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71.
Daphne Blunt Bugental Amelia Silbert-Geiger 《Journal of experimental child psychology》2010,106(1):30-40
Parental investment (involving time or money invested in 3-year-olds) and child health were assessed as an outcome of (a) children’s risk status (preterm vs. full-term birth) and (b) maternal resources (defined here in terms of their problem-solving skills in resolving caregiving challenges). Resources were varied systematically as a function of maternal participation in a traditional home visitation program versus a novel cognitively enhanced program that facilitated parenting skills more successfully. As predicted, mothers in the traditional home visitation condition invested preferentially in low-risk children, whereas mothers in the cognitively enhanced condition invested preferentially in high-risk children (who, in turn, showed maximal health benefits). Maternal investment of time in care provision mediated the relationship between predictor variables and children’s health. This pattern supports an evolutionary model of parental investment in which parents show discriminative solicitude based on the reproductive potential of the child and parents’ access to relevant resources. 相似文献
72.
Anushka V. Goonawardena Lianne Robinson Robert E. Hampson Gernot Riedel 《Learning & memory (Cold Spring Harbor, N.Y.)》2010,17(10):502-511
It is now well established that cannabinoid agonists such as Δ9–tetrahydrocannabinol (THC), anandamide, and WIN 55,212-2 (WIN-2) produce potent and specific deficits in working memory (WM)/short-term memory (STM) tasks in rodents. Although mediated through activation of CB1 receptors located in memory-related brain regions such as the hippocampus and prefrontal cortex, these may, in part, be due to a reduction in acetylcholine release (i.e., cholinergic hypofunction). To determine the interaction between cannabinoid and cholinergic systems, we exposed rats treated with WIN-2 or cholinergic drugs to a hippocampal-dependent delayed nonmatch to sample (DNMS) task to study STM, and recorded hippocampal single-unit activity in vivo. WIN-2 induced significant deficits in DNMS performance and reduced the average firing and bursting rates of hippocampal principal cells through a CB1 receptor-mediated mechanism. Rivastigmine, an acetylcholinesterase inhibitor, reversed these STM deficits and normalized hippocampal discharge rates. Effects were specific to 1 mg/kg WIN-2 as rivastigmine failed to reverse the behavioral and physiological deficits that were observed in the presence of MK-801, an NMDA receptor antagonist. This supports the notion that cannabinoid-modulated cholinergic activity is a mechanism underlying the performance deficits in DNMS. Whether deficits are due to reduced nicotinic or muscarinic receptor activation, or both, awaits further analysis.Administration of both synthetic and phytocannabinoids, including Δ9–tetrahydrocannabinol (Δ9–THC), WIN 55,212-2 (WIN-2), and CP 55,940, impair working memory (WM) and short-term memory (STM) through a CB1 receptor-mediated mechanism in rats (Lichtman et al. 1995; Lichtman and Martin 1996; Hampson and Deadwyler 1998, 1999, 2000; Braida and Sala 2000; Egashira et al. 2002). This suggestive evidence for endocannabinoid involvement in memory formation was confirmed by Terranova and coworkers (1996), who demonstrated that the CB1 receptor antagonist rimonabant facilitated short-term olfactory memory, and this was partially reversed by the muscarinic receptor antagonist scopolamine. This suggests an interaction between cannabinoid and cholinergic systems such that endocannabinoid tone suppresses cholinergic transmission. Consequently, rats pretreated with eptastigmine, a second-generation cholinesterase inhibitor remained unaffected by the full CB1 receptor agonist CP 55,940 when tested in an eight arm radial maze (Braida and Sala 2000). And more recent evidence from Mishima and coworkers (2002) suggests that a block of cholinesterase with physostigmine and tetrahydroaminoacridine protects against WM impairments induced by Δ9–THC. These findings further support a potential role of the cholinergic system in cannabinoid-induced memory impairments.The exact mechanisms for this interaction still remain elusive, although cholinergic projection neurons from medial septum to hippocampus are likely to play an important role (Harkany et al. 2003, 2005; Fitz et al. 2008). However, the neuromodulatory action of pharmacologically active cannabinoids on septo-hippocampal cholinergic activity in vivo remains unexplored. Within the hippocampus, cannabinoids presynaptically inhibit the release of acetylcholine, possibly through the activation of CB1 receptors located on cholinergic nerve terminals given that these effects were blocked by rimonabant (Gifford and Ashby Jr. 1996; Gifford et al. 1997a, 2000; Kathmann et al. 2001a). Direct in vivo microdialysis studies in awake rats also showed cannabinoid-induced decreases in acetylcholine release in the hippocampus through a CB1 receptor-mediated mechanism (Gessa et al. 1997; Carta et al. 1998). High doses of rimonabant alone increase the amount of acetylcholine release in the hippocampus (Gessa et al. 1997, 1998) either by blocking the tonic inhibitory influence of endocannabinoids and/or through its inverse agonism at CB1 receptors. Such actions are in agreement with a 100% greater increase in electrically evoked hippocampal acetylcholine release in CB1−/− mice (Kathmann et al. 2001b).In contrast, low doses of Δ9–THC (0.01–0.15 mg/kg), WIN-2 (0.01–0.5 mg/kg), and HU-210 (0.001–0.004 mg/kg) have been shown to enhance acetylcholine release (Acquas et al. 2000, 2001), indicating that cannabinoid modulation of acetylcholine release in the hippocampus is “biphasic.” This has been further supported by the work carried out by Tzavara and coworkers (2003), who demonstrated that low (0.5 mg/kg, intraperitoneally [i.p.]) and high (5 mg/kg, i.p.) doses of WIN-2 induce transient stimulation and prolonged inhibition of hippocampal acetylcholine efflux, respectively. This demonstrates that the dose of cannabinoids plays a key role in determining how much acetylcholine is released in the hippocampus.Such an interaction is likely to play an important role during the performance of a delayed nonmatch to sample (DNMS) task but has not been explored. Hence, a comprehensive pharmacological assessment was carried out here to (1) reveal the existence of such an interaction in terms of DNMS performance and (2) assess a possible cannabinoid-acetylcholine cross-talk on burst characteristics of hippocampal principal cells in CA3 and CA1. 相似文献
73.
