Religion and the use of animals in research: some first thoughts

Religious traditions can be drawn on in a number of ways to illuminate discussions of the moral standing of animals and the ethical use of animals in scientific research. I begin with some general comments about relevant points in the history of major religions. I then briefly describe American civil religion, including the cult of health, and its relation to scientific research. Finally, I offer a critique of American civil religion from a Christian perspective.     

Lateralized Changes in Regional Cerebral Blood Flow during Performance of Verbal and Facial Recognition Tasks: Correlations with Performance and “Effort”

Functional neuroimaging has been used to investigate neural substrates of mnemonic processes, and cerebral blood flow (CBF) measures have been sensitive to activation with memory tasks. Studies of memory with two-dimensional¹³³Xenon clearance techniques found that word and face recognition tasks produced contralateral CBF changes in mid-temporal cortical regions. This study replicated the activation paradigm, expanding to the three-dimensional resolution of positron emission tomography (PET). Word and face recognition, and a control baseline task were administered to 19 healthy right-handed volunteers (11 men, 8 women) during successive 10 min PET¹⁵O-water measures of CBF. Quantitative CBF rates were calculated with the arterial input function and the equilibrium model. Redistributions of blood flow were compared across tasks using both absolute and relative (region/whole brain) CBF.Replicating the¹³³Xenon clearance findings, CBF was “appropriately” lateralized during task performance (left–right for words > left–right for faces) in the mid-temporal region. Contrary to predictions, the recognition tasks did not activate expected mesolimbic or prefrontal areas. The task-induced CBF changes also correlated with performance. Bilateral CBF in mid-temporal and parahippocampal gyrus regions of interest correlated with the ability to correctly identify word targets (sensitivity). Left-lateralized CBF in the amygdala and hippocampus correlated with better word sensitivity as well as specificity (ability to correctly reject foils). Complementally, right-lateralized CBF in the parahippocampal gyrus correlated with better face specificity performance. In addition, left-lateralized CBF in the amygdala and right-lateralized CBF in the parahippocampal gyrus and hippocampus correlated with “mental effort” indices (task performance relative to basal ability) for word and face memory tasks, respectively. Thus, whereas this recognition task showed the expected lateralized increase in the mid-temporal region and not in frontal and limbic areas, lateralized activation in some of these areas was associated with better performance. Exploratory analyses on other regions showed lateralized changes in one additional temporal region, the occipital-temporal, and several limbic regions.     

Developing local lifelong guidance strategies

The background, rationale, methodology and outcomes of a project on developing local lifelong guidance strategies in four areas are outlined. The main components of the strategies developed in the four areas are analysed, and a number of issues relating to the process of strategy development are addressed. Much of the lack of coherence at local level stems from lack of coherence at national policy level: implications for national policy are examined. Finally, implications for parallel work in other localities are explored.     

The specific action of different personality risk factors on cancer of the breast, cervix, corpus uteri and other types of cancer: A prospective investigation

We report the results of a prospective study of a random sample of 1353 elderly but healthy men and women who were followed up for a period of 10 yr, when mortality and cause of death were ascertained. Overall results have been reported elsewhere for mortality from cancer, coronary heart disease and other causes; here we are concerned with the personality factors predicting breast cancer, cervical cancer, cancer of the corpus uteri specifically, as well as other types of cancer in women. Ten specific hypotheses were tested, using specially constructed questionnaires for the purpose, and for most of these statistically significant support was obtained. The results justify belief that specific types of cancer may be related to specific stress/personality factors.     

Book reviews

Socializing Epistemology: The Social Dimensions of Knowledge, Frederick F. Schmitt, Ed., 1994. Lanham, MD, Rowman and Littlefield, ix + 315 pp., US$22.95, ISBN: 0847679594

A Dynamic Systems Approach to the Development of Cognition and Action, Esther Thelen & Linda B. Smith. Cambridge, MA, MIT Press, xxii + 376 pp., $50, ISBN 0–262–20095–3 cloth

From Kant to Hilbert: A Source Book in the Foundations of Mathematics, William B. Ewald, Ed., 1996. Oxford, Oxford University Press. xviii+ 1340 pp., £195.00, two volumes, ISBN 0–19–853271–7 (the set)     

Guest editors'' commentary: Japanese socialization research in review

This focus section has presented Japanese research on a variety of socialization agents and contexts, including mothering, fathering, peers and multiple-caretakers in families and institutions. The reader is encouraged to compare the papers, discover the theoretical and applied implications of each study for child development in the reader's own culture, and to pursue collaborations with the outstanding young Japanese contributors. We conclude with brief comments on each of the five articles, discussing their limitations, most significant findings, theoretical importance, and implications for subsequent research.     

Abstraction Processes in Artificial Grammar Learning

Four experiments explored the extent to which abstract knowledge may underlie subjects' performance when asked to judge the grammaticality of letter strings generated from an artificial grammar. In Experiments 1 and 2 subjects studied grammatical strings instantiated with one set of letters and were then tested on grammatical and ungrammatical strings formed either from the same or a changedletter-set.Evenwith a change ofletter-set, subjects were found to be sensitive to a variety of violations of the grammar. In Experiments 3 and 4, the critical manipulation involved the way in which the training strings were studied: an incidental learning procedure was used for some subjects, and others engaged in an explicit code-breaking task to try to learn the rules of the grammar. When strings were generated from a biconditional (Experiment 4) but not from a standard finite-state grammar (Experiment 3), grammaticality judgements for test strings were independent of their surface similarity to specific studied strings. Overall, the results suggest that transfer in this simple memory task is mediated at least to some extent by abstract knowledge.     

New career, old problem: Learning from 'things gone wrong'

Escalating pressures for self-development require people of all ages to possess increasingly sophisticated levels of self-knowledge. From a career planning perspective, this means knowing more about one's strengths and weaknesses. Although some people acquire knowledge about themselves from instruments and assessment processes, many more look to their personal histories, including career histories, for evidence confirming competence. Research examining failures and setbacks recalled by a diverse sample of artists, athletes and business people is reported. It is concluded that people often hold distorted interpretations of life's disappointments, underscoring the need for informed guidance