Timing recalibration in childhood Tourette syndrome associated with persistent pimozide treatment

In this study, we have tested the effects of the dopamine D₂ receptor blocker pimozide on timing performance in patients with Tourette syndrome (TS). Nine children with TS were tested off‐medication and following 3 months of daily treatment with pimozide. Subjects completed a time reproduction and a time production task using supra‐second temporal intervals. We show that pimozide improves motor timing performance by reducing the patients' variability in reproducing the duration of visual stimuli. On the other hand, this medication has no effect on the reproduction accuracy and on both variability and accuracy of the performance on the time production task. Our results suggest that pimozide might have improved motor timing variability as a result of its beneficial side effect on endogenous dopamine levels (i.e., normalization).     

Global subjective memorability and the strength-based mirror effect in recognition memory

Between-list manipulations of memory strength through repetition commonly generate a mirror effect, with more hits and fewer false alarms for strengthened items. However, this pattern is rarely seen with within-list manipulations of strength. In three experiments, we investigated the conditions under which a within-list mirror effect of strength (items presented once or thrice) is observed. In Experiments 1 and 2, we indirectly manipulated the overall subjective memorability of the studied lists by varying the proportion of nonwords. A within-list mirror effect was observed only in Experiment 2, in which a higher proportion of nonwords was presented in the study list. In Experiment 3, the presentation duration for each item (0.5 vs. 3 sec) was manipulated between groups with the purpose of affecting subjective memorability. A within-list mirror effect was observed only for the short presentation durations. Thus, across three experiments, we found the within-list mirror effect only under conditions of poor overall subjective memorability. We propose that when the overall subjective memorability is low, people switch their response strategy on an item-by-item basis and that this generates the observed mirror effect.     

Selective impairment of living things and musical instruments on a verbal 'Semantic Knowledge Questionnaire' in a case of apperceptive visual agnosia

Semantic memory was investigated in a patient (MR) affected by a severe apperceptive visual agnosia, due to an ischemic cerebral lesion, bilaterally affecting the infero-mesial parts of the temporo-occipital cortices. The study was made by means of a Semantic Knowledge Questionnaire (Laiacona, Barbarotto, Trivelli, & Capitani, 1993), which takes separately into account four categories of living beings (animals, fruits, vegetables and body parts) and of artefacts (furniture, tools, vehicles and musical instruments), does not require a visual analysis and allows to distinguish errors concerning super-ordinate categorization, perceptual features and functional/encyclopedic knowledge. When the total number of errors obtained on all the categories of living and non-living beings was considered, a non-significant trend toward a higher number of errors in living stimuli was observed. This difference, however, became significant when body parts and musical instruments were excluded from the analysis. Furthermore, the number of errors obtained on the musical instruments was similar to that obtained on the living categories of animals, fruits and vegetables and significantly higher of that obtained in the other artefact categories. This difference was still significant when familiarity, frequency of use and prototypicality of each stimulus entered into a logistic regression analysis. On the other hand, a separate analysis of errors obtained on questions exploring super-ordinate categorization, perceptual features and functional/encyclopedic attributes showed that the differences between living and non-living stimuli and between musical instruments and other artefact categories were mainly due to errors obtained on questions exploring perceptual features. All these data are at variance with the 'domains of knowledge' hypothesis', which assumes that the breakdown of different categories of living and non-living things respects the distinction between biological entities and artefacts and support the models assuming that 'category-specific semantic disorders' are the by-product of the differential weighting that visual-perceptual and functional (or action-related) attributes have in the construction of different biological and artefacts categories.     

Intraoperative conversion to open technique: is informed consent implied?

This case raises issues regarding the anesthesia and surgical components of preoperative informed consent and the differing views of anesthesiologists and surgeons with regards to informed consent, in the context of conversion to open surgery from a minimally invasive approach.     

Twenty-four hours of total sleep deprivation selectively impairs attentional networks

Performance decrements after sleep loss have been extensively studied and are usually attributed to generic attentional deficits. This claim, however, is based on the view of attention as a unitary construct, despite evidence that it should be considered a multidimensional cognitive ability. The aim of the present study was to evaluate the impact of one night of sleep deprivation on the efficiency of three attentional networks, defined by Posner and Raichle (1994) in anatomical and functional terms, as alerting, orienting, and executive control. Thirty participants performed the Attention Network Test at 9:00 a.m. following two different sleep conditions: baseline (a normal night of sleep) and deprivation (24 hrs of wakefulness). Results showed an overall slowing in reaction times and a significant decrease in accuracy after sleep deprivation. Sleep deprivation selectively affected the three attentional networks, given that only executive control efficacy significantly decreased after sleep deprivation. By contrast, phasic alerting and orienting showed no differences in the two sleep conditions. Thus, performance deficits following sleep deprivation do not reflect global attentional deficits.     

