Attitudes Toward Fragile X Mutation Carrier Testing from Women Identified in a General Population Survey

Fragile X syndrome is primarily due to a CGG repeat expansion found in the FMR1 X-linked gene. In a previous study, we conducted focus groups with women to assess their attitudes towards fragile X carrier screening. In this follow-up study, we conducted in-depth interviews of general population reproductive-age women who were identified as carriers. We explored their attitudes toward testing for carrier status of the fragile X mutation. These women underwent screening primarily to participate in a research project rather than in search of a diagnosis for specific symptoms. As such, these women were wholly unprepared for positive carrier results. Their responses about their results and carrier screening, in many cases, were being worked out over the course of the interview itself. The most salient finding of this work is the apparent lack of relevance of carrier status to these women. Many expressed that although the information could be relevant in the future, it is not relevant at this stage of their lives in terms of family planning (either with respect to having unaffected offspring or to premature ovarian failure) and personal relationships. Although issues of abortion seemed prominent in the focus groups, we found that carrier status did not have an apparent effect on women’s attitudes about termination. We hypothesize this may be related to the fact that women had not processed their new carrier status and had not related it to previously-formed personal opinions. The findings of this work have significant implications for genetic counseling and population screening. Genetic counselors should be mindful that general population women may not recognize the immediate importance of their carrier status even when literature is provided and discussed prior to providing a sample. As part of comprehensive genetic counseling, counselors should identify the reproductive life stage of the woman receiving the new information and help her identify when this information would be more meaningful in her life. Counselors can assist in setting up a personalized road map with specific types of services that will be more applicable to the woman as her carrier status becomes more relevant.     

Information structure expectations in sentence comprehension

In English, new information typically appears late in the sentence, as does primary accent. Because of this tendency, perceivers might expect the final constituent or constituents of a sentence to contain informational focus. This expectation should in turn affect how they comprehend focus-sensitive constructions such as ellipsis sentences. Results from four experiments on sluicing sentences (e.g., The mobster implicated the thug, but we can't find out who else) suggest that perceivers do prefer to place focus late in the sentence, though that preference can be mitigated by prosodic information (pitch accents, Experiment 2) or syntactic information (clefted sentences, Experiment 3) indicating that focus is located elsewhere. Furthermore, it is not necessarily the direct object, but the informationally focused constituent that is the preferred antecedent (Experiment 4). Expectations regarding the information structure of a sentence, which are only partly cancellable by means of overt focus markers, may explain persistent biases in ellipsis resolution.     

Nonlocal effects of prosodic boundaries

Placing a prosodic boundary before a phrase may influence its syntactic analysis. However, the boundary’s effect depends on the presence, size, and position of other, earlier, prosodic boundaries. In three experiments, we extend previous results about the effect of the position of the early boundary. In sentences in which a final phrase may modify either a local verb or an earlier verb, a boundary immediately after the first verb leads to more first-verb attachments than when the earlier boundary appears in another position between the two verbs (Experiments 1 and 2). This effect cannot be attributed to weaker effects of more distant boundaries (Experiment 2), but is likely due to the first verb being more prominent when a boundary immediately follows it, since similar effects are observed when the verb is accented (Experiment 3). The results support the informative boundary hypothesis and show that the impact of earlier, nonlocal boundaries is not fully uniform.     

Brain activation and deactivation during location and color working memory tasks in 11-13-year-old children

Using functional magnetic resonance imaging (fMRI) and n-back tasks we investigated whether, in 11-13-year-old children, spatial (location) and nonspatial (color) information is differentially processed during visual attention (0-back) and working memory (WM) (2-back) tasks and whether such cognitive task performance, compared to a resting state, results in regional deactivation. The location 0-back task, compared to the color 0-back task, activated segregated areas in the frontal, parietal and occipital cortices whereas no differentially activated voxels were obtained when location and color 2-back tasks were directly contrasted. Several midline cortical areas were less active during 0- and 2-back task performance than resting state. The task-induced deactivation increased with task difficulty as demonstrated by larger deactivation during 2-back than 0-back tasks. The results suggest that, in 11-13-year-old children, the visual attentional network is differently recruited by spatial and nonspatial information processing, but the functional organization of cortical activation in WM in this age group is not based on the type of information processed. Furthermore, 11-13-year-old children exhibited a similar pattern of cortical deactivation that has been reported in adults during cognitive task performance compared to a resting state.     

