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191.
Effect of speech task on intelligibility in dysarthria: a case study of Parkinson's disease 总被引:2,自引:0,他引:2
This study assessed intelligibility in a dysarthric patient with Parkinson's disease (PD) across five speech production tasks: spontaneous speech, repetition, reading, repeated singing, and spontaneous singing, using the same phrases for all but spontaneous singing. The results show that this speaker was significantly less intelligible when speaking spontaneously than in the other tasks. Acoustic analysis suggested that relative intensity and word duration were not independently linked to intelligibility, but dysfluencies (from perceptual analysis) and articulatory/resonance patterns (from acoustic records) were related to intelligibility in predictable ways. These data indicate that speech production task may be an important variable to consider during the evaluation of dysarthria. As speech production efficiency was found to vary with task in a patient with Parkinson's disease, these results can be related to recent models of basal ganglia function in motor performance. 相似文献
192.
Synesthetic color experiences influence memory 总被引:2,自引:0,他引:2
We describe the extraordinary memory of C, a 21–year–old student who experiences synesthetic colors (i.e., photisms) when she sees, hears, or thinks of digits. Using three matrices of 50 digits, we tested C and 7 nonsynesthetes to evaluate whether C's synesthetic photisms influence her memory for digits. One matrix consisted of black digits, whereas the other two matrices consisted of digits that were either incongruent or congruent with the colors of C's photisms. C's recall of the incongruently colored digits was considerably poorer than her recall of either the black or the congruently colored digits. The 7 nonsynesthetes did not show such differences in their recall of the matrices. In addition, when immediate recall of the black digits was compared with delayed recall of those digits (48 hr), C showed no decrease in performance, whereas each of the nonsynesthetes showed a significant decrease. These findings both demonstrate C's extraordinary memory and show that her synesthetic photisms can influence her memory for digits. 相似文献
193.
How well do brief screening measures correspond with a full-scale assessment of psychopathy among juvenile offenders? This study compared 3 independent screening measures (the Antisocial Process Screening Device [APSD] Self-Report [A. A. Caputo, P. J. Frick, & S. L. Brodsky, 1999], the APSD Staff Rating [P. J. Frick & R. D. Hare, 2001], and the Psychopathy Content Scale [D. C. Murrie & D. G. Cornell, 2000] on the Millon Adolescent Clinical Inventory [T. Millon, 1993]) with the Psychopathy Checklist: Youth Version (PCL:YV; A. E. Forth, D. S. Kosson, & R. D. Hare, in press) in a sample of 117 incarcerated male juveniles. Modest correlations (.30-.49) were found between PCL:YV scores and those of the 3 screening measures, and there was moderate accuracy (67%-82%) in identifying youth who scored relatively high (> or = 25) on the PCL:YV. Although these results support the construct of adolescent psychopathy, they indicate substantial limitations in the use of psychopathy screening measures with juvenile offenders. 相似文献
194.
The ALCOVE model of category learning, despite its considerable success in accounting for human performance across a wide
range of empirical tasks, is limited by its reliance on spatial stimulus representations. Some stimulus domains are better
suited to featural representation, characterizing stimuli in terms of the presence or absence of discrete features, rather
than as points in a multidimensional space. We report on empirical data measuring human categorization performance across
a featural stimulus domain and show that ALCOVE is unable to capture fundamental qualitative aspects of this performance.
In response, a featural version of the ALCOVE model is developed, replacing the spatial stimulus representations that are
usually generated by multidimensional scaling with featural representations generated by additive clustering. We demonstrate
that this featural version of ALCOVE is able to capture human performance where the spatial model failed, explaining the difference
in terms of the contrasting representational assumptions made by the two approaches. Finally, we discuss ways in which the
ALCOVE categorization model might be extended further to use “hybrid” representational structures combining spatial and featural
components. 相似文献
195.
Kaufer DI 《CNS spectrums》2002,7(10):742-750
Historically, drugs that increase central cholinergic transmission have primarily been investigated for relieving cognitive symptoms in mild-to-moderate Alzheimer's disease. These efforts have led to the somewhat unexpected findings that cholinergic therapy has a beneficial effect on selected neuropsychiatric symptoms in AD across disease stages. In Parkinson's disease with dementia and dementia with Lewy bodies, cholinergic deficits are more severe than in AD, and there is emerging evidence that cholinesterase inhibitors are efficacious in treating core symptoms of attentional disturbance and psychosis. Recent data also suggest a rational basis for cholinergic therapy in vascular dementia. The cognitive and neuropsychiatric effects of cholinergic therapy observed in AD and other dementias form the crux of an integrative model of cholinergic therapeutic efficacy that encompasses the diverse central nervous system actions of acetylcholine and its complementary interactions with central monoamine transmitters. This heuristic framework highlights the broader therapeutic potential of cholinergic therapy for symptom-based indications in other neuropsychiatric disorders. 相似文献
196.
Daniel Tr?hler 《Studies in Philosophy and Education》2000,19(1):219-221
Biography
Notes on Contributors 相似文献197.
Daniel Liechty 《Journal of religion and health》2000,39(3):247-260
This paper outlines some of the special stresses that must be shouldered by clinicians—physicians, nurses, chaplains, social workers, pastoral staff, and others—whose work focuses on dying and extremely vulnerable patients. The utility of a theory of generative death anxiety as a framework for interpreting the nature of these special stresses is suggested. Three common burnout reactions are examined. The paper concludes that positive acceptance of personal mortality may help clinicians avoid burnout and lead to better therapeutic practice. This framework for interpreting therapeutic practice demonstrates the integral role spirituality plays in work with this particular patient group. 相似文献
198.
Implicit motor sequence learning is represented in response locations 总被引:17,自引:0,他引:17
Previous work (Willingham, 1999) has indicated that implicit motor sequence learning is not primarily perceptual; that is, what is learned is not a sequence of stimuli. Still other work has indicated that implicit motor sequence learning is not specific to particular muscle groups or effectors. In the present work, we tested whether implicit motor sequence learning would be represented as a sequence of response locations. In Experiment 1, learning showed very poor transfer when the response locations were changed, even though the stimulus positions were unchanged. In Experiment 2, participants switched their hand positions at transfer, so that one group of participants pushed the same sequence of keys but used a different sequence of finger movements to do so, whereas another group pushed a different sequence of keys but used the same sequence of finger movements used at training. Knowledge of the sequence was shown at transfer only if the sequence of response locations was maintained, not the sequence of finger movements. 相似文献
199.
Andersen D;Danish Committee on Scientific Dishonesty 《Science and engineering ethics》2000,6(1):25-34
In 1992, The Danish Medical Research Council established a national committee on scientific dishonesty with the twofold task
of handling cases of scientific misconduct and taking preventive initiatives. Scientific dishonesty was proven in only five
cases, but in another nine cases lesser degrees of deviations from good scientific practice were found. The experiences from
a total of 24 treated cases indicated that three key areas were at the basis of most of the accusations and the deviations
from good practice: uncertainty about 1) authorship, about 2) rights and duties to use scientific data and about 3) agreements
at the initiation of joint studies. As a consequence guidelines on good practice have been issued on these key subjects.
An earlier version of this paper was presented at a symposium, Scientific Misconduct. An International Perspective, organised by The Medical University of Warsaw, 16 November, 1998. 相似文献
200.