小剂量吗啡对大鼠活动性的影响

腹腔注射不同剂量吗啡,观察各组大鼠在给药后不同时间的活动性（ｌｏｃｏｍｏｔｏｒａｃｔｉｖｉｔｙ,ＬＡ）,连续给药８天,每天给药后９５ｍｉｎ内,每间隔１５ｍｉｎ,记录大鼠５ｍｉｎ内在限定空间中所走格数。结果表明：随吗啡给药剂量或次数增加,ＬＡ呈升高趋势;使大鼠ＬＡ明显兴夯的适宜低剂量为４ｍｇ／ｋｇ／ｄａｙ,该剂量下每天药后１５－２０ｍｉｎＬＡ为峰值,而且此时段ＬＡ逐日升高,至第８日出现下降趋势,此毕     

An improved stochastic EM algorithm for large-scale full-information item factor analysis

In this paper, we explore the use of the stochastic EM algorithm (Celeux & Diebolt (1985) Computational Statistics Quarterly, 2, 73) for large-scale full-information item factor analysis. Innovations have been made on its implementation, including an adaptive-rejection-based Gibbs sampler for the stochastic E step, a proximal gradient descent algorithm for the optimization in the M step, and diagnostic procedures for determining the burn-in size and the stopping of the algorithm. These developments are based on the theoretical results of Nielsen (2000, Bernoulli, 6, 457), as well as advanced sampling and optimization techniques. The proposed algorithm is computationally efficient and virtually tuning-free, making it scalable to large-scale data with many latent traits (e.g. more than five latent traits) and easy to use for practitioners. Standard errors of parameter estimation are also obtained based on the missing-information identity (Louis, 1982, Journal of the Royal Statistical Society, Series B, 44, 226). The performance of the algorithm is evaluated through simulation studies and an application to the analysis of the IPIP-NEO personality inventory. Extensions of the proposed algorithm to other latent variable models are discussed.     

Therapist Interventions Associated with Productive Emotional Processing in the Context of Attachment-Based Family Therapy for Depressed and Suicidal Adolescents

Productive emotional processing is considered a key change mechanism in attachment-based family therapy (ABFT). This study examined the impact of attachment-based family therapy therapist interventions aimed to promote productive emotional processing of primary adaptive emotions in a sample of 30 depressed and suicidal adolescents who had participated in a larger randomized clinical trial. Results of sequential analyses revealed that relational reframes and therapists’ focus on primary adaptive emotions were associated with the subsequent initiation of adolescents’ productive emotional processing of primary adaptive emotions. In contrast, interpretations, reassurances, and therapists’ focus on adolescents’ rejecting anger toward their parents were all followed by the discontinuation of adolescents’ emotional processing that had already begun. Finally, therapists’ general encouragement of affect and focus on adolescents’ unmet attachment/identity needs were associated with both the initiation of adolescents’ productive emotional processing, and with the discontinuation of such processing once it had already begun. Theoretical and clinical implications are discussed.     

Art,Empathy and the Divine

Religious art can reconfigure our conception of God’s omniscience. This should be seen in terms of divine understanding, with empathy and love required for God’s understanding of human beings. §I surveys reasons to think that God can empathize with us. §II and §III consider different ways that religious art has attempted to represent such empathetic relations. There are images of Christ’s suffering that elicit empathy in the viewer, and there are depictions of God’s empathetic understanding of humanity. §IV and §V consider the epistemic roles of art and how religious art can reconfigure how we think of God’s omniscience.     

“养中”与“格物”:蔡汝楠对王、湛之学的融通

甘泉学派是中晚明与阳明心学分庭抗礼的存在。两家虽然学术宗旨相异,但并非泾渭分明。不论阳明后学还是甘泉后学中,一直有主张融通的声音。本文以甘泉后学中以往学界缺乏研究的蔡汝楠为例,通过对其“养中”与“格物”观念的分析,探讨其对于王、湛两家之学的融通。在蔡汝楠看来,其“中”与“养中”的观念可以消解“良知”与“天理”之间的紧张,使得本体的主观性与客观性得到统一;其“格物”观则可以将“致良知”和“随处体认天理”统一起来,避免双方之间的彼此攻讦。从本文的分析可以看到,蔡汝楠的“养中”和“格物”,正是颇能体现其自觉融通王、湛两家思想的观念。     

Helping behaviour among people who use drugs: Altruism and mutual aid in a harm reduction program

