Neuropsychological Contributions to the Early Identification of Alzheimer’s Disease

A wealth of evidence demonstrates that a prodromal period of Alzheimer’s disease (AD) exists for some years prior to the appearance of significant cognitive and functional declines required for the clinical diagnosis. This prodromal period of decline is characterized by a number of different neuropsychological and brain changes, and reliable identification of individuals prior to the development of significant clinical symptoms remains a top priority of research. In this review we provide an overview of those neuropsychological changes. In particular, we examine specific domains of cognition that appear to be negatively affected during the prodromal period of AD, and we review newer analytic strategies designed to examine cognitive asymmetries or discrepancies between higher-order cognitive functions versus fundamental skills. Finally, we provide a critical examination of the clinical concept of Mild Cognitive Impairment and offer suggestions for an increased focus on the impact of cerebrovascular disease (CVD) and CVD risk during the prodromal period of AD.     

Interoceptive Cue Exposure for Depersonalization: A Case Series

Cognitive-behavioral treatment for panic disorder relies heavily on interoceptive exposure. Specifically, therapists induce physical symptoms associated with panic in order to produce habituation to those sensations. Many common symptoms of panic are easily induced, such as increased heart rate and dizziness. However, depersonalization is a difficult symptom to induce in the office. Three uncontrolled cases are presented here where a novel intervention, the use of 3D glasses, was used to successfully induce depersonalization with positive effect. The application of the procedure resulted in rapid habituation within session, and all three patients had significant reductions in panic following treatment. Additional research is necessary to examine the application of this, and other, novel methods for inducing depersonalization as part of a comprehensive approach to treating panic and other psychiatric conditions where depersonalization is present.     

‘Querying’ the Limits of Queering Boys Through the Contested Discourses on Sexuality

Presentations of boy’s sexuality within man–boy sexual relationships have shifted considerably over the past three decades. We document this through analyzing three very different constituencies: ‘boylover’ (adult men sexually attracted to boys) activist movements, three research case studies, and male survivors of abuse. We examine the specific ways boy’s sexuality has been constructed within each of these positions, how these have changed over this period, and what insights all this can shed on wider social and cultural (re)conceptions on age, gender, and sexuality. Studying these diverse perspectives provides a series of contrasting assumptions and frameworks which will yield invaluable insights on wider transformations in the production of narratives on child and intergenerational sexualities. We hope to illuminate this through drawing out the complex interplays involving power dynamics and fluctuations in the epistemological hierarchy delineating boy’s sexuality (in terms of more normative and transgressive forms this may take). We conclude this critical engagement with a discussion of the likely impact any ‘queering’ of, or fractures in, age/generational boundaries might have for the future narrating of boy’s sexual stories within man–boy sexual relationships.

Application of a Sensemaking Approach to Ethics Training in the Physical Sciences and Engineering

Integrity is a critical determinant of the effectiveness of research organizations in terms of producing high quality research and educating the new generation of scientists. A number of responsible conduct of research (RCR) training programs have been developed to address this growing organizational concern. However, in spite of a significant body of research in ethics training, it is still unknown which approach has the highest potential to enhance researchers' integrity. One of the approaches showing some promise in improving researchers' integrity has focused on the development of ethical decision-making skills. The current effort proposes a novel curriculum that focuses on broad metacognitive reasoning strategies researchers use when making sense of day-to-day social and professional practices that have ethical implications for the physical sciences and engineering. This sensemaking training has been implemented in a professional sample of scientists conducting research in electrical engineering, atmospheric and computer sciences at a large multi-cultural, multi-disciplinary, and multi-university research center. A pre-post design was used to assess training effectiveness using scenario-based ethical decision-making measures. The training resulted in enhanced ethical decision-making of researchers in relation to four ethical conduct areas, namely data management, study conduct, professional practices, and business practices. In addition, sensemaking training led to researchers' preference for decisions involving the application of the broad metacognitive reasoning strategies. Individual trainee and training characteristics were used to explain the study findings. Broad implications of the findings for ethics training development, implementation, and evaluation in the sciences are discussed.     

