End of Life Pediatric Research: What About the Ethics?

Clinical trials are required in order to develop new treatments and improve both patient life expectancy and quality of life. In this respect the last 10 years proved their efficiency. However clinical research shows one of the most difficult dilemmas from an ethical point of view. Patients included in clinical trials are submitted to known and unknown risks and hazards, but rarely benefit from the results. This is even more evident when clinical trials use children who are terminally ill. The core consideration becomes how far should we go with research when considering the child best interest.     

iSTART 2: Improvements for efficiency and effectiveness

iSTART (interactive strategy training for active reading and thinking) is a Web-based reading strategy trainer that develops students’ ability to self-explain difficult text as a means to improving reading comprehension. Its curriculum consists of modules presented interactively by pedagogical agents: an introduction to the basics of using reading strategies in the context of self-explanation, a demonstration of self-explanation, and a practice module in which the trainee generates self-explanations with feedback on the quality of reading strategies contained in the self-explanations. We discuss the objectives that guided the development of the second version of iSTART toward the goals of increased efficiency for the experimenters and effectiveness in the training. The more pedagogically challenging high school audience is accommodated by (1) a new introduction that increases interactivity, (2) a new demonstration with more and better focused scaffolding, and (3) a new practice module that provides improved feedback and includes a less intense but more extended regimen. Version 2 also benefits experimenters, who can set up and evaluate experiments with less time and effort, because pre- and posttesting has been fully computerized and the process of preparing a text for the practice module has been reduced from more than 1 person-week to about an hour’s time.     

Second-order conditioning in human predictive judgements when there is little time to think

Associative accounts uniquely predict that second-order conditioning might be observed in human predictive judgements. Such an effect was found for cue X in two experiments in which participants were required to predict the outcomes of a series of training trials that included P + and PX-, but only when training was paced by requiring participants to make a prediction within 3 s on each trial. In Experiment 1 training on P + ended before training was given on PX - . In Experiment 2 trials with P+, PX-, T + and other cues were intermixed. In the unpaced group inhibitory learning was revealed by a summation test, TX versus TM, where M was a control stimulus. These results suggest either that pacing interferes with learning successive associations more than with learning simultaneous associations or that lack of time to think interferes with inferential processes required for this type of inhibitory learning.     

Early impact of the BEST intervention for parents stressed by adolescent substance abuse

Youth involvement in substance abuse can be a source of considerable distress for their parents. Unilateral family interventions have been advocated as one means by which concerned family members can be supported to assist substance‐abusing family members. To date there has been little research examining the impact of unilateral family interventions on the directly participating family members. In this study the early impact of an 8‐week parent‐group programme known as Behavioural Exchange Systems Training (BEST) was evaluated using a quasi‐experimental, waiting list control design. The professionally led programme had been developed to support and assist parents in their efforts to cope with adolescent substance abuse. Subjects were 66 parents (48 families) accepted for entry into the programme between 1997 and 1998. Comparison was made between 46 parents offered immediate entry into the programme and 20 parents whose entry to the programme was delayed by an 8‐week waiting list. At the first assessment 87% of parents showed elevated mental health symptoms on the General Health Questionnaire. Evidence suggested exposure to the intervention had a positive impact on parents. Compared to parents on the waiting list, parents entered immediately into the intervention demonstrated greater reductions in mental health symptoms, increased parental satisfaction, and increased use of assertive parenting behaviours. Copyright © 2001 John Wiley & Sons, Ltd.     

Attributing “Third World Poverty” in Australia and Malawi: A Case of Donor Bias?1

Causal attributions for poverty in the developing world were examined from the perspectives of “actors” living in a “developing country” (Malawi) and “observers” living in a “developed country” (Australia). Ninety‐eight Malawian and 100 Australian weekend shoppers responded to the Causes of Third World Poverty Questionnaire (CTWPQ) and the Just World Scale (JWS), with Australian participants also providing information about their frequency of donating to foreign‐aid charities. Consistent with the actor–observer bias, Australians were more likely than were Malawians to attribute poverty to dispositional characteristics of the poor, rather than to situational factors. Among the Australians, situational attributions were in turn associated with frequency of donation behavior. The finding of a donor bias in this sample has important implications for the social marketing of foreign aid to Western donor publics.     

Do Additional Features Help or Hurt Category Learning? The Curse of Dimensionality in Human Learners

The curse of dimensionality, which has been widely studied in statistics and machine learning, occurs when additional features cause the size of the feature space to grow so quickly that learning classification rules becomes increasingly difficult. How do people overcome the curse of dimensionality when acquiring real‐world categories that have many different features? Here we investigate the possibility that the structure of categories can help. We show that when categories follow a family resemblance structure, people are unaffected by the presence of additional features in learning. However, when categories are based on a single feature, they fall prey to the curse, and having additional irrelevant features hurts performance. We compare and contrast these results to three different computational models to show that a model with limited computational capacity best captures human performance across almost all of the conditions in both experiments.     

Prompt comprehension in UNIX command production

We hypothesize that a cognitive analysis based on the construction-integration theory of comprehension (Kintsch, 1988) can predict what is difficult about generating complex composite commands in the UNIX operating system. We provide empirical support for assumptions of the Doane, Kintsch, and Polson (1989, 1990) construction-integration model for generating complex commands in UNIX. We asked users whose UNIX experience varied to produce complex UNIX commands, and then provided help prompts whenever the commands that they produced were erroneous. The help prompts were designed to assist subjects with respect to both the knowledge and the memory processes that our UNIX modeling efforts have suggested are lacking in less expert users. It appears that experts respond to different prompts than do novices. Expert performance is helped by the presentation of abstract information, whereas novice and intermediate performance is modified by presentation of concrete information. Second, while presentation of specific prompts helps less expert subjects, they do not provide sufficient information to obtain correct performance. Our analyses suggest that information about the ordering of commands is required to help the less expert with both knowledge and memory load problems in a manner consistent with skill acquisition theories.     

Aging increases the energetic demands of episodic memory: a cardiovascular analysis

We hypothesized that older volunteers allocate more attentional resources to memory maintenance than do younger volunteers. Allocation of a resource supporting memory maintenance was inferred from performance and cardiovascular measures. Eighteen 18- to 26-year-old men and eighteen 60- to 79-year-old men performed a serial memory task both as a single task and as a dual task that added simple reaction time stimuli. Items presented early or later in the serial list created relatively low or high memory load. The results suggested that older men allocated greater attention to memory maintenance, particularly during high-memory-load items. They showed a slowing of dual-task reaction time and increased heart rate during high- vs. low-memory-load items. Cardiac and vascular reactions further suggested that memory maintenance is supported by phasic autonomic adjustments and that with age, more of this support is required for adequate maintenance of episodic memory.