A Computational Evaluation of Sentence Processing Deficits in Aphasia

Individuals with agrammatic Broca's aphasia experience difficulty when processing reversible non‐canonical sentences. Different accounts have been proposed to explain this phenomenon. The Trace Deletion account (Grodzinsky, 1995, 2000, 2006) attributes this deficit to an impairment in syntactic representations, whereas others (e.g., Caplan, Waters, Dede, Michaud, & Reddy, 2007; Haarmann, Just, & Carpenter, 1997) propose that the underlying structural representations are unimpaired, but sentence comprehension is affected by processing deficits, such as slow lexical activation, reduction in memory resources, slowed processing and/or intermittent deficiency, among others. We test the claims of two processing accounts, slowed processing and intermittent deficiency, and two versions of the Trace Deletion Hypothesis (TDH), in a computational framework for sentence processing (Lewis & Vasishth, 2005) implemented in ACT‐R (Anderson, Byrne, Douglass, Lebiere, & Qin, 2004). The assumption of slowed processing is operationalized as slow procedural memory, so that each processing action is performed slower than normal, and intermittent deficiency as extra noise in the procedural memory, so that the parsing steps are more noisy than normal. We operationalize the TDH as an absence of trace information in the parse tree. To test the predictions of the models implementing these theories, we use the data from a German sentence—picture matching study reported in Hanne, Sekerina, Vasishth, Burchert, and De Bleser (2011). The data consist of offline (sentence‐picture matching accuracies and response times) and online (eye fixation proportions) measures. From among the models considered, the model assuming that both slowed processing and intermittent deficiency are present emerges as the best model of sentence processing difficulty in aphasia. The modeling of individual differences suggests that, if we assume that patients have both slowed processing and intermittent deficiency, they have them in differing degrees.     

Herbert Rosenfeld in Italy, 1978–1985

Abstract

In this paper, the author attempts to shed some light on Herbert Rosenfeld’s thought and his way of working when was in Italy during 1978–1985. In particular, the author would like to show, in a sketchy way, the evolution of his thought, with specific regard for the new way in which he looked at clinical practice at that time. In the author’s opinion, the Rosenfeld that he and his group met and got to know in Italy was able to open new horizons in clinical practice, implicitly questioning some of his own or his circle’s previous viewpoints.     

Cross‐cultural Generalizability of the Alternative Five‐factor Model Using the Zuckerman–Kuhlman–Aluja Personality Questionnaire

Several personality models are known for being replicable across cultures, such as the Five‐Factor Model (FFM) or Eysenck's Psychoticism–Extraversion–Neuroticism (PEN) model, and are for this reason considered universal. The aim of the current study was to evaluate the cross‐cultural replicability of the recently revised Alternative FFM (AFFM). A total of 15 048 participants from 23 cultures completed the Zuckerman–Kuhlman–Aluja Personality Questionnaire (ZKA‐PQ) aimed at assessing personality according to this revised AFFM. Internal consistencies, gender differences and correlations with age were similar across cultures for all five factors and facet scales. The AFFM structure was very similar across samples and can be considered as highly replicable with total congruence coefficients ranging from .94 to .99. Measurement invariance across cultures was assessed using multi‐group confirmatory factor analyses, and each higher‐order personality factor did reach configural and metric invariance. Scalar invariance was never reached, which implies that culture‐specific norms should be considered. The underlying structure of the ZKA‐PQ replicates well across cultures, suggesting that this questionnaire can be used in a large diversity of cultures and that the AFFM might be as universal as the FFM or the PEN model. This suggests that more research is needed to identify and define an integrative framework underlying these personality models. Copyright © 2016 European Association of Personality Psychology     

The Relative Contribution of a Typological versus a Dimensional Approach for Understanding Obsessive-Compulsive Symptoms in Adolescents

