Pediatric Predispositional Genetic Risk Communication: Potential Utility for Prevention and Control of Melanoma Risk as an Exemplar

Predispositional genetic testing among minor children is intensely debated due to the potential benefits and harms of providing this type of genetic information to children and their families. Existing guidelines on pediatric genetic testing state that predispositional testing could be appropriate for minors if preventive services exist that mitigate children’s risk for or severity of the health condition in question. We use the example of hereditary melanoma to illustrate the rationale for and potential application of genetic risk communication for an adult-onset cancer to a pediatric population where childhood behaviors may reduce risk of disease later in life. We draw from the adult melanoma genetic risk communication and pediatric health behavior change literatures to suggest ways in which genetic test reporting and complementary education could be delivered to children who carry a hereditary risk for melanoma and their families in order to foster children’s engagement in melanoma preventive behaviors. Genetic discoveries will continue to yield new opportunities to provide predispositional genetic risk information to unaffected individuals, including children, and could be delivered within programs that provide personalized and translational approaches to cancer prevention.     

Distorted body representations are robust to differences in experimental instructions

Several recent reports have shown that even healthy adults maintain highly distorted representations of the size and shape of their body. These distortions have been shown to be highly consistent across different study designs and dependent measures. However, previous studies have found that visual judgments of size can be modulated by the experimental instructions used, for example, by asking for judgments of the participant’s subjective experience of stimulus size (i.e., apparent instructions) versus judgments of actual stimulus properties (i.e., objective instructions). Previous studies investigating internal body representations have relied exclusively on ‘apparent’ instructions. Here, we investigated whether apparent versus objective instructions modulate findings of distorted body representations underlying position sense (Exp. 1), tactile distance perception (Exp. 2), as well as the conscious body image (Exp. 3). Our results replicate the characteristic distortions previously reported for each of these tasks and further show that these distortions are not affected by instruction type (i.e., apparent vs. objective). These results show that the distortions measured with these paradigms are robust to differences in instructions and do not reflect a dissociation between perception and belief.     

Preliminary evidence that the limbal ring influences facial attractiveness

The limbal ring of the eye appears as a dark annulus where the iris meets the sclera. Both width and opacity of the limbal ring are influenced by iris pigmentation and optical properties of the region. With age the limbal ring becomes less prominent, making it a probabilistic indicator of youth and health. This raises the question: Are judgments of facial attractiveness sensitive to this signal in a potentially adaptive way? Here we show that the answer is yes. For male and female observers, both male and female faces with a dark and distinct limbal ring are rated as more attractive than otherwise identical faces with no limbal ring. This result is observed not just for upright faces but also for inverted faces, suggesting that the limbal ring is processed primarily as a local feature rather than as a configural feature in the analysis of facial beauty. We also discuss directions for future research that can clarify the role of the limbal ring in the visual perception of facial attractiveness.     

Association of the DAT1 genotype with inattentive behavior is mediated by reading ability in a general population sample

Attention deficit hyperactivity disorder (ADHD) and reading disability (RD) frequently co-occur in the child population and therefore raise the possibility of shared genetic etiology. We used a quantitative trait loci (QTL) approach to assess the involvement of the dopamine transporter (DAT1) gene polymorphism in mediating reading disability and poor attention in a general population sample of primary school children aged 6-11 years in the UK. The potential confounding effects of IQ and chronological age were also investigated. We found an independent association between the homozygous DAT1 10/10 repeat genotype and RD that was not accounted for by the level of ADHD symptoms. This finding suggests that the DAT1 gene polymorphism may influence a common neural mechanism underlying both reading acquisition and ADHD symptoms.     

Extending the metatheoretical framework of social/political influence to leadership: Political skill effects on situational appraisals,responses, and evaluations by others

Building off and extending the metatheoretical framework of political skill, we examined the cognitive and behavioral mechanisms through which the intrapsychic effects of political skill inform its interpersonal effects, and how these interpersonal effects ultimately are transmitted into desirable outcomes. Specifically, we argue that politically skilled leaders demonstrate better situational appraisals (i.e., understanding), and thus, more appropriate situational responses (e.g., consideration and initiating structure behaviors); the demonstration of appropriate situational responses is argued to positively affect subordinates’ evaluations of their leaders (i.e., instrumentality) and subordinates’ concomitant attitudes (e.g., job satisfaction) and behaviors (e.g., performance). Results provided mixed support for the hypothesized relationships. Specifically, leader understanding mediated the relationship between political skill and consideration but not the relationship between political skill and structuring behaviors. Moreover, consideration was positively related to subordinates’ group-level instrumentality perceptions, whereas initiating structure was not. Finally, subordinates’ individual (within-level) perceptions of leader instrumentality were positively related to job satisfaction and performance. The implications of these findings as they relate to theory and practice are discussed along with this investigation's strengths, limitations, and directions for future research.     