Differences in startle reactivity during the perception of angry and fearful faces

Emotion researchers often categorize angry and fearful face stimuli as "negative" or "threatening". Perception of fear and anger, however, appears to be mediated by dissociable neural circuitries and often elicit distinguishable behavioral responses. The authors sought to elucidate whether viewing anger and fear expressions produce dissociable psychophysiological responses (i.e., the startle reflex). The results of two experiments using different facial stimulus sets (representing anger, fear, neutral, and happy) indicated that viewing anger was associated with a significantly heightened startle response (p < .05) relative to viewing fear, happy, and neutral. This finding suggests that while anger and fear faces convey messages of "threat", their priming effect on startle circuitry differs. Thus, angry expressions, representing viewer-directed threat with an unambiguous source (i.e., the expresser), may more effectively induce a motivational propensity to withdraw or escape. The source of threat is comparatively less clear for fearful faces. The differential effects of these two facial threat signals on the defensive motivational system adds to growing literature highlighting the importance of distinguishing between emotional stimuli of similar valence, along lines of meaning and functional impact.     

Considerations Relating to the Study of Group Differences in Intelligence

ABSTRACT— There are signs that the debate over racial and gender differences in intelligence is about to begin again. In this article we will be concerned primarily with racial differences but will make remarks about gender differences where applicable. Previously there have been bitter arguments over whether or not races exist, over whether it is either important or proper to study racial and gender differences in intelligence, and over the conclusions that have been drawn about environmental and genetic causes as determinants of these differences. We argue that races do, indeed, exist and that studying differences in cognitive competence between groups is a reasonable thing to do. We also point out that past research on both racial and gender differences in intelligence has been marked by methodological errors and overgeneralizations by researchers on all sides of the issue. We propose ten principles of design, analysis, and reporting that ought to be considered carefully when doing or evaluating research in this area.     

Social Comparison and Body Image: Attractiveness Comparisons to Models and Peers Among Adolescent Girls and Boys

Relations among body image satisfaction and social comparisons to either same-sex peers or media models were examined in 2 studies of adolescent boys and girls. In the first study, 9th and 10th graders described their conceptions of attractiveness for same- and opposite-sex adolescents. These attractiveness attributes were then used in Study 2 in which 7th- and 10th-grade boys and girls reported on social comparisons to models/celebrities and same-sex peers. Body dissatisfaction was also assessed. The results confirmed that both same-sex peers and models/celebrities were the targets of social comparisons for physical attributes, but comparisons on personal and social attributes were more likely directed toward same-sex peers. For boys and girls, weight comparisons to both peer and model targets were primary correlates of body dissatisfaction. In addition, shape comparisons reported by the girls and facial comparisons endorsed by the boys also related to body dissatisfaction. Gender differences in social comparison indicated that girls reported more social comparisons across targets and attributes. Results are discussed in terms of the role of social comparison and peer context for body image during adolescence.     

Evaluation of the psychometric properties of two forgiveness scales

This study examined the psychometric properties of two forgiveness scales using participants enrolled at a Midwestern Catholic university (N = 328). The Forgiveness Scale is a 15—item Likert-type scale designed to measure forgiveness toward an of-fender. The Forgiveness Likelihood Scale is a 10—item Likert-type scale designed to measure tendency to forgive across situations. Factor analyses revealed that the For-giveness Scale contains two subscales (i.e., Absence of Negative, Presence of Posi-tive) and the Forgiveness Likelihood Scale consists of a single factor. Both scales have adequate internal consistency and test-retest reliability. Both subscales of the Forgiveness Scale were significantly correlated in the expected direction with mea-sures of forgiveness, religiousness, anger, hope, religious well-being, existential well-being, and social desirability. The Forgiveness Likelihood Scale was significantly correlated in the expected direction with measures of forgiveness, religiousness, trait anger, religious well-being, and social desirability. The authors thank Sarah Danko, Anne Hovancsek, Carla Kmett, Jennifer Martin, and Colleen Ryan for their assistance. We kindly request that researchers who use the forgiveness scales evaluated in this study provide us with a summary of their psychometric data for the scales. The idea for creating the Forgiveness Likelihood Scale was based upon the Willingness to Forgive Scale (Hebl & Enright, 1993).     

Religiosity, Spirituality, and the Subjective Quality of African American Men's Friendships: An Exploratory Study

The present study fills a crucial gap in literature surrounding the lives of African American men by exploring factors that shape the quality of these men's friendships. Drawing on data from a sample of 171 African American men, the study examines the relative utility of subjective religiosity, subjective spirituality, advice exchange, and affective sharing as predictors of the level of perceived support from male and female friends. Findings reveal age differences in subjective religiosity, subjective spirituality, and in level of advice and affective exchange in men's same-sex as well as cross-sex friendships. Age differences emerged in men's perceptions of the supportiveness of their friendships with women but not with men. Age was not a predictor of perceived supportiveness of same-sex or cross-sex friendships. Subjective religiosity did not predict support in same-sex or cross-sex friendships. Subjective spirituality positively predicted perceived support in men's same-sex friendships but not in cross-sex friendships. Implications of these findings are discussed.