微创手术治疗肺癌面临问题的思考

作为一种新兴技术,微创外科手术治疗肺癌备受争议.运用唯物辩证法的基本原理,分析这种技术产生的背景、临床应用价值及发展前景,并与传统手术方法作了客观辨证的比较.认为微创外科治疗肺癌,在临床应用有其积极意义,值得肯定.     

特殊人群艾滋病行为干预的思考

艾滋病直接危害人类的健康,也对社会、政治、经济及人文伦理道德产生重大的负面影响。对艾滋病病人犯罪的监管问题,公安干警的职业暴露问题,都是目前司法实践中遇到的新课题。加强艾滋病患者违法监管,对特殊群体进行行为干预,是司法结构急待解决问题。     

活体肝移植应用及其伦理学思考

目前,肝移植已成为治疗终末期肝病的有效手段。活体肝移植术部分解决了供肝短缺的问题,10多年来发展迅速,并取得了良好的疗效。但开展这一技术时务必需要遵循知知情自愿原则和利益和风险并存等原则,注意活供体肝移植在伦理学方面尚未解决的问题。     

正确对待胸腔镜在肿瘤手术中的应用

以胸腔镜为代表的微创胸外科迅速发展并取得了良好的临床效果。胸腔镜手术治疗肺癌和食管癌存在较大争议,全盘否定或盲目应用都会影响胸外科的发展。胸腔镜肺癌、食管癌切除术都有其适应证,对医生提出了更高的技术要求。     

乳腺癌保乳术与根治术的比较

为了比较分析保乳术和根治术的治疗成本和对乳腺癌患者预后的影响,从2002年1月~2005年6月湘雅医院乳腺科的乳腺癌资料库中,随机抽取64例I~II期乳腺癌分为保乳治疗组(A组,32例)和根治术组(B组,32例),并随访。结果显示,A、B两组全部药品费用分别平均为32474.11±16126.00元、35107.30±19352.71元,总费用平均为53959.64±22033.28元、53382.10±24042.87元。两组药品费和总费用均无统计学差异(P=0.556、0.921)。中位随访时间30个月,两组病例均无局部复发。A、B组远处转移率分别为6.25%、9.38%,两组无明显差异(P=0.641);Kaplan-Meier生存分析表明A、B组生存率分别为96.88%、93.75%,两组无显著性差异(P=0.4566)。保乳术患者对残乳的满意率为90.61%,认为保留了乳房后其对家庭和社会生活仍充满自信的分别占75%和87.5%;相反,根治术者仅占28.13%和40.63%;A、B两组有显著性差异(P=0.000、0.000)。由此得出结论,保乳术和根治/改良根治术两种治疗方法对I~II期乳腺癌患者的预后无差异,成本亦无明显区别,而保乳术明显提高了患者的家庭、社会生活质量。     

接受不同术式的直肠癌患者的心理评估比较

对在吉林大学第一医院接受186例直肠癌手术患者进行术前及术后的心理评估。术前第一天和术后第七天分别用汉密顿抑郁量表(HRSD)对病人进行心理评估,接受腹会阴联合根治术(Miles手术)的患者术前有明显抑郁情绪,而术后无缓解,接受经腹直肠癌根治术(Dixon手术)的患者术前有一定抑郁情绪,术后明显缓解。单纯结肠造口患者术前抑郁情绪较重,术后加重。     

气道管理与呼吸机相关性肺炎防治策略

气道管理是机械通气过程中的关键技术,人工气道管理各个环节的处理,关系到机械通气的顺利进行,对呼吸机相关性肺炎(VAP)有不同程度的直接或间接的影响。气道管理的策略应该注重局部和整体的关系,在全身调整的基础上细致地管理气道的各个环节,体现气道管理的艺术。本文结合最新的临床研究证据阐明气道管理与VAP防治的策略。     

The role of production abilities in the perception of consonant category in infants

The influence of motor knowledge on speech perception is well established, but the functional role of the motor system is still poorly understood. The present study explores the hypothesis that speech production abilities may help infants discover phonetic categories in the speech stream, in spite of coarticulation effects. To this aim, we examined the influence of babbling abilities on consonant categorization in 6‐ and 9‐month‐old infants. Using an intersensory matching procedure, we investigated the infants’ capacity to associate auditory information about a consonant in various vowel contexts with visual information about the same consonant, and to map auditory and visual information onto a common phoneme representation. Moreover, a parental questionnaire evaluated the infants’ consonantal repertoire. In a first experiment using /b/–/d/ consonants, we found that infants who displayed babbling abilities and produced the /b/ and/or the /d/ consonants in repetitive sequences were able to correctly perform intersensory matching, while non‐babblers were not. In a second experiment using the /v/–/z/ pair, which is as visually contrasted as the /b/–/d/ pair but which is usually not produced at the tested ages, no significant matching was observed, for any group of infants, babbling or not. These results demonstrate, for the first time, that the emergence of babbling could play a role in the extraction of vowel‐independent representations for consonant place of articulation. They have important implications for speech perception theories, as they highlight the role of sensorimotor interactions in the development of phoneme representations during the first year of life.     

The influence of rule availability and item similarity on metacognitive monitoring during categorisation

In four experiments, we examined the sources of metacognitive judgments during the categorisation of new items after the learning of old items was completed. In the rule condition, the categorisation rule was explicitly given to the participants during learning, while in the no-rule condition participants relied on feedback to infer category membership. In the transfer phase, two types of novel items were used: good and bad transfer items. Transfer items also differed in the level of similarity to their training pairs. In the rule condition, all types of transfer items were classified with high accuracy and confidence. In the no-rule condition, a dissociation between accuracy and confidence was revealed. Good transfer items were classified more accurately than bad transfer items, whereas similar items were classified with higher confidence than dissimilar items. The obtained results suggest the utilisation of two potential cues for metacognitive judgments: declarative knowledge if the correct rule is explicitly available, and item similarity if it is difficult to infer the correct rule from feedback.