Temperament Variation in Sensitivity to Parenting: Predicting Changes in Depression and Anxiety

Temperament was examined as a moderator of maternal parenting behaviors, including warmth, negativity, autonomy granting, and guidance. Observations of parenting and questionnaire measures of temperament and adjustment were obtained from a community sample (N = 214; ages 8–12). Trajectories of depression and anxiety were assessed across 3 years. The pattern of parenting as a predictor of internalizing symptoms depended on temperament. Maternal negativity predicted increases in depression for children low in fear. Effortful control moderated sensitivity to maternal negativity, autonomy granting, and guidance. Children low in effortful control reported more symptoms in the presence of negative or poor-fitting parenting. The results support differential responding, but also suggest that temperament may render children vulnerable for the development of problems regardless of parenting.     

Emotional Dynamics in the Development of Early Adolescent Psychopathology: A One-Year Longitudinal Study

This study examined the role of the level and variability of happiness, anger, anxiety, and sadness in the development of adolescent-reported anxiety disorder symptoms, depressive symptoms, and aggressive behavior in 452 adolescents (250 male) followed from age 13 to 14. Level and between-day variability of emotions were assessed through adolescent report at 3-month intervals across a 1 year period. Level and variability of the four emotions contributed to changes in anxiety disorder and depressive symptoms more consistently than to changes in aggressive behavior. All four emotions were predictive of changes in internalizing problems, while anger played the most prominent role in the development of aggressive behavior. Variability of emotions contributed to changes in anxiety disorder symptoms, while heightened levels of negative emotions and diminished happiness contributed to changes in depression. Results suggested somewhat stronger effects of negative affect on aggressive behavior for females than for males. Results underscore the role of emotion dysregulation in the development of psychopathology.     

Dimensions and Latent Classes of Episodic Mania-Like Symptoms in Youth: An Empirical Enquiry

The dramatic increase in diagnostic rates of bipolar disorder in children and adolescents in the USA has led to an intense interest in the phenomenology of the disorder. Here we present data from a newly-developed instrument to assess episodic mania-like symptoms in youth in a large population-based sample (N = 5326) using parent- and self-report. We found that a substantial proportion of children screened positive for having episodes of “going high” and were at an increased risk for morbidity and impairment. Using factor analysis, we identified that episodic mania-like symptoms comprised two dimensions: An under-controlled dimension that was associated with significant impairment, and a low-risk exuberant dimension. Using latent class analysis, we identified a small group of children scoring high on a range of manic symptoms and suffering from severe psychosocial impairment and morbidity. Our results carry implications for the nosology and psychosocial impairment associated with episodic mood changes in young people.     

Association of <Emphasis Type="Italic">ADAM10</Emphasis> and <Emphasis Type="Italic">CAMK2A</Emphasis> Polymorphisms with Conduct Disorder: Evidence from Family-Based Studies

Twin and family studies have shown that genetic factors play a role in the development of conduct disorder (CD). The purpose of this study was to identify genetic variants associated with CD using a family-based association study. We used 4,720 single nucleotide polymorphisms (SNPs) from the Illumina Panel and 11,120 SNPs from the Affymetrix 10K GeneChips genotyped in 155 Caucasian nuclear families from Genetic Analysis Workshop (GAW) 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). 20 SNPs had suggestive associations with CD (p < 10⁻³), nine of which were located in known genes, including ADAM10 (rs383902, p = 0.00036) and CAMK2A (rs2053053, p = 0.00098). Our results were verified using the International Multi-Center ADHD Genetics Project (IMAGE) dataset. In conclusion, we identified several loci associated with CD. Especially, the two genes (ADAM10 and CAMK2A) have been reported to be associated with Alzheimer’s disease, bipolar disorder and depression. These findings may serve as a resource for replication in other populations.     

