Where am I? Distal cues use requires sensitivity to start location change in the rat

Place learning is impaired when a single plus maze is moved between adjacent locations 33-120 cm apart. This maze translation creates distinct start locations but maintains a single goal location with respect to distal cues. Hippocampal cell recording data suggest the majority of place fields are tied to apparatus boundaries, not to distal cues, when an apparatus is moved these distances to the left or right. Thus, rats may fail to appreciate the existence of multiple start locations with respect to distal cues when the maze is moved in this way and their start location on the surface is constant. Performance on the single plus maze problem was improved when texture cues were correlated with different start locations. Place learning was supported when multiple start locations were provided on a single large surface (double plus maze), even though rats did not explore the entire surface. Place learning was also supported when random extensions were added to a double plus maze such that start locations, relative to surface boundaries, were not informative as to goal location. This outcome suggests sensitivity to multiple start locations is required for distal cue use in translational place problems.     

Does an estimate of environmental size precede size scaling on a form-comparison task?

In a number of studies reaction time has been found to increase with increases in size ratio on a same -different form-comparison task. Bennett and Warren (2002, Perception & Psychophysics 64 462-477) teased apart environmental and retinal size ratios by showing the forms along a (simulated) texture hallway, viewed monocularly, on a simultaneous form-comparison task; roughly equal effects of environmental and retinal size ratios were found. The current study enhanced scene-size information by showing the forms in simulated stereo and by adding texture to the forms themselves; special care was also taken to perceptually isolate the stimuli. In two experiments, with different kinds of forms, strong effects of environmental size ratio were found; no effect of retinal size ratio (same trials) was observed in either experiment. The results support the hypothesis that the (same-trial) form-size codings reflect 'all told' estimates of environmental size, and place constraints on modeling the functional architecture of the visual system.     

Negativity and lies in analytic group therapy: an inquiry into Bion's ideas of K and -K

In this paper a kind of therapeutic failure in psychoanalytic group work, one that is common but frequently overlooked, is described. Essentially this failure is the result of patients who mislead the therapist by lying and by a negative process of thought that works against analytic aims of acquiring understanding and emotional truth. These processes and their effects, as they are manifested by an individual patient in a group and by the therapist, are described. Bion's later theory of K and -K offers a framework for the discussion of the group events.     

An Empowerment Evaluation Model for Sexual Assault Programs: Empirical Evidence of Effectiveness

Using an empowerment evaluation approach, the Sexual Assault and Rape Prevention (SARP) Evaluation Project brought together university researchers, public health evaluators, state funders, and program staff to provide evaluation training and consultation to all state-funded rape prevention and victim services programs in Michigan. In this paper, the specific activities of the SARP project are described, and process and outcome data are presented that address the effectiveness of this empowerment evaluation approach. Based on subjective reports from program staff and objective data obtained from state funders, results suggest that this evaluation model was successful in helping 90% of the prevention programs and 75% of the victim services programs successfully develop and launch program evaluations. One-year follow-up data indicate that 90% of the programs had sustained their evaluation efforts after the formal work of the SARP project had ended.     

Bouts of responding: the relation between bout rate and the rate of variable-interval reinforcement

By nose poking a lighted key, rats obtained food pellets on either a variable-interval schedule of reinforcement or a schedule that required an average of four additional responses after the end of tile variable-interval component (a tandem variable-interval variable-ratio 4 schedule). With both schedule types, the mean variable interval was varied between blocks of sessions from 16 min to 0.25 min. Total rate of key poking increased similarly as a function of the reinforcer rate for the two schedule types, but response rate was higher with than without the four-response requirement. Analysis of log survivor plots of interresponse times showed that key poking occurred in bouts. The rate of initiating bouts increased as a function of reinforcer rate but was either unaffected or was decreased by adding the four-response requirement. Within-bout response rate was insensitive to reinforcer rate and only inconsistently affected by the four-response requirement. For both kinds of schedule, the ratio of bout time to between-bout pause time was approximately a power function of reinforcer rate, with exponents above and below 1.0.     

Short- and Long-Term Impact of Receiving Genetic Mutation Results in Women at Increased Risk for Hereditary Breast Cancer

Forty-seven unaffected women from high-risk breast cancer families who had received results for hereditary breast/ovarian predisposition genes between 1 month and 5 years ago were interviewed regarding their experiences. Women responded to open-ended questions. The initial emotional turmoil reported by most was generally short lived. However, the impact of genetic testing went beyond the individual to the extended family and social context, particularly in the short-term. A common theme was the difficulty associated with divulging a result to family members, who were also adjusting to their own result. The majority of carriers reported advantages that were both physical (options for surveillance programs and prophylactic surgery) and emotional (reduced uncertainty, increased awareness of options and knowledge about risk, preparation time). Most carriers reported no change in lifestyle although some reported discovering their mutation status as a positive life-changing experience. Implications for genetic counseling and further research are discussed.     

Reactive vs. proactive antisocial behavior: differential correlates of child ADHD symptoms?

This study examines the relation between proactive and reactive antisocial behavior with Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms. Caregivers of children aged 8 to 15 (n = 84) being evaluated at a child psychiatry outpatient clinic served as participants. Given the conceptual similarity between reactive antisocial behavior (ASB) and particular ADHD symptoms, we hypothesized that ADHD symptoms would be more closely related to reactive than to proactive ASB. Based on peer deviancy training models of ASB, we also hypothesized that the relation between ADHD symptoms and proactive ASB would increase from middle childhood to adolescence. Both hypotheses were supported. These findings suggest that reactive ASB is relatively specific to ADHD symptoms, and that intervening before early adolescence may be critical to prevent the onset of comorbid proactive ASB.     

Optimizing treatment in social phobia: a review of treatment resistance

Over the last 25 years, there has been a rapid expansion of our knowledge base of social phobia (SP). Although there are a number of well-validated treatment modalities, including pharmacotherapy and cognitive-behavioral therapy, significant gaps remain in our ability to achieve full remission in most patients. Despite advances in the neurobiology of SP, the etiology has yet to be determined. Investigations examining potential predictors of response have provided little guidance in selecting an appropriate treatment modality. These gaps in our knowledge have pushed us to examine issues related to treatment resistance. This paper presents a review of the current literature and issues related to treatment-resistant SP, including a discussion of the functional impairment associated with SP, definitions of treatment response and remission, as well as outcome measures that have been used in clinical investigations of SP. In addition, criteria for a standard treatment trial, predictors of treatment response, a review of treatment resistance studies, and potential directions for future research are examined. The most promising strategies to attain remission, will likely involve augmenting selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors with agents such as anticonvulsants, benzodiazepines, and antipsychotics as well as combining pharmacotherapy with cognitive-behavioral therapy. Our current treatment target of simply attaining a response needs to be refocused, so that an asymptomatic state and high end state functioning become the final goal of treatment.