The fragile X mental retardation protein, FMRP, recognizes G-quartets

Fragile X mental retardation is a disease caused by the loss of function of a single RNA-binding protein, FMRP. Identifying the RNA targets recognized by FMRP is likely to reveal much about its functions in controlling some aspects of memory and behavior. Recent evidence suggests that one of the predominant RNA motifs recognized by the FMRP protein is an intramolecular G-quartet and that the RGG box of FMRP mediates this interaction. Searching databases of mRNA sequence information, as well as compiled sequences of predicted FMRP targets based on biochemical identification, has revealed that many of these predicted FMRP targets contain intramolecular G-quartets. Interestingly, many of the G-quartet containing RNA targets encode proteins involved in neuronal development and synaptic function. Defects in the metabolism of this set of RNAs, presumably in the translation of their protein products, is likely to underlie the behavioral and cognitive changes seen in the disease.     

Social Representations of Human Rights Amongst Czech University Students

The Universal Declaration of Human Rights is a general legislative framework for democratic societies. Studying the social representations of these basic human rights helps to explain how people understand and assess the basic rights and how these rights relate to everyday life. Over 400 Czech university students rated the 30 articles of the Declaration of Human Rights on various scales (degree of understanding, personal relevance, consequences for individual responsibility, for government, political parties, etc.). A semantic space was identified in which concepts (i.e. the Articles of the Declaration) could be located. A typology (clusters) of articles was then established within that semantic space. A factor analysis of the scales resulted in a two-dimensional solution (‘positive attitude’ and ‘personal influence’). Five clusters of assessed articles were identified within this semantic space. (© 1997 by John Wiley & Sons, Ltd.)     

Systems change as an outcome and a process in the work of community collaboratives for health

The widespread development of comprehensive community initiatives that aim to improve community health is driven by the need to change the systems charged with delivering the services and creating the policies related to a variety of health outcomes. Georgia's Family Connection initiative is the nation's largest statewide network of community collaboratives for health, with collaboratives operating in 159 counties. Data on community context, collaborative processes, engagement in systems change, and changes in programs and activities implemented, gathered consistently at the collaborative level over 3 years, will be used to answer the following questions. How do community contexts and the structure and processes of collaboratives affect implementation of systems change? How do systems changes affect intermediate outcomes such as the type of programs offered in a community? Longitudinal change in systems change and program implementation is described and significant predictors of between‐collaborative variation in longitudinal change for each outcome are identified.     

Culture in the context of intercultural negotiation.

This study explores culture's effect on behaviors and outcomes in intercultural negotiation and examines how those effects are moderated by role. Eighty U.S. and international students took part in a previously developed negotiation task (Pruitt, 1981) and completed Hui and Triandis's (1986) individualism‐collectivism (INDCOL) scale. Negotiation interactions were coded for information sharing, offers, and distributive tactics. Findings show that a negotiation dyad's collectivism is positively associated with higher joint profit. The effects of culture on both communication behaviors and joint outcomes, however, differ by role of the negotiator. In particular, seller collectivism has larger and more consistent effects on communication behavior and joint profit than buyer collectivism. Results support a ‘culture in context’ perspective of negotiation that takes into account negotiator qualities, contextual and structural features of the negotiation, and mediating processes in addition to cultural values.     

ON THE PRAGMATICS OF SOCIAL THEORY: THE CASE OF ELIAS'S “ON THE PROCESS OF CIVILIZATION”

This paper proposes a new approach to the study of sociological classics. This approach is pragmatic in character. It draws upon the social pragmatism of G. H. Mead and the sociology of texts of D. F. McKenzie. Our object of study is Norbert Elias's On the Process of Civilization. The pragmatic genealogy of this book reveals the importance of taking materiality seriously. By documenting the successive entanglements between human agency and nonhuman factors, we discuss the origins of the book in the 1930s, how it was forgotten for 30 years, and how in the mid‐1970s it became a sociological classic. We explain canonization as a matter of fusion between book's material form and its content, in the context of the paperback revolution of the 1960s, the events of May 1968, and the demise of Parsons’ structural functionalism, and how this provided Elias with an opportunity to advance his model of sociology.     

患者知情同意权实现的伦理思考与法律保护

随着医学科学的发展,患者的知情同意已是医学实践的一个基本伦理观念和原则,但是,它的实现不仅需要道德规范的约束,而且还需要法律的保护.     

Multilevel Measurement of Dimensions of Collaborative Functioning in a Network of Collaboratives that Promote Child and Family Well-Being

Evaluating collaboration between community partners presents a series of methodological challenges (Roussos and Fawcett in Annu Rev Public Health 21:369-402, 2000; Yin and Kaftarian 1997), one of which is selection of the appropriate level of analysis. When data are collected from multiple members of multiple settings, multilevel analysis techniques should be used. Multilevel confirmatory factor analysis (MCFA) is an analytic approach that incorporates the advantages of latent variable measurement modeling and multilevel modeling for nested data. This study utilizes MCFA on data obtained from an evaluation survey of collaborative functioning provided to members of 157 community collaboratives in Georgia. This study presents a well-fitting measurement model that includes five dimensions of collaborative functioning, and a structural component with individual- and collaborative-level covariates. Findings suggest that members' role and meeting attendance significantly predicted their assessment of collaboration at the individual level, and that tenure of collaborative leaders predicted the overall functioning of the collaborative at the collaborative level. Dimensionality of collaborative functioning and implications of potentially substantial measurement biases associated with selection of respondents are addressed.     

INVESTIGATING THE UTILITY OF THE FILM WAR ZONE IN THE PREVENTION OF STREET HARASSMENT

Street harassment, the act of sexual harassment by strangers in public, is a common experience shared by many women. This paper reports the first experimental evaluation of the impact of a popular documentary-style film,  War Zone , on men's attitudes toward street harassment and empathy for women who experience it. The sample was an ethnically diverse group of undergraduate men attending an urban university ( N  = 98). Given the film's primary focus on women's perspectives and the relation of street harassment to rape, we predicted the film would decrease acceptance of street harassment and increase empathy toward women who experience street harassment. We did not find support for these main effects. Hostility toward women, however, was negatively related to cognitive empathy and feelings of distress following the film, and hostility toward women moderated the effect of film condition on distress. Peer acceptance predicted greater self-acceptance of street harassment. Implications for future street harassment research and prevention strategies are discussed.     

Organizational Cultural Competence in Mental Health Service Delivery: A Multilevel Analysis

Statistical associations between individual and organizational dimensions of cultural competence were examined. Participants were 350 employees of 12 public mental health agencies in Atlanta. Results from hierarchical linear modeling indicated that agencies with culturally competent mission statements and training had significantly higher member perceptions of cultural competence within the organization. Las asociaciones estadísticas entre individuo y dimensiones de la organización de la competencia cultural se examinaron. Los participantes eran 350 empleados de 12 agencias mentales públicas de la salud en Atlanta. Los resultados del modelo linear jerárquico indicó que las agencias con declaraciones de objetivos culturalmente competentes y entrenamiento tenia las percepciones apreciablemente más altas del miembro de la competencia cultural dentro de la organización.