Learning in honey bees with brain lesions: how partial mushroom-body ablations affect sucrose responsiveness and tactile antennal learning

Honey bees are ideal organisms for studying associative learning, because they can rapidly learn different sensory cues, even under laboratory conditions. Classical olfactory learning experiments have shown that the mushroom bodies (MBs), a prominent neuropil of the central nervous system of the bee, are involved in olfactory learning and memory formation. We tested whether the MBs are also involved in tactile antennal learning. As in olfactory learning, bees use the antennae during tactile learning to sense tactile cues. We produced specific MB ablations by applying the mitotic blocker hydroxyurea (HU). In Drosophila, HU-induced brain lesions of the MBs strongly impaired olfactory memory formation. As treatment with HU might also interfere with the processing of the reward stimulus, sucrose, we measured the responsiveness to sucrose stimuli in these bees. Treatment with HU led to partial ablations of the median MB sub-units on one or both sides of the brain. We analysed side-specific effects in double-blind tests, testing sucrose responsiveness separately for each antenna, and conditioning first one antenna and then the other in a reversal learning assay. HU-treated bees without detectable ablations were less responsive to sucrose and had a poorer learning performance than untreated controls. Partial MB ablation did not additionally affect responsiveness to sucrose or tactile antennal learning. Interestingly, bees with bilateral MB ablations did not differ from untreated controls in their learning performance during the first learning phase. During reversal learning, acquisition in these bees was significantly lower than that in untreated controls. It is concluded that HU treatment affects sucrose responsiveness and tactile learning even without detectable ablation of neuropils. The effects of MB ablations on tactile learning are not side-specific and not correlated with the volume of the ablated neuropil. Accepted after revision: 15 January 2001 ❚ Electronic Publication     

Autogenic training within the therapeutic scope of schizophrenic patients]

The author calls the reader's attention to the rather strange fact that autogenic training, in spite of worldwide recognition and extensive uses of the method in various disciplines of medicine and spheres of live, has not so far been finding wide application in the medical specialty dealing with mental disorders. After discussing some possible causes of this situation and commenting on first signs of a necessary change in attitude toward autogenic training, he reports his own experience in the treatment of schizophrenic patients with this psychotherapeutic method, emphasizing the need for including psychotherapy in a complex concept of the treatment of psychoses.     

Dynamics of 1:2 Coordination: Sources of Symmetry Breaking

Three asymmetries in the dynamics of 1:2 interlimb coordination were examined: the asymmetry in uncoupled frequencies, the asymmetry in coupled frequencies, and the left-right functional asymmetry of the body. In a bimanual 1:2 task, participants (N = 8) oscillated hand-held pendulums whose uncoupled frequencies were adjusted so that the first kind of asymmetry could be manipulated. For any given pendulum pair, the pendulum assuming the faster motion in the 1:2 coordination was oscillated in the right and the left hands. By assigning combinations of uncoupled eigenfrequencies and coupled task-specified frequencies across hands, the authors studied the interaction of all 3 asymmetries. The results confirm the appropriateness of generalized relative phase as a collective variable for 1:2 coordination. Additionally, they suggest that the generalized form of the detuning parameter represents the first asymmetry and that the coupling function expresses the second asymmetry. In 1:2 coordination, the body's functional asymmetry plays a limited role.     

Dynamics of 1:2 Coordination: Generalizing Relative Phase to n:m Rhythms

Interlimb rhythmic movements can be modeled as coupled oscillators, with stable performance characterized by the relative phase between the limbs. In the present study, that modeling strategy, verified previously for 1:1 coordination, was generalized to 1:2 coordination with a view to n:m coordination. The generalized model predicted interactions between coordination (specifically, 1:1 vs. 1:2) and the frequency asymmetry between the limbs determining mean relative phase and its variability. The predicted interactions were evaluated with bimanual 1:2 and 1:1 rhythmic tasks in which participants (N = 8) oscillated hand-held pendulums whose uncoupled frequencies could be adjusted so that different interlimb asymmetries were produced. The authors needed new analytic procedures to verify stable 1:2 coordination and to resolve stochastic and deterministic sources of variability in the component oscillations. The major expectations from the generalized model were confirmed, and the implications of additional but unpredicted findings for the modeling of multifrequency behavior are discussed.     

