Role of a striatal slowly inactivating potassium current in short-term facilitation of corticostriatal inputs: a computer simulation study

Striatal output neurons (SONs) integrate glutamatergic synaptic inputs originating from the cerebral cortex. In vivo electrophysiological data have shown that a prior depolarization of SONs induced a short-term (相似文献   

Mechanisms and the current state of transcranial magnetic stimulation

Transcranial magnetic stimulation (TMS) is unique among the current brain stimulation techniques because it is relatively non-invasive. TMS markedly differs from vagus nerve stimulation, deep brain stimulation and magnetic seizure therapy, all of which require either an implanted prosthesis or general anesthesia, or both. Since its rebirth in its modern form in 1985, TMS has already shown potential usefulness in at least three important domains-as a basic neuroscience research instrument, as a potential clinical diagnostic tool, and as a therapy for several different neuropsychiatric conditions. The TMS scientific literature has now expanded beyond what a single summary article can adequately cover. This review highlights several new developments in combining TMS with functional brain imaging, using TMS as a psychiatric therapy, potentially using TMS to enhance performance, and finally recent advances in the core technology of TMS. TMS' ability to non-invasively and focally stimulate the brain of an awake human is proving to be a most important development for neuroscience in general, and neuropsychiatry in particular.     

The importance of degree versus type of maltreatment: a cluster analysis of child abuse types

The author conducted secondary data analysis of 3 previously reported studies (D. J. Higgins & M.P. McCabe, 1998, 2000b, 2003) to examine whether respondents are best classified according to their experience of separate maltreatment types (sexual abuse, physical abuse, psychological maltreatment, neglect, and witnessing family violence) or whether their experience reflects a single unifying concept: child maltreatment. The author conducted a cluster analysis of the combined dataset followed by a confirmatory discriminant function analysis. Finally, the differences in psychological adjustment between those classified into the 3 different clusters were examined as a test of the 3-cluster solution. The best cluster analysis solution grouped individuals according to the degree to which maltreatment behaviors were reported. Individuals classified into the high maltreatment cluster had significantly more adjustment problems than those in either the moderate or the low maltreatment clusters. The results showed that it may be more meaningful to talk about the degree of maltreatment (frequency and/or severity) experienced by the child rather than about the type.     

Humility attenuates negative attitudes and behaviors toward religious out-group members

Humility is marked by the regulation of selfish impulses for the sake of others, including holding a modest view of one’s beliefs (and their relative strengths and weaknesses). In three studies, we evaluated the extent to which humility attenuates negative attitudes, behavioral intentions, and behaviors toward religious out-group members. In Study 1 (N = 159), humility regarding religious beliefs was associated with positive attitudes toward religiously different individuals. In Study 2 (N = 149), relational and intellectual humility were associated with less aggressive behavioral intentions in a hypothetical situation in which their cherished beliefs were criticized. In Study 3 (N = 62), participants implicitly primed with humility administered significantly less hot sauce (a behavioral measure of aggression) to a religious out-group member who criticized their cherished views relative to participants in the neutral prime condition. We highlight the importance of humility in promoting positive attitudes and behaviors toward religious out-group members.     

Perfectionism and psychological distress: evidence of the mediating effects of rumination

Three studies investigated the role of ruminative tendencies in mediating the effects of multidimensional perfectionism (Hewitt & Flett, 1991) on psychological distress. Study 1 (Sample 1, N = 279; Sample 2, N = 224) and Study 2 (N = 205) found evidence, cross‐sectionally and prospectively, that brooding ruminative response style either fully or partially mediated the effects of socially prescribed and self‐oriented perfectionism on psychological distress, depression and hopelessness levels. In addition, Study 3 (N = 163) confirmed these mediation effects for socially prescribed perfectionism in relation to depression and hopelessness, 2 months later, after initial levels of distress were controlled. Overall, these findings provide evidence that brooding ruminative response style is an important mechanism that can explain, in part, the relationship between perfectionism and distress. Copyright © 2006 John Wiley & Sons, Ltd.     

Relations of low frustration tolerance beliefs with stress, depression, and anxiety in young adolescents

Young adolescents (N=144; 66 boys, 78 girls), ages 12 to 14 years (M=12.2, SD=.8), who reported lower scores on the Low Frustration Tolerance Beliefs Instrument had higher scores on the Perceived Stress Scale and the Profile of Mood States Subscales of Depression and Anxiety.     

Executive working memory load induces inattentional blindness

When attention is engaged in a task, unexpected events in the visual scene may go undetected, a phenomenon known as inattentional blindness (IB). At what stage of information processing must attention be engaged for IB to occur? Although manipulations that tax visuospatial attention can induce IB, the evidence is more equivocal for tasks that engage attention at late, central stages of information processing. Here, we tested whether IB can be specifically induced by central executive processes. An unexpected visual stimulus was presented during the retention interval of a working memory task that involved either simply maintaining verbal material or rearranging the material into alphabetical order. The unexpected stimulus was more likely to be missed during manipulation than during simple maintenance of the verbal information. Thus, the engagement of executive processes impairs the ability to detect unexpected, task-irrelevant stimuli, suggesting that IB can result from central, amodal stages of processing.     

WAR, WOMEN, AND POLITICAL WISDOM

One of the most perceptive and ambidextrous social commentators of our day, Augustinian scholar Jean Bethke Elshtain furnishes in ever fresh ways through her writings a bridge between the ancient and the modern, between politics and ethics, between timeless moral wisdom and cultural sensitivity. To read Elshtain seriously is to take the study of culture as well as the “permanent things” seriously. But Elshtain is no mere moralist. Neither is she content solely to dwell in the domain of the theoretical. For it is Elshtain the citizen—the creatively engaged and contributing citizen—whom the reader encounters on virtually every page of her writings. But reader beware: Elshtain does not shy away from controversy. At the same time, she is anything but a controversialist. In the essay that follows, several prominent themes that emerge from Elstain's writings—civic responsibility, justice, gender, and war—are considered afresh. Whether one agrees with her positions or not, one is forced to confess in the end that she cares deeply about the common good. And this alone makes her required reading for any engaged citizen of the republic.