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161.
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G Gallegos L Salazar M Ortiz W Marquez A Davis S Sanchez D Conner H L Schreiber 《Behavioral and neural biology》1990,53(2):172-188
Three experiments were performed to determine whether apparently minimal disturbances of dams and litters would influence haloperidol-induced akinesia. In Experiment I, Long-Evans hooded rats (a) were left unmanipulated, (b) received nestcage relocation and observation, (c) received nestcage relocation/observation and maternal separation, or (d) received nestcage relocation/observation and pup handling. The male adult offspring received open-field testing and later received forepaw-on-dowel catalepsy testing following saline, morphine (20 mg/kg), or haloperidol (2 mg/kg). In Experiment II, hooded rats received (a) no manipulation, (b) nestcage relocation, (c) maternal separation, or (d) pup handling. At weaning, dams were tested in the open-field. Activity wheel locomotion of the offspring was assessed following saline or haloperidol for 3 days/week for 3 weeks; then, 5 and 7 days later, rats received haloperidol (0.5 mg/kg) and catalepsy testing. In both experiments, manipulations involving the dam reduced the offsprings' haloperidol-induced catalepsy, but, in Experiment II, a history of haloperidol administration distinguished between the effects of nestcage relocation and maternal separation. In Experiment III, Swiss albino mice received (a) no treatment, (b) nestcage relocation and maternal separation, (c) relocation/separation and mild cold stress of pups, (d) relocation/separation and pup handling, or (e) relocation/separation and severe cold stress of pups. Adult male mice received saline or haloperidol (2.5 mg/kg) and inclined grid catalepsy testing. Mice receiving relocation/separation and mice receiving relocation/separation and severe cold stress showed enhanced catalepsy versus control mice. Thus, it was concluded that seemingly innocuous events in infancy can influence the intensity of extrapyramidal side effects of neuroleptics in adulthood. 相似文献
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How do we make causal judgments? Many studies have demonstrated that people are capable causal reasoners, achieving success on tasks from reasoning to categorization to interventions. However, less is known about the mental processes used to achieve such sophisticated judgments. We propose a new process model—the mutation sampler—that models causal judgments as based on a sample of possible states of the causal system generated using the Metropolis–Hastings sampling algorithm. Across a diverse array of tasks and conditions encompassing over 1,700 participants, we found that our model provided a consistently closer fit to participant judgments than standard causal graphical models. In particular, we found that the biases introduced by mutation sampling accounted for people's consistent, predictable errors that the normative model by definition could not. Moreover, using a novel experimental methodology, we found that those biases appeared in the samples that participants explicitly judged to be representative of a causal system. We conclude by advocating sampling methods as plausible process-level accounts of the computations specified by the causal graphical model framework and highlight opportunities for future research to identify not just what reasoners compute when drawing causal inferences, but also how they compute it. 相似文献
164.
Nancy Miodrag Deborah A. Richards J. Paul Fedoroff Shelley L. Watson 《Behavioral sciences & the law》2020,38(2):152-172
Individuals with intellectual disabilities (IDs) – and specifically those with genetic disorders – are more prone to medical and psychological challenges that affect their sexual development, experiences, and fertility. In this review paper we first provide an overview of the biopsychosocial (BPS) model and then explain how the model can guide and improve the assessment and treatment of challenging sexual behaviors by persons with IDs. We discuss two genetic conditions – fragile X syndrome and 22q11.2 deletion syndrome – in case studies, showing how the BPS model can be used to assess and treat the sexual problems of individuals with various types of ID. We conclude with BPS-formulated treatment considerations in three key domains: biomedical treatment (e.g., medication side effects; stopping or changing medications), psychological treatment (e.g., providing psychological therapies), and socio-environmental interventions (e.g., providing socio-sexual education and staff training). Together, these treatment interventions can aid clinicians to prevent and/or treat problematic sexual behaviors of people with IDs. 相似文献
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Playfulness is an individual differences variable at the trait-level. It describes the ability to experience or (re)frame everyday situations as stimulating, interesting, and/or entertaining. Playfulness in adolescents is understudied. We collected self-report data on four facets of playfulness (other-directed, lighthearted, intellectual, and whimsical) in two German-speaking samples of adolescents (N1 = 210, N2 = 270; age range 13–18 years). The facets correlated positively, but to varying degrees with life satisfaction (social life, self, friends) and intrinsic goals. There was no relationship with self-reported school grades and achievement goals (Sample 1). Playfulness in girls was associated with peer-nominated (classmates) bullying behaviors and victimization status (Sample 2). Overall, the findings show that playfulness has an impact on various domains of the life of adolescents. We discuss directions for further research in the field. 相似文献
167.
The relationship between perceived marital satisfaction and early mother-infant interaction was investigated. Seventeen mothers and their three-day-old infants served as subjects. Dyads were observed via a modified time-sampling technique during a hospital feeding session. Then mothers completed a questionnaire concerning their perceptions of the marital relationship. Correlational analyses revealed a significant covariance of positive perceptions of the expressive aspects of the marital relationship and heightened social interaction for mother and infant. An interrelationship was observed between mother-neonate social-visual communication and maternal reports of planned pregnancies, time spent talking with spouse, general ratings of “getting along with spouse,” and positive overall evaluations of the material relationship. Also observed was the interrelationship of mother holding infant away from close bodily contact with reports of decreased love felt toward spouse, less optimal perceptions of ease of emotional expression and spousal interest in maternal daily activities, and less optimal overall ratings of the relationship. Implications of the results and the need for further research are discussed. 相似文献
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We measured driving performance (lane-keeping errors, driving times, and glances away from the road scene) in a video driving simulator for 24 volunteers who each drove alone on a 10.6-km multicurved course while simultaneously placing calls on a mobile phone subscribed to a voice-activated dialing system. Driving performance also was measured for the same distance while participants manually dialed phone numbers and while they drove without dialing. There were 22% fewer lane-keeping errors (p<.01) and 56% fewer glances away from the road scene (p<.01) when they used voice-activated dialing as compared to manual dialing. Significantly longer driving times in both of the dialing conditions as compared to the No Dialing condition are discussed in terms of the hypothesis that drivers decrease driving speed to compensate for the demands of the secondary phone tasks. 相似文献