African–American Religious Affiliation in the Late 20th Century: Cohort Variations and Patterns of Switching, 1973–1998

This article investigates shifts in religious affiliation among African Americans over the last three decades and across cohorts. I examine data from the 1973–1998 General Social Surveys to analyze denominational growth and decline, and patterns of religious switching. I compare variations in religious loyalty/switching and patterns of mobility across eight salient religious groupings; cohort variations are tested across pre– and post–civil rights cohorts. I examine a range of log–linear and log–multiplicative models to summarize patterns of switching and to see whether patterns vary across cohorts. I find that the "black mainline" Methodist and Baptist denominations lose members from switching and have lower market share because of the ascendance of conservative sects. Further, nonaffiliation is growing, particularly in the post–civil rights cohort. I found no variations in patterns of mobility over time or across cohorts—only in the rates of switching that drive the levels of mobility.     

A Sociological Assessment of Centenarians from Central Illinois Cemeteries, 1825–1985

Centenarians, the fastest growing age group in the United States, recently have become the focus of medical and social research. However, historically, little is known of centenarians beyond anecdotal narrative. This research identifies 60 centenarians from 55,914 burials between 1825 and 1985 in a single Midwest county. These centenarians are compared to a sample of burials from the same county and time span, and to patterns of current centenarians. The prevalence of centenarians, historically, compares more favorably with current prevalence rates than anticipated, suggesting regional concentrations of the oldest old. Racial crossover was found, as anticipated, but historically, centenarians were not as disproportionately female as is the contemporary centenarian population. Seasonal death patterns of centenarians are similar to, but more exaggerated than, the seasonal patterns of younger elderly. Finally, findings suggest that centenarians came from larger families than noncentenarians, and that these families experienced greater longevity.     

Turning an advantage into a disadvantage: Ambiguity effects in lexical decision versus reading tasks

When performing a lexical decision task, participants can correctly categorize letter strings as words faster if they have multiple meanings (i.e., ambiguous words) than if they have one meaning (i.e., unambiguous words). In contrast, when reading connected text, participants tend to fixate longer on ambiguous words than on unambiguous words. Why are ambiguous words at an advantage in one word recognition task, and at a disadvantage in another? These disparate results can be reconciled if it is assumed that ambiguous words are relatively fast to reach a semantic-blend state sufficient for supporting lexical decisions, but then slow to escape the blend when the task requires a specific meaning be retrieved. We report several experiments that support this possibility.     

Neural correlates of person recognition

Rapidly identifying known individuals is an essential skill in human society. To elucidate the neural basis of this skill, we monitored brain activity while experimental participants demonstrated their ability to recognize people on the basis of viewing their faces. Each participant first memorized the faces of 20 individuals who were not known to the participants in advance. Each face was presented along with a voice simulating the individual speaking their name and a biographical fact. Following this learning procedure, the associated verbal information could be recalled accurately in response to each face. These learned faces were subsequently viewed together with new faces in a memory task. Subjects made a yes-no recognition decision in response to each face while also covertly retrieving the person-specific information associated with each learned face. Brain activity that accompanied this retrieval of person-specific information was contrasted to that when new faces were processed. Functional magnetic resonance imaging in 10 participants showed that several brain regions were activated during blocks of learned faces, including left hippocampus, left middle temporal gyrus, left insula, and bilateral cerebellum. Recordings of event-related brain potentials in 10 other participants tracked the time course of face processing and showed that learned faces engaged neural activity responsible for person recognition 300-600 msec after face onset. Collectively, these results suggest that the visual input of a recently learned face can rapidly trigger retrieval of associated person-specific information through reactivation of distributed cortical networks linked via hippocampal connections.     

MFT Students’ Recount Experiences of Attending Phone and Online Overeaters Anonymous Meetings

The purpose of this study was to explore Marriage and Family Therapy students’ experiences attending Overeaters Anonymous (OA). Utilizing a qualitative survey administered in an addictions course at an institution located in a rural area of the United States, 18 marriage and family therapy (MFT) graduate students reflected on their participation in both online and telephone meetings. In this study, MFT students provided their perspectives regarding the feasible utilization of Overeaters Anonymous in clinical treatment, with an emphasis on the consideration of social support for clients who may reside in rural areas. Three major themes emerged which included (1) enlightenment through exposure; (2) OA as a viable adjunct to therapy; and (3) convenience and comfort. The study addressed recommendations for MFT education, clinical implications, and future research.