Improving general intelligence with a nutrient-based pharmacological intervention

Cognitive enhancing substances such as amphetamine and modafinil have become popular in recent years to improve acute cognitive performance particularly in environments in which enhanced cognition or intelligence is required. Nutraceutical nootropics, which are natural substances that have the ability to bring about acute or chronic changes in cognition have also been gaining popularity in a range of settings and applications including the workplace, driving and in the amelioration of age related cognitive decline. Huperzine A, Vinpocetine, Acetyl-l-carnitine, Rhodiola Rosea and Alpha-lipoic Acid are popular nutritional supplements that have shown promising benefits in improving a range of biological (e.g., blood flow, anti-inflammatory, anti-oxidant, and direct neurotransmitter effects) and cognitive processes from in vitro, animal and human clinical research. We report here the first human randomized clinical trial for cognition in which we administer a combination of Huperzine A, Vinpocetine, Acetyl-l-carnitine, R. Rosea and Alpha-lipoic acid (called Ceretrophin) vs placebo. Sixty participants (40 females and 20 males, with a mean age of 45.4 years, SD = 12.6) completed either the odd or even items from the Raven Advanced Progressive Matrices (APM) at baseline and the opposite odd or even items at week 4 after consuming either the combination nootropic or placebo. A significant study visit (time) × treatment condition interaction was found: F (1, 57) = 7.279, p = 0.009, partial η² = .113, with paired samples t-tests revealing a significant improvement in mean APM score from baseline to retest (week 4) (t(34) = ? 4.045, p < .001) for the Ceretrophin? group. Improvements in APM scores could be attributed to the active intervention over the placebo, indicating that the treatment improved general intelligence. Implications for improving our understanding of the biological basis of intelligence and pharmacologically improving human cognition are discussed.     

The relationship between psychopathy and impulsivity: A multi-impulsivity measurement approach

Psychopathy is a serious personality disorder of which impulsivity is a key component. However, impulsivity is a multidimensional construct, with multiple approaches to measurement, and different measures may be differentially implicated in psychopathy. This study investigated the relationship between psychopathy as assessed by the Psychopathic Personality Inventory-Revised (PPI-R; Lilienfeld & Widows, 2005), a personality measure of impulsivity (Barratt Impulsiveness Scale-11), and four behavioural measures of impulsivity (GoStop Impulsivity Paradigm, Two Choice Impulsivity Paradigm, Delay Discounting Task, Iowa Gambling Task). A nonclinical sample (N = 80) was recruited from the local community to advance understanding of psychopathy in non-incarcerated samples. The results indicated that the personality measure of impulsivity was strongly correlated with the PPI-R, while the behavioural measures were either not correlated or only weakly correlated with the PPI-R. The results are discussed in terms of the multifaceted nature of impulsivity and the need for the further development of behavioural measures of impulsivity, given their importance in clinical assessment and intervention.     

Memory for details with self-referencing

Self-referencing benefits item memory, but little is known about the ways in which referencing the self affects memory for details. Experiment 1 assessed whether the effects of self-referencing operate only at the item, or general, level or whether they also enhance memory for specific visual details of objects. Participants incidentally encoded objects by making judgements in reference to the self, a close other (one's mother), or a familiar other (Bill Clinton). Results indicate that referencing the self or a close other enhances both specific and general memory. Experiments 2 and 3 assessed verbal memory for source in a task that relied on distinguishing between different mental operations (internal sources). The results indicate that self-referencing disproportionately enhances source memory, relative to conditions referencing other people, semantic, or perceptual information. We conclude that self-referencing not only enhances specific memory for both visual and verbal information, but can also disproportionately improve memory for specific internal source details.     

When partner caring leads to sharing: Partner responsiveness increases expressivity, but only for individuals with low self-esteem

Two studies examined whether perceiving a partner as responsive leads people to be more expressive with that partner, and whether the effects of perceived partner responsiveness on expressivity are moderated by self-esteem. In Study 1, female undergraduates with high or low self-esteem disclosed to a fictitious partner about a sad event. Participants either received an understanding, caring, and validating written response from their ostensible partner or did not receive a response. In Study 2, participants wrote an email, supposedly to another participant, about a sad event and received either a highly responsive or a non-responsive email response. In both studies, partner responsiveness increased expressivity among individuals with low self-esteem but not among individuals with high self-esteem. These results provide the first experimental evidence for Reis and Shaver's (1988) theorizing about responsiveness and self-disclosure.     

Identification of cognitive profiles among women considering BRCA1/2 testing through the utilisation of cluster analytic techniques

Based on the cognitive-social health information processing model, we identified cognitive profiles of women at risk for breast and ovarian cancer. Prior to genetic counselling, participants (N = 171) completed a study questionnaire concerning their cognitive and affective responses to being at genetic risk. Using cluster analysis, four cognitive profiles were generated: (a) high perceived risk/low coping; (b) low value of screening/high expectancy of cancer; (c) moderate perceived risk/moderate efficacy of prevention/low informativeness of test result; and (d) high efficacy of prevention/high coping. The majority of women in Clusters One, Two and Three had no personal history of cancer, whereas Cluster Four consisted almost entirely of women affected with cancer. Women in Cluster One had the highest number of affected relatives and experienced higher levels of distress than women in the other three clusters. These results highlight the need to consider the psychological profile of women undergoing genetic testing when designing counselling interventions and messages.     