The (Holy and Great) Council of the Orthodox Churches: An Ecumenical Perspective

From 19 to 26 June 2016, the first Pan‐Orthodox Council for more than a thousand years took place in Crete, although the Orthodox churches of Russia, Georgia, Bulgaria, and Antioch, for various reasons, did not participate. This article offers an assessment, from an ecumenical perspective, of the preparation and results of the council, and especially the document agreed in Crete concerning the “Relations of the Orthodox Church with the Rest of the Christian World.”     

A rating measure of ADHD-related neuropsychological impairment in children and adolescents: Data from the Cognition and Motivation in Everyday Life (CAMEL) Scale from population and clinical samples

A new parent-completed questionnaire, the Cognition and Motivation in Everyday Life (CAMEL) scale, was developed to provide a comprehensive assessment of neuropsychological impairment in children related to attention-deficit/hyperactivity disorder (ADHD) across diverse cognitive, motivational and energetic domains. Its psychometric properties were investigated. A total of 60 items were generated to cover a wide range of putative ADHD-related neuropsychological processes. A clinical (n = 142) and community (n = 810) sample of parents with children between 6 and 16 years of age completed the questionnaire. Data on ADHD symptoms were also collected with a commonly-used, validated parent rating scale to explore the associations between CAMEL scores and dimensional measures of child ADHD and conduct problems. Factor analysis identified six factors which we labeled (i) Cognition, (ii) Self-Direction and Organization, (iii) Effort Engagement, (iv) Arousal Regulation, (v) Motivational Responsiveness, and (vi) Cautiousness. Self-Direction and Organization and Arousal Regulation were the strongest predictors for ADHD symptomatology. Self-Direction and Organization was strongly associated with inattention and Arousal Regulation with hyperactivity-impulsivity symptoms. Parents distinguished between broad neuropsychological domains in reliable and plausible ways, making distinctions between key aspects of functioning. However, the boundaries between these domains did not map directly onto the distinctions drawn within traditional models of ADHD deficits. Further research is required to examine the predictive validity and cost-effectiveness of the CAMEL scale compared to direct objective testing using laboratory measures in predicting prognosis and treatment outcome.     

Decomposition of variability in the execution of goal-oriented tasks: three components of skill improvement

A central ability of the motor system is to achieve goals with great reliability, although never with zero variability. It is argued that variability is reduced with practice by 3 separate means: reduction of stochastic noise (N), exploitation of task tolerance (T), and covariation (C) between central variables. A method is presented that decomposes variability into these components in relation to task space that is defined by the execution variables. Successful variable combinations form the solution manifold. In a virtual skittles task, it is demonstrated that participants' improvement over repetitions, indicated by increasing accuracy, is accounted for by N, T, and, to a lesser degree, C. The relative contribution of these components changes over the course of practice and task variations.     

Regulatory fit at work: gravitational effects and associations with employee well-being

ABSTRACT

Using a task approach, this study examined the extent to which employee regulatory focus would “gravitate” employees towards promotion- versus prevention-oriented tasks within their jobs, and whether a subsequent regulatory fit/misfit would be associated with their well-being (i.e., mental health and job satisfaction). In a pre-study among 37 employees, we determined the regulatory focus of work tasks from the Netherlands Skill Survey, which are relevant to the general working population, resulting in a selection of 7 promotion and 11 prevention tasks. For our main study, we used the Dutch Longitudinal Internet Studies for the Social Sciences (LISS) panel and collected data from 1,606 respondents. In 2011, we collected respondents’ regulatory focus and in 2012, we collected their work tasks and well-being. Promotion-oriented employees considered both promotion and prevention tasks to be highly relevant in their jobs, and this relevance was associated with their mental health. Prevention-oriented employees, however, did not respond to the relevance of promotion or prevention tasks and generally reported lower well-being, irrespective of the regulatory focus of their tasks. We tentatively conclude that promotion focus gravitates employees towards job with a richer task content, containing both promotion and prevention tasks.