In order to better understand the heterogeneous nature of Obsessive-Compulsive (OC) symptoms, a typological or a dimensional approach can be used to structure the variety of symptoms into a set of core components. However, there is still no consensus on which approach is the most robust to predict several OC-related criterion measures, especially in adolescents. From this perspective, the current study empirically identified OC classes (i.e., types), and explored whether types or dimensions are the strongest predictors of adolescent OC-related criterion variables. To identify OC classes, we conducted latent class analysis on the Youth Obsessive-Compulsive Symptoms Scale (YOCSS; De Caluwé and De Clercq 2014) that was completed by 682 community and referred adolescents (71.4 % girls, 12–18 years old, mean age = 15.67, SD = 1.53), and we also computed OC dimension scores as outlined in De Caluwé and De Clercq (2014). We subsequently used hierarchical regression analysis to examine the incremental validity of the OC classes beyond the OC domains, and vice versa, in predicting several OC-related criterion variables that were completed by the adolescents or their mothers (N = 325). The results indicated that the two identified OC classes only differed quantitatively but not qualitatively, hence reflecting severity classes, and also showed that OC domains have significant effects beyond the effects of the OC classes, whereas the reverse did not hold. The dimensional approach appears to have the strongest predictive value for OC symptomatology in adolescents, leading to clinical implications for conceptualization and assessment of obsessive and compulsive problems in younger age groups.     

Of mice and marbles: Novel perspectives on burying behavior as a screening test for psychiatric illness

Burying forms part of the normal behavioral routine of rodents, although its expression is species-specific. However, it has been suggested that aberrant burying behavior, of which marble-burying (MB) is an example, may represent neophobic and/or compulsive-like behavior. In the present investigation, we assessed MB in an established animal model of obsessive–compulsive disorder (OCD)—namely, spontaneous stereotypy in the deer mouse—to establish whether high (H) stereotypy is associated with neophobia and/or another compulsive endophenotype, i.e. MB, as compared to nonstereotypical (N) controls. A three-trial, one-zone MB test was performed over three consecutive evenings both before and after chronic treatment with high-dose (50 mg/kg/day) oral escitalopram. Neophobia was measured via the number of marbles buried during the first pre- and posttreatment MB trials, and compulsive-like behavior via the number of marbles buried over all pre- and posttreatment MB trials. The data from the present study support earlier findings that burying is a normal behavioral routine (inherent burying behavior, IBB) that is expressed by all deer mice, irrespective of stereotypical cohort, and is not associated with either neophobia or compulsiveness. Indeed, chronic escitalopram treatment, which is similarly effective in treating clinical anxiety and OCD, as well as in attenuating H behavior, failed to influence IBB. Although 11 % of the animals presented with a unique burying endophenotype (high burying behavior), escitalopram also failed to attenuate said behavior, necessitating further investigation as to its relevance. In conclusion, MB cannot be regarded as a measure of anxiety-like or compulsive behavior in the deer mouse model of OCD.     

The fate of unattended stimuli and emotional habituation: Behavioral interference and cortical changes

The interference produced by the viewing of emotional distractors has been interpreted as evidence that emotional cues are processed in a fairly mandatory fashion, and that they divert attention from the primary ongoing task. However, few studies have examined how behavioral emotional interference varies with repeated presentation of the same emotional distractors. In two experiments, while participants were engaged in a parity judgment task, we investigated the effects of repetition of task-irrelevant emotional pictures, as reflected in both behavioral interference (Experiments 1 and 2) and neural activity (Experiment 2). Both experiments showed that the slowing of reaction times that was observed when viewing emotional, compared to neutral, scenes disappeared after only a few repetitions, suggesting diminished attention allocation to repeated emotional pictures. Conversely, in Experiment 2, neural correlates of picture processing revealed that the late positive potential (LPP) amplitude continued to be enhanced for emotional, compared to neutral, distractors despite picture repetition and the presence of a concurrent task. Altogether, these findings suggest that while evaluative processes are mandatory, and continue to engage cortico-limbic appetitive and defensive systems even after massive repetition, as suggested by the affective modulation of the LPP, attentional processes are not necessary after several repetitions of the same stimulus, as indicated by the rapid decline of behavioral emotional interference.     

Quantification of swim patterns in the morris water maze

Spatial learning and memory in rodents is most often assessed in the Morris water maze. Neurobiologists have to distinguish behavioral patterns to unravel underlying neuronal systems. We analyzed swim patterns of mice videotaped before and after training with a multitrial procedure in the water maze. In addition to traditional parameters, the animals’ position in relation to trained and other possible platform locations was estimated five times per second by an image analysis system. This parameter,cumulative distance to platform, was correlated with time spent in the platform quadrant but not with latency to and crossings of the platform location. We detected a subgroup of animals with concentric patterns within the group of spatial/persistent patterns. Random patterns were classified as well. Swim patterns before training were not predictive for the one after training. In summary, image analysis systems have made it very convenient to quantify behavior. Using their capacity, we have further improved the analysis of swim patterns, revealing animals’ different approaches to solve a problem.