Modifying Threat-related Interpretive Bias in Adolescents

Socially anxious feelings sharply increase during adolescence and such feelings have been associated with interpretive biases. Studies in adults have shown that interpretive biases can be modified using Cognitive Bias Modification procedures (CBM-I) and subsequent effects on anxiety have been observed. The current study was designed to examine whether the CBM-I procedure has similar effects in adolescents. Unselected adolescents were randomly allocated to either a positive interpretation training (n = 88) or a placebo-control condition (n = 82). Results revealed that the training was successful in modifying interpretations and effects generalized to a new task. The interpretive bias effects were most pronounced in individuals with a threat-related interpretive bias at pre-test. No effects on state anxiety were observed. The current findings are promising with regard to applying bias modification procedures to adolescents, while further research is warranted regarding emotional effects.     

Stability and Invariance of Psychopathic Traits from Late Adolescence to Young Adulthood

The current study examined the longitudinal stability and invariance of psychopathic traits in a large community sample of male twins from ages 17 to 23. Participants were assessed across 6 years to gauge the stability and measurement invariance of the Minnesota Temperament Inventory (MTI), a Cleckley-based measure of psychopathic personality traits, and how family functioning and externalizing behavior were linked to these traits. A latent variable approach was used to model the structure of the MTI and provide a statistical test of measurement invariance across time. The results revealed support for invariance and moderate to strong stability of the MTI factors, which showed significant associations with the external correlates in late adolescence but not early adulthood.     

Assessing interpersonal functioning: Views from within and without

In order to better integrate research on personality pathology, interpersonal problems, and social skills, we applied the traditional methods of these three research strands (questionnaires, interviews, and interpersonal role-plays) to the same sample. Participants who attributed higher levels of interpersonal problems to themselves in general were also more critical of their own role-play performances, but these impressions were not mirrored by observer-ratings. Self-observer agreement in judging overall role-play performance was essentially zero. Interviewer-ratings of personality pathology had incremental validity over self-ratings in predicting observer-rated role-play performance. Self-reports of interpersonal functioning leave relevant behavioral variance untapped and thus should be complemented by other sources of information.     

The Dopamine Receptor D4 Gene (<Emphasis Type="Italic">DRD4</Emphasis>) Moderates Family Environmental Effects on ADHD

Attention-Deficit/Hyperactivity Disorder (ADHD) is a prime candidate for exploration of gene-by-environment interaction (i.e., G x E), particularly in relation to dopamine system genes, due to strong evidence that dopamine systems are dysregulated in the disorder. Using a G x E design, we examined whether the DRD4 promoter 120-bp tandem repeat polymorphism, previously associated with ADHD, moderated the effects of inconsistent parenting and marital conflict on ADHD or Oppositional-Defiant Disorder (ODD). Participants were 548 children with ADHD and non-ADHD comparison children and their parents. Homozygosity for the DRD4 promoter 120-bp tandem repeat insertion allele increased vulnerability for ADHD and ODD only in the presence of inconsistent parenting and appeared to increase susceptibility to the influence of increased child self-blame for marital conflict on ADHD inattention. DRD4 genotypes may interact with these proximal family environmental risk factors by increasing the individual’s responsivity to environmental contingencies.     

Transactional Associations Between Youths’ Responses to Peer Stress and Depression: The Moderating Roles of Sex and Stress Exposure

This study examined transactional associations between responses to peer stress and depression in youth. Specifically, it tested the hypotheses that (a) depression would predict fewer effortful responses and more involuntary, dysregulated responses to peer stress over time; and (b) fewer adaptive and more maladaptive responses would predict subsequent depression. Youth (M age = 12.41; SD = 1.19; 86 girls, 81 boys) and their maternal caregivers completed semi-structured interviews and questionnaires at three annual waves. Multi-group comparison path analyses were conducted to examine sex and stress-level differences in the proposed reciprocal-influence model. In girls and in youth exposed to high levels of peer stress, maladaptive stress responses predicted more depressive symptoms and adaptive stress responses predicted fewer depressive symptoms at each wave. These findings suggest the utility of preventive interventions for depression designed to enhance the quality of girls’ stress responses. In boys, depression predicted less adaptive and more maladaptive stress responses, but only at the second wave. These findings suggest that interventions designed to reduce boys’ depressive symptoms may help them develop more adaptive stress responses.