People who use drugs, and particularly people experiencing addiction, are rarely afforded the opportunity to have their voices heard when it comes to drug treatment or drug policy or even when attempting to define themselves and their life experiences. Of course, there is much more to a person than one area of their behaviour. The current study seeks to capture and understand the lived experiences of people who use drugs, with a focus on their relationships and helping behaviour. We interviewed 32 participants in a harm reduction program seeking to provide understanding beyond stigmatizing and criminalizing drug narratives, by exploring their motivation and context for helping behaviours. Grounded theory methodology was used to understand the patterns of helping behaviour, along with the contexts in which help is or is not given. We particularly focus on participants' distribution of syringes and carrying medicine to reverse overdose (naloxone). Participants shared stories of altruism and mutual aid, along with barriers and disincentives to helping others. We situate these behaviours within contrasting environments of a free harm reduction program and the competitive market system of the U.S. society. Implications for practice and public policy are discussed.     

Guess Who Buys Cheap? The Effect of Consumers’ Goal Orientation on Product Preference

The current research examines how goal orientation affects consumer preference among products with different prices. We argue that a less expensive product may have not only lower perceived quality but also greater perceived quality variability. This greater perceived variability provides the opportunity for optimistic, promotion‐oriented consumers to overestimate the quality of the less expensive product. This effect is weaker, however, for a more expensive product that consumers perceive to have less quality variability and which thus provides less room for quality overestimation. As a result, we hypothesize that promotion‐oriented consumers, as compared to prevention‐oriented consumers, will demonstrate a stronger preference for a less expensive product. In a field study and two laboratory experiments, we obtain empirical support both for the hypothesized effect of consumers’ goal orientation on their product preference and for its underlying process. We conclude with a discussion of the theoretical and practical implications of our results.     

Symbolic Sequence Effects on Consumers’ Judgments of Truth for Brand Claims

We introduce symbolic sequence effects—the consequences of whether the sequence of the initial letters of a pair of words (e.g., a word representing a putative cause and another word representing a putative effect) conforms to the structure of symbolic sequences that are stored in the mind as overlearned natural language traces (“natural sequence”). We synthesize insights from psychophysics as well as numerical and natural language symbolic representations to demonstrate that consumers are able to unconsciously perceive the mere sequence of symbols contained in a brand claim, and that this sequence information influences judgments of truth. Across three experiments, we showed that when a brand claim is structured in a way that is consistent with the natural sequence of symbols (“A causes B” rather than “B causes A”), people experience feelings of sequential fluency, which in turn influences judgments of truth. This occurs despite the inability of participants to attribute the true source of the feelings. Our results suggest that carefully designed brand claims are likely to benefit from this natural sequencing. These findings provide important contributions to the literatures on processing fluency, branding, and advertising. These findings also have sobering societal implications and warn that fake news might be more persuasive if the perpetrators understand symbolic sequencing techniques.     

Young children are more likely to cheat after overhearing that a classmate is smart

Research on moral socialization has largely focused on the role of direct communication and has almost completely ignored a potentially rich source of social influence: evaluative comments that children overhear. We examined for the first time whether overheard comments can shape children's moral behavior. Three‐ and 5‐year‐old children (N = 200) participated in a guessing game in which they were instructed not to cheat by peeking. We randomly assigned children to a condition in which they overheard an experimenter tell another adult that a classmate who was no longer present is smart, or to a control condition in which the overheard conversation consisted of non‐social information. We found that 5‐year‐olds, but not 3‐year‐olds, cheated significantly more often if they overheard the classmate praised for being smart. These findings show that the effects of ability praise can spread far beyond the intended recipient to influence the behavior of children who are mere observers, and they suggest that overheard evaluative comments can be an important force in shaping moral development.     

Consumer preference for bio‐based batteries

Growing concern about the degradation of the environment and public health has called into question the use of conventional household batteries that are consumed and then typically discarded. Because most conventional batteries are not recycled, they end up in landfills where they decompose, potentially leaching harmful chemicals into the surrounding soil. Bio‐based batteries, which are made from agricultural by‐products, have been designed to help meet the need for household batteries while using sustainable, safe technology. This research examines the links between consumer willingness‐to‐pay (WTP) for bio‐based batteries and consumer characteristics and preferences for certain product attributes and environmentally‐friendly practices. We designed a nationwide survey and analyzed the survey data using the dichotomous‐choice contingent valuation method. The results show an increase in the estimated WTP in the Midwest and South in response to an information treatment about bio‐based batteries. Overall, U.S. consumers concerned about green production and recycling practices are willing to pay a premium for bio‐based batteries. Our results provide essential information for quantitatively assessing the potential market impact of bio‐based batteries, for developing effective management and marketing strategies to reach various consumer groups, and for efficiently establishing sustainable policies and regulations.