Temporal patterns of anxious and depressed mood in generalized anxiety disorder: a daily diary study

Research suggests that anxiety disorders tend to temporally precede depressive disorders, a finding potentially relevant to understanding comorbidity. The current study used diary methods to determine whether daily anxious mood also temporally precedes daily depressed mood. 55 participants with generalized anxiety disorder (GAD) and history of depressive symptoms completed a 21-day daily diary tracking anxious and depressed mood. Daily anxious and depressed moods were concurrently associated. Daily anxious mood predicted later depressed mood at a variety of time lags, with significance peaking at a two-day lag. Depressed mood generally did not predict later anxious mood. Results suggest that the temporal antecedence of anxiety over depression extends to daily symptoms in GAD. Implications for the refinement of comorbidity models, including causal theories, are discussed.     

Influences of lexical tone and pitch on word recognition in bilingual infants

Infants' abilities to discriminate native and non-native phonemes have been extensively investigated in monolingual learners, demonstrating a transition from language-general to language-specific sensitivities over the first year after birth. However, these studies have mostly been limited to the study of vowels and consonants in monolingual learners. There is relatively little research on other types of phonetic segments, such as lexical tone, even though tone languages are very well represented across languages of the world. The goal of the present study is to investigate how Mandarin Chinese-English bilingual learners contend with non-phonemic pitch variation in English spoken word recognition. This is contrasted with their treatment of phonemic changes in lexical tone in Mandarin spoken word recognition. The experimental design was cross-sectional and three age-groups were sampled (7.5months, 9months and 11months). Results demonstrated limited generalization abilities at 7.5months, where infants only recognized words in English when matched in pitch and words in Mandarin that were matched in tone. At 9months, infants recognized words in Mandarin Chinese that matched in tone, but also falsely recognized words that contrasted in tone. At this age, infants also recognized English words whether they were matched or mismatched in pitch. By 11months, infants correctly recognized pitch-matched and - mismatched words in English but only recognized tonal matches in Mandarin Chinese.     

Managing motivational conflict: How self-esteem and executive resources influence self-regulatory responses to risk

This article explores how self-esteem and executive resources interact to determine responses to motivational conflict. One correlational and 3 experimental studies investigated the hypothesis that high and low self-esteem people undertake different self-regulatory strategies in "risky" situations that afford opportunity to pursue competing goals and that carrying out these strategies requires executive resources. When such resources are available, high self-esteem people respond to risk by prioritizing and pursuing approach goals, whereas low self-esteem people prioritize avoidance goals. However, self-esteem does not influence responses to risk when executive resources are impaired. In these studies, risk was operationalized by exposing participants to a relationship threat (Studies 1 and 2), by using participants' self-reported marital conflict (Study 3), and by threatening academic competence (Study 4). Executive resources were operationalized as cognitive load (Studies 1 and 2), working memory capacity (Study 3), and resource depletion (Study 4). When executive resources were ample, high self-esteem people responded to interpersonal risk by making more positive relationship evaluations (Studies 1, 2, and 3) and making more risky social comparisons following a personal failure (Study 4) than did low self-esteem people. Self-esteem did not predict participants' responses when executive resources were impaired or when risk was absent. The regulatory function of self-esteem may be more resource-dependent than has been previously theorized. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

The Influence of Families on Early Adolescent School Connectedness: Evidence That This Association Varies with Adolescent Involvement in Peer Drinking Networks

School connectedness is central to the long term well-being of adolescents, and high quality parent–child relationships facilitate school connectedness. This study examined the extent to which family relationship quality is associated with the school connectedness of pre- and early teenagers, and how this association varies with adolescent involvement in peer drinking networks. The sample consisted of 7,372 10–14 year olds recruited from 231 schools in 30 Australian communities. Participants completed the Communities that Care youth survey. A multi-level model of school connectedness was used, with a random term for school-level variation. Key independent variables included family relationship quality, peer drinking networks, and school grade. Control variables included child gender, sensation seeking, depression, child alcohol use, parent education, and language spoken at home. For grade 6 students, the association of family relationship quality and school connectedness was lower when peer drinking networks were present, and this effect was nonsignificant for older (grade 8) students. Post hoc analyses indicated that the effect for family relationship quality on school connectedness was nonsignificant when adolescents in grade 6 reported that the majority of friends consumed alcohol. The results point to the importance of family-school partnerships in early intervention and prevention.     

Statistical learning is related to reading ability in children and adults

There is little empirical evidence showing a direct link between a capacity for statistical learning (SL) and proficiency with natural language. Moreover, discussion of the role of SL in language acquisition has seldom focused on literacy development. Our study addressed these issues by investigating the relationship between SL and reading ability in typically developing children and healthy adults. We tested SL using visually presented stimuli within a triplet learning paradigm and examined reading ability by administering the Wide Range Achievement Test (WRAT-4; Wilkinson & Robertson, 2006). A total of 38 typically developing children (mean age of 9;5 years, range 6;4-12;5) and 37 healthy adults (mean age of 21 years, range 18-34) were assessed. In children, SL was significantly related to reading ability. Importantly, this relationship was independent of grade and also age. The adult data, too, revealed that SL was significantly related to reading ability. A regression analysis of the combined child and adult data revealed that SL accounted for a unique amount of variance in reading ability, after age and attention had been taken into consideration. For the first time, this study provides empirical evidence that a capacity for more effective SL is related to higher reading ability in the general population.