Gay and Lesbian Couples in Italy: Comparisons with Heterosexual Couples

Assessing couple relationships across diverse languages and cultures has important implications for both clinical intervention and prevention. This is especially true for nontraditional relationships potentially subject to various expressions of negative societal evaluation or bias. Few empirically validated measures of relationship functioning have been developed for cross‐cultural applications, and none have been examined for their psychometric sufficiency for evaluating same‐sex couples across different languages and cultures. The current study examined the psychometric properties of an Italian translation of the Marital Satisfaction Inventory – Revised (MSI‐R), a 150‐item 13‐scale measure of couple relationship functioning, for its use in assessing the intimate relationships of gay and lesbian couples in Italy. Results for these couples were compared to data from heterosexual married and unmarried cohabiting couples from the same geographical region, as well as to previously published data for gay, lesbian, and unmarried heterosexual couples from the United States. Findings suggest that, despite unique societal pressures confronting Italian same‐sex couples, these relationships appear resilient and fare well both overall and in specific domains of functioning compared to heterosexual couples both in Italy and the United States.     

Homeostatic Property Cluster Theory without Homeostatic Mechanisms: Two Recent Attempts and their Costs

Journal for General Philosophy of Science - The homeostatic property cluster theory (HPC) is widely influential for its ability to account for many natural-kind terms in the life sciences. However,...     

Exclusive and inclusive protest in Europe: Investigating values,support for democracy,and life conditions

Dissatisfaction with the economic situation and perceived governmental inefficacy in regard to the financial crisis has spawned a widespread feeling of political distrust across Europe. This distrust has been translated into protests against institutional authority that aims at either expanding democratic procedures or supporting xenophobic and populist measures. This research uses European Social Survey data to compare exclusive and inclusive protesters with regard to a number of personal and social values, attitudes toward democratic principles, and different life conditions and socio‐economic resources. It also considers contextual factors to investigate how different protesters' profiles are interwoven with socio‐economic conditions. The results of a multilevel latent profile analysis show that exclusive and inclusive protesters, despite sharing similar levels of political distrust, differ with regard to key values and political attitudes, and these differences are related to individual and collective living conditions. We argue that unfavourable living conditions play a non‐negligible role in increasing the probability of easy (i.e., populist) scapegoat political attitudes. Further support for this hypothesis is provided by the cross‐country analysis, which shows that higher levels of exclusive protest are present in countries that were characterized by worse living conditions before the economic crisis.     

Memory bias for negative emotional words in recognition memory is driven by effects of category membership

Recognition memory studies often find that emotional items are more likely than neutral items to be labelled as studied. Previous work suggests this bias is driven by increased memory strength/familiarity for emotional items. We explored strength and bias interpretations of this effect with the conjecture that emotional stimuli might seem more familiar because they share features with studied items from the same category. Categorical effects were manipulated in a recognition task by presenting lists with a small, medium or large proportion of emotional words. The liberal memory bias for emotional words was only observed when a medium or large proportion of categorised words were presented in the lists. Similar, though weaker, effects were observed with categorised words that were not emotional (animal names). These results suggest that liberal memory bias for emotional items may be largely driven by effects of category membership.     

A place for nouns and a place for verbs? A critical review of neurocognitive data on grammatical-class effects

It is generally held that noun processing is specifically sub-served by temporal areas, while the neural underpinnings of verb processing are located in the frontal lobe. However, this view is now challenged by a significant body of evidence accumulated over the years. Moreover, the results obtained so far on the neural implementation of noun and verb processing appear to be quite inconsistent. The present review briefly describes and critically re-considers the anatomo-correlative, neuroimaging, MEG, TMS and cortical stimulation studies on nouns and verbs with the aim of assessing the consistency of their results, particularly within techniques. The paper also addresses the question as to whether the inconsistency of the data could be due to the variety of the tasks used. However, it emerged that neither the different investigation techniques used nor the different cognitive tasks employed fully explain the variability of the data. In the final section we thus suggest that the main reason for the emergence of inconsistent data in this field is that the cerebral circuits underlying noun and verb processing are not spatially segregated, at least for the spatial resolution currently used in most neuroimaging studies.