Cholinergic-dopaminergic interactions in cognitive performance

Both acetylcholinergic (ACh) and dopaminergic (DA) systems have been found to be crucial for the maintenance of accurate cognitive performance. In a series of studies examining those aspects of cognitive function revealed by the radial-arm maze, we have found that these two neurotransmitter systems interact in a complex fashion. Choice accuracy deficits in the radial-arm maze can be induced by blockade of either muscarinic- or nicotinic-ACh receptors. The choice accuracy deficit induced by blockade of muscarinic receptors with scopolamine can be reversed by the DA receptor blocker, haloperidol. The specific DA D1 blocker SCH 23390 also has this effect, whereas the specific D2 blocker raclopride does not, implying that it is D1 blockade that is critical for reversing the scopolamine effect. On the other hand, the choice accuracy deficit induced by nicotinic blockade with mecamylamine is potentiated by haloperidol. This effect is also seen with the D2 antagonist raclopride, but not with the D1 antagonist SCH 23390, implying that it is the D2 receptor which is important for the potentiation of the mecamylamine effect. The relevance of the D2 receptor for nicotinic actions on cognitive function is emphasized by the finding that the selective D2 agonist LY 171555 reverses the choice accuracy deficit caused by mecamylamine. Nicotinic and muscarinic blockade are synergistic in the deficit they produce. Antagonist doses subthreshold when given alone produce a pronounced impairment when given together. This latter deficit can be reversed by the D2 agonist LY 171555. These studies have outlined the complex nature of ACh-DA interactions with regard to cognitive function. Possible neural circuits for these interactions are discussed. The effectiveness of these selective DA treatments in reversing cognitive deficits due to ACh underactivation suggests a novel approach to treating cognitive dysfunction in syndromes such as Alzheimer's disease.     

Gender and health on the kibbutz

Gender differences in health status and illness behavior have been explained in terms of sex roles and gender-related personality traits. It may be hypothesized that in a community that is committed to gender-negating ideology, where men and women alike participate in public life, and housework and child care largely collectivized, gender health differences will disappear. The kibbutz movement is committed to the ideology of the emancipation of women: women fully participate in the labor force and decision making. Nonetheless, women on the kibbutz are responsible for the housework and are concentrated in feminine occupations. The kibbutz, then, allows us to test the relationship between gender ideology and participation in public life vs. gender roles and tasks, and health. The health behavior, health status, and illness behavior of 230 members of two kibbutzim, one religious and one secular, were studied. Men and women report similar health status and illness behavior; parental status is not related to health; and marital status is related to psychological distress only. Similar patterns were observed for the secular kibbutz and the religious one despite the more traditional division of labor in the latter.Medical student, supported by the National Fund for Medical Education, 35 Kneeland Street, Boston, MA 02111.     

Textbooks in Accredited Marriage and Family Therapy Programs

Although choices of required textbooks are important decisions in developing a course curriculum, faculty in marriage and family therapy training programs have few convenient resources to guide curriculum development. This article presents results of a survey of textbook selections of accredited marriage and family therapy programs within a regional affiliate of AAMFT. The five programs surveyed listed 108 different titles used in their curriculum. Only 12 texts were used by two programs, and only one text was used by more than two programs. This article presents the textbook selections by the six curricular areas of COAMFTE accreditation standards. The wide variety of textbooks used by programs leads us to conclude that no consensus exists about what textbooks best represent the core knowledge of marriage and family therapy. The body of knowledge taught in accredited marriage and family training programs reflects a distinct and autonomous body of knowledge.     

Anxious attachment and psychological distress in cardiac rehabilitation patients

This study investigated the relevance of anxious attachment to the differentiation of psychologically distressed and non-psychologically distressed cardiac patients. Attachment is a biologically based behavioral system in which proximity to a special other is sought or maintained to achieve a sense of safety and security. Anxious attachment, as the name denotes, fails to achieve the function of attachment in the sense of individuals having little or no confidence in the availability of their attachment figures. Empirically, three scales (feared loss of the attachment figure, proximity seeking and separation protest) capture the features of anxious attachment as elaborated by Bowlby. These scales were administered to 178 cardiac rehabilitation patients drawn from the cardiac rehabilitation program of the Calgary General Hospital. The results indicate that feared loss and proximity seeking differentiated psychologically distressed from non-psychologically distressed patients. The implications of this finding for the understanding of psychologically distressed cardiac patients are discussed.     

Content validity: A neglected strategy for developing managerial selection tests?

There is a lack of quick, valid, and cost effective methods for selection of low-and mid-level managerial personnel. Using content-valid methods to develop managerial selection instruments may reap substantial benefits for applicants as well as for the organizations using such tools. To this end, based upon extensive job analysis, a content-valid managerial selection test was developed. Criterion-based validity collected on the new instrument suggested that an instrument developed using content-valid procedures can also show acceptable levels of criterion validity.     

Meaning dominance norms for 120 homographs

Over the past two decades, homographs have been used in psychological experiments aimed at testing a variety of theoretical issues concerning memory and language. Often, such research requires prior knowledge of the dominance relations among various meanings of the homographs. Previously available homograph meaning norms are limited because they are now more than 10 years old, and they have typically reported only the two most dominant meanings even though many homographs have three or more common meanings. This paper presents normative data on 120 homographs from a relatively large, heterogeneous sample of subjects (N = 100). Meaning dominance was assessed by having subjects write the first definition that came to mind for each homograph. Definition responses were grouped by similarity, and the resulting meaning categories were verified against dictionary meaning classifications. The number of distinct meanings varied from two to six for the homographs investigated, and frequency of response is reported for all definition categories.     

Gender,psychological well-being and somatic cardiovascular risk factors

The purpose of this study is to determine associations between cardiovascular risk factors and subjective experience of psychological general well-being with special reference to gender-related differences. One hundred fifty white-collar workers in a car manufacturing plant in Sweden participated in a health care screening program. Subjective experience of psychological well-being was significantly correlated with cardiovascular risk factors among both men and women. There were, however, marked differences between the genders. For men, the following specific psychological variables were significantly correlated with cardiovascular risk factors: estimation of general health, anxiety, self-control and vitality. For women, more complex significant relationships between the two sets of variables were found. Moreover, the direction of the correlations differed between the genders. For example, men with cardiovascular risk factors, such as increased blood pressure, blood lipids and body mass index, reported significantly morepositive estimation of their general health. For women the relation was the opposite with a significantly positive correlation (p-0.004) between experience of good health and a low risk factor profile indicating the concordance between physiological and psychological parameters. Possible reasons for these sex differences are discussed.     

Perceptual and conceptual priming in a semantic reprocessing task

Two experiments are reported that addressed the relative involvement and nature of perceptual and conceptual priming in a semantically complex task. Both experiments investigated facilitation from repeated semantic comparison trials in which subjects decided whether two words had the same meaning (e.g.,moist damp). The first experiment compared the magnitude and persistence of perceptual and conceptual priming components. Perceptual priming effects were modest, and contrary to some previous evidence, they did not appear to be more persistent than nonperceptual priming effects. The second experiment investigated the memory processes involved when perceptual priming was eliminated through a modality change between prime and target trials. Evidence suggested that conceptual priming primarily involved memory for the meaning comparison processes rather than better access to existing memory for the stimulus words.