Antidepressant treatment of children: clinical relapse is unrelated to tricyclic plasma concentrations

Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.     

Frequency of neurologic-psychiatric findings in the late phase following minor and medium severe blunt craniocerebral injuries

The authors present a short review of the pertinent literature and report on their own neuropsychiatric findings following internal craniocerebral injuries, at the same time drawing attention to the necessity of psychological examination. Statistical comparisons with the international literature are complicated owing to the different classifications used for craniocerebral injuries.     

Cognitive styles: illusory phenomena

The relationship between cognitive style and illusion magnitude was examined using the assimilation and contrast Delboeuf distortions. As in previous research, field dependence correlated positively with assimilation; however, a significant negative correlation with contrast was also found, suggesting that, while field dependence may involve the illusory integration of the stimulus field, field independence may involve its equally illusory differentiation.     

Preference for decision structures in a social dilemma situation

Additional results from Rutte and Wilke's (1984) study are presented. In the context of a social dilemma situation two variables were manipulated: use and variance. Preference for various decision structures is the issue of the present paper. It appeared that a large majority structure and an unanimity structure were mast preferred. A small majority structure and a structure in which each decides for him/herself were intermediately preferred. Whereas a structure in which one person, a leader, decides for all was least preferred. Further analysis of these data suggested that only the latter two decision structures were influenced by the use and variance manipulations.     

Parents' teaching strategies with their children: The effects of parental and child status variables

The intent of the study was to examine the effects of parental (mother and father) and child (gender and communicative status) status variables on the teaching strategies used by parents in a paper-folding task. The linguistic and nonverbal strategies of 120 parent-child groupings were analyzed during paper-folding tasks. Parents' strategies were coded according cognitive demand and directiveness. Results indicated that strategies varied as a function of children's communicative status. Parents were less directive and more demanding of nonhandicapped children compared to handicapped children. Parents' strategies seemed to be determined by children's ability to sustain discourse. Results are discussed in terms of Vygotsky's notion of the zone of proximal development.This research was partially supported by a grant from the U.S. Office of Education, Office of Special Education (Grant No. G007902000) to I. Sigel and A. McGillicuddy-DeLisi at Educational Testing Service, Princeton, and from the Biomedical Research Support Grant Program, Division of Research Resources, N.I.H. (Grant No. BRSG 507RR07025-17) to the first two authors. We acknowledge the helpful comments of two anonymous reviewers.     

Suppression of corticosterone synthesis alters the behavior of hippocampally lesioned rats

The suppression of corticosterone synthesis with metyrapone (25 mg/kg) reduced the hyperactivity and altered the exploratory activity of hippocampally lesioned animals (HPC) in the open field to the level of cortical and sham controls (Experiment 1). In a second experiment, corticosterone (600 micrograms/kg) pretreatment 2 h, but not 1 h, before metyrapone partially restored the hyperactivity of HPC animals that had been decreased by the corticosteroid-suppressant drug. Alterations in exploratory behavior induced by metyrapone were also prevented by corticosterone pretreatment. The results suggest that the suppression of corticosterone in hippocampally lesioned animals produces a normalization of behavior that can be prevented by pretreatment with corticosterone.     

Physical self-efficacy and actualization

In his theorizing about self-actualization, Maslow speculated that physical ability and physical self-confidence were two aspects of cooperative dominance which were associated positively with actualization. These aspects of dominance bear close resemblance to the Perceived Physical Ability (PPA) and the Physical Self-Presentation Confidence (PSPC) dimensions of the Physical Self-Efficacy (PSE) Inventory. Accordingly, the PPA and PSPC scores of undergraduate men and women were correlated with their scores on the Personal Orientation Inventory (POI), a popular measure of actualization, to test Maslow's hypotheses. The results showed that, contrary to Maslow's claims, PPA is not a positive correlate of self-actualization. However, strong support was found for Maslow's contention that high-PSPC individuals are more likely to be actualizing than low-PSPC people. Also, Maslow's hypothesis that actualizers are high in global sensation seeking (SS) was tested. The data indicated that only male actualizers were high in various aspects of SS, but female actualizers were not. Multiple regression analyses revealed further that both SS and PSPC are primary contributors to POI for men, but only PSPC contributes significantly to POI for women. Discussion focused on the reasons why research findings showing that increases in physical fitness lead to increases in self-esteem cannot be used to support the view that physical fitness and actualization are linked positively.     

Reflex modification in the rat: the inhibitory effects of intensity and frequency changes in steady tones

In laboratory rats (as in humans) a low-intensity tone that precedes a high-intensity burst of noise by approximately 100 ms can reduce the amplitude of the startle reaction elicited by the burst of noise. A series of four experiments with rats investigated the relation between the inhibitory effects of tonal frequency change and the length of the silent period (gap) preceding it. The major findings were the following: (a) A gap in an otherwise continuous pure tone inhibited startle when the gap occurred approximately 100 ms prior to the noise burst. (b) Although an increase in gap duration increased the inhibition afforded by the gap, the maximum inhibition was yielded by gaps of 100 ms and greater; this maximum was equivalent to the inhibition yielded by the presentation of a postgap tone alone. (c) A shift in tonal frequency across a 10-ms gap yielded more inhibition than did the same gap with no frequency shift; again the shift yielded equivalent inhibition to the presentation of the postgap tone alone. (d) An increase in the frequency shift increased inhibition when the shift occurred across a 10-ms gap, but not when the shift occurred across a 100-ms gap.