The "anxiety state" and its relation with rat models of memory and habituation.

Rats selected as "anxious", "nonanxious," or normal according to their behavior in an elevated plus maze were submitted to memory tasks and the densities of central benzodiazepine receptors in the amygdala and the hippocampus were studied. Anxious rats exibited better retention scores in the inhibitory avoidance task while nonanxious rats exibited worse retention scores in inhibitory and two-way active avoidance tasks compared to normal rats. No significant differences were detected in the retention scores for habituation to an open field. Nonanxious rats presented a lower benzodiazepine receptor density in the hippocampus but not in the amygdala compared to the other groups. These data suggest that the benzodiazepine receptors are involved in the effect of "anxiety" or emotional states on memory storage processes.     

Processing level and recognition: A search method for inducing alternative encodings of unrelated words

Twenty-four subjects viewed cards containing four words. In synonym orienting, half of the cards contained a synonym pair and half did not; in homophone orienting, half of the displays contained a homophone pair. The remaining two words in each display were used to index retention. During presentation of displays, subjects responded “yes” or “no” to indicate the presence or absence of a matching pair. Following presentation, a recognition test was administered. Half the items were tested early and half were tested late; within each test order, half the items appeared with context cues during testing and half appeared without. Results showed superior recognition (1) following semantic orienting, (2) for items tested early, (3) for items tested with context, and (4) for nonmatch displays requiring exhaustive item comparison. An Orienting by Test Cuing interaction showed that the presence of test cues improved recognition for homophone orienting items only. The interaction may have resulted from the lack of cuetarget associations and the reinstatement of the phonemic orienting set during the test.     

Amnesia by post-training infusion of glutamate receptor antagonists into the amygdala, hippocampus, and entorhinal cortex.

The blockers of glutamate receptors, aminophosphonovaleric acid (AP5) (5.0 micrograms) and cyano-nitroquinoxaline-dione (CNQX) (0.5 microgram), were infused bilaterally into the amygdala, dorsal hippocampus, or entorhinal cortex of rats through indwelling cannulae 0, 90, 180, or 360 min after step-down inhibitory avoidance training. Animals were tested for retention 24 h after training. In the amygdala or hippocampus, AP5 was amnestic when given 0 min after training and CNQX was amnestic when given 0, 90, or 180 min after training. In the entorhinal cortex, AP5 was amnestic when given 90 or 180 min after training and CNQX had no effect. The results suggest that a phenomenon sensitive first to AP5 and then to CNQX in the amygdala and hippocampus, probably long-term potentiation (LTP), is crucial to post-training memory processing. LTP in these two structures could underlie their role in memory consolidation and could explain the late involvement of the entorhinal cortex in post-training memory processing.     

Computerized procedure for analyzing hand kinematics with a peg-moving task (Sarah-Pegworks)

This article describes Sarah-Pegworks, a computerized procedure for analyzing hand kinematics based on the peg-moving task. The procedure, developed in Visual Basic 6 programming language, includes (1) processing raw data from an infrared motion-tracking system, (2) identifying movement components, and (3) analyzing and presenting hand kinematic information in numerical and graphic outputs. Fifty-five normal adults set the parameters relative to filtering and movement identification. A case was presented to illustrate the clinical value of this procedure.     

Memory for an imagined pathway and strategy effects in sighted and in totally congenitally blind individuals

The literature reports mixed results on the imagery abilities of the blind, at times showing a difference between sighted and blind individuals and at other times similarities. However, the possibility that the results are due to different strategies spontaneously used in performing the imagery tasks has never been systematically studied. A large group of 30 totally congenitally blind (TCB) individuals and a group of 30 sighted individuals matched for gender age and schooling were presented with a mental pathway task on a complex two-dimensional (5 × 5) matrix. After administering the task, participants were interviewed in order to establish the strategy they used. Results showed that both sighted and TCB may use a spatial mental imagery, a verbal or a mixed strategy in carrying out the task. Differences between the groups emerged only when last location and then entire pathway had to be remembered rather than just the last position, and were clearly affected by the type of strategy. Specifically, TCB performed more poorly than the sighted individuals when they used a spatial mental imagery strategy, whereas the two groups had a similar performance with a verbal strategy.     

某院3年医院感染患者细菌分离及耐药性分析

应用WHONET5．3软件对2005年1月至2007年12月检出的1749株病原菌种类、分布及其耐药性进行统计分析。结果发现院内感染病原菌以条件致病菌为主,革兰阴性菌检出率61．8％,革兰阳性菌的检出率33％,真菌检出率为5．2％。大肠埃希菌及肺炎克雷伯菌属的ESBLs阳性率分别为34．4％和48．9％,MRSA和MRCNS的检出率分别为40．8％和36．4％。大多数病原菌对抗生素产生多重耐药性。由此可见,由于临床抗生素的广泛使用,病原菌不断变迁且其耐药性逐渐上升,应加强耐药性监测及合理使用抗生素,以有效控制细菌感染和耐药性播散。     

预测加工：走出两代认知科学的历史僵局

表征-计算观与具身行动观对认知的本质几乎做了截然相反的强调。近年来,预测加工理论的发展为统一两代认知科学提供了契机。预测加工是层级预测加工与主动预测加工这两大理论部件的合称,前一部件主要继承了第一代认知科学中的层级计算加工进路,后一部件则发扬了第二代认知科学中与行动有关的理论,这两大理论部件被视为同一个统一整合理论的两个不同方面。在当代,预测加工被认为有望成为未来认知科学的新范式。     

A counselling service as a growth centre

The Associates programme at the University of East Anglia is designed as an opportunity for self-development and as a testing ground for those who want to explore their own helping abilities. The structure and content of the programme are described; some examples are provided of the range of follow-up activities which have arisen from it; and attention is given to the potential of the programme as a contribution to the development of the institution as a community.