Adults appear to be more sensitive to configural information, including second-order relations (the spacing of features), in faces than in other objects. Superior processing of second-order relations in faces may arise from our experience of identifying faces at the individual level of categorisation (eg Bob versus John) but other objects at the basic level of categorisation (eg table versus chair; Gauthier and Tarr, 1997 Vision Research 37 1673- 1682). We simulated this learning difference with novel stimuli (comprised of blobs) by having two groups view the same stimuli but learn to identify the objects only at the basic level (based on the number of constituent blobs) or at both the basic level and individual level (based on the spacing, or second-order relations, of the blobs) of categorisation. Results from two experiments showed that, after training, observers in the individual-level training group were more sensitive to the second-order relations in novel exemplars of the learned category than observers in the basic-level training group. This is the first demonstration of specific improvement in sensitivity to second-order relations after training with non-face stimuli. The findings are consistent with the hypothesis that adults are more sensitive to second-order relations in faces than in other objects, at least in part, because they have more experience identifying faces at the individual level of categorisation. 相似文献
74.
Many letters of the alphabet are consistently mapped to specific colours by English-speaking adults, both in the general population and in individuals with grapheme-colour synaesthesia who perceive letters in colour. Such associations may be naturally biased by intrinsic sensory cortical organisation, or may be based in literacy (eg 'A' is for 'apple', apples are red; therefore A is red). To distinguish these two hypotheses, we tested pre-literate children in three experiments and compared their results to those of literate children (aged 7-9 years) and adults. The results indicate that some colour letter mappings (O white, X black) are naturally biased by the shape of the letter, whereas others (A red, G green) may be based in literacy. They suggest that sensory cortical organisation initially binds colour to some shapes, and that learning to read can induce additional associations, likely through the influence of higher-order networks as letters take on meaning. 相似文献
75.
Most previous studies investigating children’s ability to recognize facial expressions used only intense exemplars. Here we compared the sensitivity of 5-, 7-, and 10-year-olds with that of adults (n = 24 per age group) for less intense expressions of happiness, sadness, and fear. The developmental patterns differed across expressions. For happiness, by 5 years of age, children were as sensitive as adults even to low intensities. For sadness, by 5 years of age, children were as accurate as adults in judging that the face was expressive (i.e., not neutral), but even at 10 years of age, children were more likely to misjudge it as fearful. For fear, children’s thresholds were not adult-like until 10 years of age, and children often confused it with sadness at 5 years of age. For all expressions, including even happy expressions, 5- and 7-year-olds were less accurate than adults in judging which of two expressions was more intense. Together, the results indicate that there is slow development of accurate decoding of subtle facial expressions. 相似文献
76.
77.
78.
Sarah E Hampson Lewis R Goldberg Thomas M Vogt Joan P Dubanoski 《Health psychology》2007,26(1):121-125
OBJECTIVE: The purpose of this study was to test a life span health behavior model in which educational attainment and health behaviors (eating habits, smoking, and physical activity) were hypothesized as mechanisms to account for relations between teacher ratings of childhood personality traits and self-reported health status at midlife. DESIGN: The model was tested on 1,054 members of the Hawaii Personality and Health cohort, which is a population-based cohort participating in a longitudinal study of personality and health spanning 40 years from childhood to midlife. OUTCOME: Childhood Agreeableness, Conscientiousness, and Intellect-Imagination influenced adult health status indirectly through educational attainment, healthy eating habits, and smoking. Several direct effects of childhood traits on health behaviors and health status were also observed. CONCLUSION: The model extends past associations found between personality traits and health behaviors or health status by identifying a life-course pathway based on the health behavior model through which early childhood traits influence adult health status. The additional direct effects of personality traits indicate that health behavior mechanisms may not provide a complete account of relations between personality and health. 相似文献
79.
Using the National Survey of Families and Households (N = 13,017; 11.09% Black, 79.99% White), we compare the household labor time of Black and White women and men, and assess the
extent to which the time constraint, relative resource, and ideology explanations account for racial and gender differences
in housework time. We find that although time constraint, relative resource, and ideology explanations account for some of
the variation in housework time, they do not account for all of the gender and racial differences. We also find that paid
work and housework trade off differently for Black men than for White men and also for women and men. Finally, a variety of
relative resource, time constraint, and ideology factors are associated differently with women’s and men’s housework time.
We argue that our findings lend support to the production of gender approach to understanding the division of household labor
and that this approach can be used to help us understand racial differences in housework time as well.
We would like to thank the anonymous reviewers for their helpful comments. 相似文献
80.