Social support group attendance is related to blood pressure, health behaviours, and quality of life in the Multicenter Lifestyle Demonstration Project

Changes in coronary risk factors, health behaviours, and health-related quality of life (HRQOL) were examined by tertiles of social support group attendance in 440 patients (21% females) with coronary artery disease. All patients participated in the Multicenter Lifestyle Demonstration Project (MLDP; eight hospital sites in the USA), an insurance-covered multi-component cardiac prevention program including dietary changes, stress management, exercise and group support for 1 year. Significant improvements in coronary risk factors, health behaviours, and HRQOL were noted at 1 year. Several of these improvements (i.e. systolic blood pressure, health behaviours, HRQOL) were related to social support group attendance, favoring those who attended more sessions. The associations between support group attendance to systolic blood pressure and to four HRQOL subscales (bodily pain, social functioning, mental health, and the mental health summary score) remained significant when controlling for changes in health behaviours, but dropped to a non-significant level for the HRQOL subscales 'physical functioning', 'general health' and 'role-emotional'. These results suggest an independent relationship of social support group attendance to systolic blood pressure while improvements in quality of life may be in part due to improved health behaviours facilitated by increased social support group attendance.     

Dynamic visual noise interferes with storage in visual working memory

Several studies have demonstrated that dynamic visual noise (DVN) does not interfere with memory for random matrices. This has led to suggestions that (a) visual working memory is distinct from imagery, and (b) visual working memory is not a gateway between sensory input and long-term storage. A comparison of the interference effects of DVN with memory for matrices and colored textures shows that DVN can interfere with visual working memory, probably at a level of visual detail not easily supported by long-term memory structures or the recoding of the visual pattern elements. The results support a gateway model of visuospatial working memory and raise questions about the most appropriate ways to measure and model the different levels of representation of information that can be held in visual working memory.     

Moderating and Intensifying Factors Influencing Forgiveness by Priests and Lay People

Factors that influence forgiveness were studied in relation to sexual abuse of children by priests. This study used a series of scenarios measuring conceptualization of forgiveness. The Santa Clara Strength of Religious Faith (Plante and Boccaccini 1997) was used to assess the strength of religious faith. Priests were more forgiving of the abusive priest and of the church than lay Catholics. Higher levels of spirituality were associated with likelihood to forgive. Forgiveness was more likely under moderating factors of one time abuse, apology, reconciliation, and life change, than under their intensifying matches. Results were discussed in terms of conflict resolution.     

Choking on the Money: Reward-Based Performance Decrements Are Associated With Midbrain Activity

ABSTRACT— A pernicious paradox in human motivation is the occasional reduced performance associated with tasks and situations that involve larger-than-average rewards. Three broad explanations that might account for such performance decrements are attentional competition (distraction theories), inhibition by conscious processes (explicit-monitoring theories), and excessive drive and arousal (overmotivation theories). Here, we report incentive-dependent performance decrements in humans in a reward-pursuit task; subjects were less successful in capturing a more valuable reward in a computerized maze. Concurrent functional magnetic resonance imaging revealed that increased activity in ventral midbrain, a brain area associated with incentive motivation and basic reward responding, correlated with both reduced number of captures and increased number of near-misses associated with imminent high rewards. These data cast light on the neurobiological basis of choking under pressure and are consistent with overmotivation accounts.     

The Irrelevance of Democracy to the Public Justification of Political Authority

Democracy can be a means to independently valuable ends and/or it can be intrinsically (or non-instrumentally) valuable. One powerful non-instrumental defence of democracy is based on the idea that only it can publicly justify political authority. I contend that this is an argument about the reasonable acceptability of political authority and about the requirements of publicity and that satisfying these requirements has nothing to do with whether a society is democratic or not. Democracy, then, plays no role in publicly justifying political authority. I also show that any non-instrumental defence of democracy must make claims about what justice requires and make several further claims that require substantial justification.