Treatment of bipolar depression

Bipolar disorder is underdiagnosed and often mistaken for unipolar depression. Bipolar patients spend 33% of their time in a state of depression compared to 11% of time spent in a manic state. Duration of time depressed and severity of depression are associated with increased risk for suicide, which occurs in 10% to 20% of bipolar patients. Antidepressants are increasingly being used as adjuncts in the depressed phase of bipolar disorder, although they provide a moderate risk for switch into mania. Lithium and some antiepileptics and atypical antipsychotics have shown antidepressant effects in the treatment of bipolar disorder. Other adjuncts for treatment-refractory patients include monoamine oxidase inhibitors and electroconvulsive therapy.     

Early maternal availability and prefrontal correlates of reward-related memory

Early emotional experiences affect developing brain systems that subsequently mediate adult learning and memory in rodents. Here we test for similar effects in squirrel monkeys (Saimiri sciureus) four years after disruptions in early maternal availability. These conditions were previously shown to generate differences in emotional behavior, hypothalamic-pituitary-adrenal stress physiology, and right ventral medial prefrontal volumes determined in adulthood by magnetic resonance imaging. This report identifies in the same monkeys variability in reward-related memory on tests with a spatial reversal. Adult monkeys that more often selected locations repeatedly rewarded before each reversal had larger right ventral medial prefrontal volumes, but not hippocampal nor dorsolateral prefrontal volumes on the left or right brain side. Differences in performance were also discerned after each spatial reversal. These findings indicate that maternal availability alters developing ventral medial prefrontal brain regions involved in reward-related memory.     

British female academics and comparative psychology: attempts to establish a research niche in the early 20th century

Why was there a preponderance of women engaged in laboratory-based studies of animal behavior in Britain in the early years of the 20th century? As a new experimental subject with recently neglected potential, animal psychology then represented an opportunity for women to make further inroads into academic science. Because the study of psychology before World War I offered negligible professional opportunities for the application of the subject, the intake of students was restricted. Perhaps this encouraged academic access to it by aspiring female scientists who felt that career prospects, uncertain and socially unexpected of them in any case, were worth chancing for greater long-term rewards. The academic circumstances and contributions of 3 British female pioneers in experimental comparative psychology are discussed.     

The reliability and stability of verbal working memory measures

The psychometric properties of several commonly used verbal working memory measures were assessed. One hundred thirty-nine individuals in five age groups (18–30, 50–59, 60–69, 70–79, and 80+ years) were tested twice (Time I and Time II) on seven working memory span measures (alphabet span, backward digit span, missing digit span, subtract 2 span, running item span, and sentence span for syntactically simple and complex sentences), with an interval of approximately 6 weeks between testing. There were significant effects of age on all but two of the tasks. All the measures had adequate internal consistency. Correlations between performances at Time I and Time II were significant for all the tasks, other than the missing digit span task. The magnitude of the correlations was similar across the age groups and ranged from .52 to .81. Classification of subjects into discrete memory span groups on the basis of a single measure was highly inconsistent across testing sessions and tasks. Classification into upper and lower quartiles was more stable than using a cutoff score for group membership or than classification into high-, medium-, and low-span groups. Correlational analyses showed that there was a moderate relationship between performances on many of the span tasks. Confirmatory factor analysis suggested that six of the seven tasks reflected a common factor. Both test—retest reliability and stability of classification improved when a composite measure reflecting performance on several tasks was used.     

Scaling techniques for modeling directional knowledge

A common way for researchers to model or graphically portray spatial knowledge of a large environment is by applying multidimensional scaling (MDS) to a set of pairwise distance estimations. We introduce two MDS-like techniques that incorporate people’s knowledge of directions instead of (or in addition to) their knowledge of distances. Maps of a familiar environment derived from these procedures were more accurate and were rated by participants as being more accurate than those derived from nonmetric MDS. By incorporating people’s relatively accurate knowledge of directions, these methods offer spatial cognition researchers and behavioral geographers a sharper analytical tool than MDS for studying cognitive maps.     

Using the Observer to analyze learning in virtual worlds

In this study, we describe and analyze the ways in which high school students explored a virtual solar system (VSS). VSS is a nonimmersive virtual environment that affords visual manipulations of space by altering its frame of reference. The Observer software was used to code and analyze the participants’ real-time free-exploration task. Two basic behaviors were identified across participants: establishing several home bases, and shifting between a still mode and a dynamic mode. Moreover, three overall exploration patterns emerged: thebutterfly pattern represents a superficial mode of learning; thebee pattern represents an in-depth mode of studying the various celestial objects; and theeagle pattern represents a global approach of studying the complex system. This virtual reality environment promises to provide a setting in which to further study consistent patterns and individual differences in exploration strategies.     

Homelessness

The author, acknowledging the reality of homeless persons in most communities, explores the meanings and dynamics of homelessness, and the need to recognize the variety of participants needing to be recognized in appreciating the complexity of this segment of society. He raises the issue of how pastoral caregivers become involved in providing authentic care to this sub-culture and offers examples from his own experiences as a volunteer chaplain in the Salvation Army Corps.     

The influence of language exposure on lexical and syntactic language processing

Previous literature has argued that proficient bilingual speakers often demonstrate monolingual-equivalent structural processing of language (e.g., the processing of structural ambiguities; Frenck-Mestre, 2002). In this paper, we explore this thesis further via on-line examination of the processing of syntactically complex structures with three populations: those who classify as monolingual native English speaker (MNES), those who classify as non-native English speakers (NNES), and those who calssify as bilingual native English speakers (BNES). On-line measures of processing of object-relative constructions demonstrated that both NNES and BNES have different patterns of performance as compared to MNES. Further, NNES and BNES speakers perform differently from one another in such processing. The study also examines the activation of lexical information in biasing contexts, and suggests that different processes are at work in the different type of bilinguals examined here. The nature of these differences and the implications for developing sensitive models of on-line language comprehension are developed and discussed.