in individual cortical reorganization in aphasia recovery.     

Unilateral forced nostril breathing affects dichotic listening for emotional tones

Unilateral forced nostril breathing (UFNB) through the left nostril is associated with enhanced spatial abilities, whereas UFNB through the right nostril is associated with enhanced verbal abilities. However, the effects of UFNB on standard tasks of laterality (e.g., dichotic listening) are unknown. This study employed dichotic listening for word targets, which typically exhibits a right ear advantage (REA), and dichotic listening for emotional targets, which typically exhibits a left ear advantage (LEA). Participants were asked to breathe either through their dominant nostril (congruent UFNB) or to breathe through their non-dominant nostril (incongruent UFNB) for the entire testing session. There was a significant three-way interaction between the type of dichotic listening task, nostril dominance, and nostril assignment, with the expected REA for word targets and the expected LEA for emotional targets-with one exception. Right nostril dominant participants assigned to the congruent condition exhibited an LEA for emotional targets (p < .05). The other three groups exhibited the expected LEA/right hemisphere advantage for the detection of emotional targets and all groups exhibited the expected REA/left hemisphere advantage for detection of word targets. As such, possible bias induced by tactile stimulation of the contralateral face cannot account for these results. Thus, our data are consistent with a selective enhancement of right hemispheric lateralized functions by right nostril UFNB.     

The success of Caucasian mothers in guiding adolescents

The purpose of this study was to determine how 391 Caucasian American mothers of 10- to 14-year-olds viewed their assets and limitations as parents and to find out how 352 adolescents perceived the parenting performance of their mothers. Both generations completed the Parent Success Indicator. It was found that the amount of time mothers spent talking to, and doing things with, their adolescent children had the greatest impact on how both generations rated mother success.     

Shyness: relationship to social phobia and other psychiatric disorders

The relationship between shyness, social phobia and other psychiatric disorders was examined. The prevalence of social phobia was significantly higher among shy persons (18%) compared with non-shy persons (3%). However, the majority of shy individuals (82%) were not socially phobic. A significant and positive correlation was found between the severity of shyness and the presence of social phobia, but the data suggest that social phobia is not merely severe shyness. Social phobia was also positively and moderately correlated with introversion and neuroticism. Thus, shy persons with social phobia were shyer, more introverted, and more neurotic than other shy people, but none of these factors was sufficient to distinguish shy persons with social phobia from those without social phobia. The proportion of the shy group with psychiatric diagnoses other than social phobia was significantly higher than among the non-shy group, indicating that various diagnostic categories are prominent among the shy. The results are discussed in terms of the overlap in shyness and social phobia and the relationship of shyness to other psychiatric diagnoses and personality dimensions.     

The developmental ecology of urban males' youth violence

Data from a longitudinal study of 294 African American and Latino adolescent boys and their caregivers living in poor urban communities were used to test a developmental-ecological model of violence. Six annual waves of data were applied to evaluate the relations between microsystem influences of parenting and peer deviance (peer violence and gang membership), macrosystem influences of community structural characteristics and neighborhood social organization, and individual involvement in violence (level and growth). Structural equation modeling analyses showed that community structural characteristics significantly predicted neighborhood social processes. Parenting practices partially mediated the relation between neighborhood social processes and gang membership. Parenting practices was fully mediated in its relation to peer violence by gang membership. Gang membership was partially mediated by peer violence level in its relation to individual violence level. Although the overall set of relations does not satisfy mediation requirements fully in all instances, the model was validated for the most part, supporting a focus on a multilevel ecological model of influences on risk development.     

Latent growth curve analyses of accelerating decline in cognitive abilities in late adulthood

Latent growth models were applied to data from the Swedish Adoption/Twin Study of Aging to discover if the rate of change in cognitive performance increased from middle age to later adulthood. The sample included 590 participants aged 44 to 88 years at first measurement. Data were gathered at 2 follow-up occasions at intervals of 3 years. Cognitive ability was assessed through 11 tests that tapped crystallized, fluid, memory, and spatial abilities and perceptual speed. Results indicated stability for measures of crystallized ability, linear age changes for many cognitive abilities, and a significant acceleration in linear decline after age 65 for measures with a large speed component. Gender differences were found only in mean level, not in rate of decline.     

Pathways to violence in the children of mothers who were depressed postpartum

The impact of postnatal depression on a child's risk for violent behavior was evaluated in an urban British community sample (N=122 families). Mothers were interviewed during pregnancy, at 3 months postpartum, and when the child was 1, 4, and 11 years of age. Mothers, teachers, and children reported on violent symptoms at age 11. Structural equation modeling revealed that the child's violence was predicted by the mother's postnatal depression even when her depression during pregnancy, her later history of depression, and family characteristics were taken into account. Violence was associated with symptoms of attention-deficit/hyperactivity disorder and problems with anger management. Children were most violent if mothers had been depressed at 3 months and at least once thereafter.